GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles

1985 • 1,425 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

First visualization of glutamate and GABA in neurones by immunocytochemistry

1983 • 872 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

1985 • 716 citations

Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.

1986 • 671 citations

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

1990 • 618 citations

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

1981 • 560 citations

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.

1983 • 535 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

1980 • 496 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

1982 • 476 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

1989 • 451 citations

Production of a specific antiserum to rat brain glutamic acid decar☐ylase by injection of an antigen-antibody complex

1981 • 424 citations

Experimental observations on the development of polarity by hippocampal neurons in culture.

1989 • 419 citations

Chemical Anatomy of the Brain

1984 • 411 citations

Immunocytochemical localization of glutamate decar☐ylase in rat cerebellum with a new antiserum

1981 • 407 citations

Secretogranins I and II: two tyrosine-sulfated secretory proteins common to a variety of cells secreting peptides by the regulated pathway.

1985 • 384 citations

An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture. I. Cells which develop without intercellular contacts

1984 • 358 citations

Depolarization Without Calcium Can Release γ-Aminobutyric Acid from a Retinal Neuron

1987 • 352 citations

Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase

1988 • 334 citations

Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate

1989 • 297 citations

γ‐Aminobutyric Acid Outside the Mammalian Brain

1990 • 256 citations

High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human Insulinoma

1976 • 235 citations

The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.

1987 • 229 citations

Immunohistochemical Localization of Glutamate Decarboxylase in Rat Cerebellum

1974 • 219 citations

The diffuse neuroendocrine system and the apud concept: related "endocrine" peptides in brain, intestine, pituitary, placenta, and anuran cutaneous glands.

1977 • 215 citations

GABAergic mechanisms in the mammalian periphery

1987 • 197 citations

On the origin of pancreatic endocrine cells

1988 • 195 citations

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein

1987 • 187 citations

Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12.

1990 • 187 citations

Immunocytochemical localization of GABA in the cochlear nucleus of the guinea pig

1986 • 179 citations

Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure.

1988 • 174 citations

Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells.

1989 • 157 citations

The fine structural localization of glutamate decarboxylase in developing axonal processes and presynaptic terminals of rodent cerebellum

1975 • 139 citations

Cell lineage analysis of pancreatic islet cell development: Glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct

1987 • 136 citations

Proglucagon Processing Similar to Normal Islets in Pancreatic α-Like Cell Line Derived From Transgenic Mouse Tumor

1990 • 134 citations

Successful Allotransplantation of Mouse Pancreatic Islets to Nonimmunosuppressed Recipients

1980 • 124 citations

Textbook of Endocrinology

1974 • 117 citations

Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells.

1982 • 117 citations

Microvesicles of the neurohypophysis are biochemically related to small synaptic vesicles of presynaptic nerve terminals.

1989 • 105 citations

Immunohistochemical Studies of the GABA System in the Pancreas

1983 • 103 citations

The major tyrosine-sulfated protein of the bovine anterior pituitary is a secretory protein present in gonadotrophs, thyrotrophs, mammotrophs, and corticotrophs.

1985 • 101 citations

Two integral membrane proteins located in the cis-middle and trans-part of the Golgi system acquire sialylated N-linked carbohydrates and display different turnovers and sensitivity to cAMP-dependent phosphorylation.

1987 • 100 citations

P29: a novel tyrosine-phosphorylated membrane protein present in small clear vesicles of neurons and endocrine cells.

1990 • 99 citations

Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse

1990 • 88 citations

Sorting during transport to the surface of PC12 cells: divergence of synaptic vesicle and secretory granule proteins.

1990 • 84 citations

Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor

1982 • 82 citations

Characterization of a cDNA coding for rat glutamic acid decarboxylase

1990 • 80 citations

Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA

1990 • 77 citations

Fractionation of synaptophysin‐containing vesicles from rat brain and cultured PC12 pheochromocytoma cells

1988 • 73 citations

Markers for neural and endocrine cells

1991 • 68 citations

Regulated Secretory Pathways of Neurons and Their Relation to the Regulated Secretory Pathway of Endocrine Cells

1987 • 62 citations

Evidence for Two Distinct Forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study

1987 • 62 citations

Microdetermination of Free Amino Acids in Pancreatic Islets Isolated from Obese‐Hyperglycemic Mice

1972 • 57 citations

Accumulation of adrenocorticotropin secretory granules in the midbody of telophase AtT20 cells: evidence that secretory granules move anterogradely along microtubules

1987 • 55 citations

Morphological and biochemical evidence showing neuronal properties in AtT-20 cells and their growth cones.

1989 • 49 citations

Effect of Muscimol on Glucose-stimulated Somatostatin and Insulin Release from the Isolated, Perfused Rat Pancreas

1981 • 49 citations

Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man

1982 • 46 citations

Expression of cell type-specific markers during pancreatic development in the mouse: implications for pancreatic cell lineages

1987 • 37 citations

Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

1990 • 36 citations

Ultrastructural localization of gamma amino butyric acid immunoreactivity in B cells of the rat pancreas

1987 • 32 citations

A Possible Role for λ-Aminobutyric Acid in the Control of the Endocrine Pancreas*

1982 • 32 citations

Localization of human growth hormone to a sub-set of cytoplasmic vesicles in transfected PC12 cells

1990 • 31 citations

64,000-Mr Autoantigen in Type I Diabetes: Evidence Against Its Surface Location on Human Islets

1987 • 30 citations

Altered Differentiated Cell Surface Properties of Transformed (RINm5F) Compared with Native Adult Rat Pancreatic B Cells*

1988 • 14 citations