Munc-18 Associates with Syntaxin and Serves as a Negative Regulator of Exocytosis in the Pancreatic β-Cell

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

2000 • 1,397 citations

Gel electrophoresis of proteins: a practical approach

1981 • 1,082 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

2000 • 783 citations

A conformational switch in syntaxin during exocytosis: role of munc18

1999 • 742 citations

Gel electrophoresis: Proteins

1997 • 732 citations

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

1993 • 716 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Gel electrophoresis of proteins: A practical approach

1983 • 506 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Identification of a syntaxin-binding site on N-Type calcium channels

1994 • 429 citations

Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport.

1993 • 406 citations

n-Sec1: a neural-specific syntaxin-bindingprotein.

1994 • 392 citations

GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

1991 • 382 citations

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

1981 • 381 citations

Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

1997 • 369 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

The voltage sensitive Lc-type Ca ²⁺ channel is functionally coupled to the exocytotic machinery

1999 • 280 citations

SNAP family of NSF attachment proteins includes a brain-specific isoform

1993 • 277 citations

Nsec1 Binds a Closed Conformation of Syntaxin1a

2000 • 275 citations

rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin.

1995 • 269 citations

A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin.

1994 • 247 citations

Mutations in the drosophila Rop gene suggest a function in general secretion and synaptic transmission

1994 • 241 citations

Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes

1997 • 213 citations

Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells.

1994 • 199 citations

ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner

1998 • 194 citations

The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport.

1991 • 193 citations

Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues

1995 • 183 citations

The unc‐18 Gene Encodes a Novel Protein Affecting the Kinetics of Acetylcholine Metabolism in the Nematode Caenorhabditis elegans

1992 • 181 citations

A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

1995 • 178 citations

Rop, a drosophila homolog of yeast Sec1 and vertebrate n-Sect/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo

1994 • 173 citations

An immunocytochemical investigation with monoclonal antibodies to somatostatin

1985 • 172 citations

Inhibition of Insulin-induced GLUT4 Translocation by Munc18c through Interaction with Syntaxin4 in 3T3-L1 Adipocytes

1998 • 153 citations

The Sec1 Family: A Novel Family of Proteins Involved in Synaptic Transmission and General Secretion

1996 • 147 citations

Genetic and biochemical analysis of vesicular traffic in yeast

1992 • 138 citations

Syntaxin 1 interacts with the L _D subtype of voltage-gated Ca ²⁺ channels in pancreatic β cells

1999 • 138 citations

The C. elegans unc-18 gene encodes a protein expressed in motor neurons

1993 • 119 citations

Expression and Functional Role of Syntaxin 1/HPC-1 in Pancreatic β Cells

1996 • 112 citations

Inhibition of the Binding of SNAP-23 to Syntaxin 4 by Munc18c

1997 • 92 citations

In chromaffin cells, the mammalian Sec1p homologue is a syntaxin 1A-binding protein associated with chromaffin granules.

1994 • 86 citations

A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells

1995 • 85 citations

SNAREs line up in new environment

1998 • 79 citations

The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype

1993 • 72 citations

A Neuronal Sec1 Homolog Regulates Neurotransmitter Release at the Squid Giant Synapse

1998 • 69 citations

A Sec1‐Related Vesicle‐Transport Protein that is Expressed Predominantly in Epithelial Cells

1996 • 63 citations

Role of syntaxin in mouse pancreatic beta cells

1995 • 63 citations

Perifusion of a Clonal Cell Line of Simian Virus 40-Transformed Beta Cells: Insulin Secretory Dynamics in Response to Glucose, 3-Isobutyl-1-Methylxanthine, and Potassium

1985 • 49 citations

A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.

1996 • 49 citations

Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca2+- but not for guanosine 5′-[γ-thio]triphosphate-induced secretion

1996 • 38 citations

A Murine Neural-Specific Homolog Corrects Cholinergic Defects inCaenorhabditis elegans unc-18Mutants

1996 • 38 citations

nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules

1999 • 27 citations

Cloning of a Putative Vesicle Transport-related Protein, RA410, from Cultured Rat Astrocytes and Its Expression in Ischemic Rat Brain

1997 • 23 citations

Genetic dissection of the molecular mechanisms of transmitter vesicle release during synaptic transmission

1995 • 22 citations

EJCB-Lecture. SNAREs and the organization of the secretory pathway.

1997 • 14 citations