Genetic dissection of the molecular mechanisms of transmitter vesicle release during synaptic transmission

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

1995 • 921 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

The syntaxin family of vesicular transport receptors

1993 • 656 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction

1965 • 600 citations

VAMP-1: a synaptic vesicle-associated integral membrane protein.

1988 • 574 citations

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

1981 • 560 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae

1979 • 518 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release

1993 • 457 citations

Identification of a syntaxin-binding site on N-Type calcium channels

1994 • 429 citations

Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport.

1993 • 406 citations

Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

1993 • 386 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Paralysis and Early Death in Cysteine String Protein Mutants of Drosophila

1994 • 367 citations

Domain structure of synaptotagmin (p65)

1991 • 350 citations

Storage and release of neurotransmitters

1993 • 324 citations

Clostridial neurotoxins: new tools for dissecting exocytosis

1994 • 323 citations

Genetic and electrophysiological studies of drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission

1995 • 321 citations

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

1994 • 286 citations

HPC-1 is associated with synaptotagmin and omega-conotoxin receptor.

1992 • 275 citations

A synaptic vesicle membrane protein is conserved from mammals to Drosophila

1989 • 272 citations

Expression of Synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse

1993 • 259 citations

A post-docking role for synaptobrevin in synaptic vesicle fusion

1994 • 255 citations

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

1993 • 253 citations

The effect on synaptic physiology of synaptotagmin mutations in drosophila

1994 • 253 citations

Synaptic transmission persists in synaptotagmin mutants of Drosophila

1993 • 249 citations

A MOLECULAR DESCRIPTION OF SYNAPTIC VESICLE MEMBRANE TRAFFICKING

1994 • 248 citations

Mutations in the drosophila Rop gene suggest a function in general secretion and synaptic transmission

1994 • 241 citations

Development of the embryonic neuromuscular synapse of Drosophila melanogaster

1993 • 240 citations

A Cysteine-String Protein is Expressed in Retina and Brain ofDrosophila

1990 • 212 citations

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

1994 • 206 citations

Functional properties of multiple synaptotagmins in brain

1994 • 195 citations

The unc‐18 Gene Encodes a Novel Protein Affecting the Kinetics of Acetylcholine Metabolism in the Nematode Caenorhabditis elegans

1992 • 181 citations

Cysteine String Proteins: a Potential Link Between Synaptic Vesicles and Presynaptic Ca ²⁺ Channels

1994 • 180 citations

Rop, a drosophila homolog of yeast Sec1 and vertebrate n-Sect/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo

1994 • 173 citations

Interaction of synaptotagmin with the cytoplasmic domains of neurexins

1993 • 170 citations

Presynaptic dysfunction in drosophila csp mutants

1994 • 166 citations

Identification and characterization of Drosophila genes for synaptic vesicle proteins

1993 • 149 citations

Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel

1992 • 132 citations

The C. elegans unc-18 gene encodes a protein expressed in motor neurons

1993 • 119 citations

In chromaffin cells, the mammalian Sec1p homologue is a syntaxin 1A-binding protein associated with chromaffin granules.

1994 • 86 citations

From growth cone to synapse: the life history of the RP3 motor neuron

1993 • 47 citations

Synaptogenesis in Drosophila: Coupling genetics and electrophysiology

1994 • 22 citations