Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

1984 • 579 citations

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

1990 • 561 citations

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question

2001 • 519 citations

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO

1974 • 488 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice

1999 • 303 citations

The Homograft Reaction

1957 • 290 citations

Thyroid Allograft Immunogenicity Is Reduced After a Period in Organ Culture

1975 • 222 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

2000 • 180 citations

Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection

2001 • 172 citations

Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.

1985 • 160 citations

Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.

1994 • 156 citations

CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses

1999 • 153 citations

CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

2000 • 153 citations

Significant Frequencies of T Cells With Indirect Anti-Donor Specificity in Heart Graft Recipients With Chronic Rejection

2000 • 140 citations

Are primary alloresponses truly primary?

1990 • 132 citations

Assessment of the Contribution That Direct Allorecognition Makes to the Progression of Chronic Cardiac Transplant Rejection in Humans

1998 • 132 citations

THE ROLE OF LYMPHOCYTES IN THE SENSITIZATION OF RATS TO RENAL HOMOGRAFTS

1965 • 124 citations

DONOR ANTIGEN IS NECESSARY FOR THE PREVENTION OF CHRONIC REJECTION IN CTLA4IG-TREATED MURINE CARDIAC ALLOGRAFT RECIPIENTS1,2

1997 • 114 citations

Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells

2000 • 114 citations

T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.

1984 • 108 citations

Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype

2000 • 101 citations

Generation of cytotoxic T lymphocytes in vitro. V. Response of normal and immune spleen cells to subcellular alloantigens.

1975 • 84 citations

Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen-presenting cells in vivo.

1992 • 70 citations

IMPACT OF CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION ON THE IMMUNOGENIC POTENTIAL OF ISOLATED RAT VASCULAR ENDOTHELIAL CELLS

1987 • 63 citations

Generation of Cytotoxic T Lymphocytes in Vitro

1975 • 55 citations

Endothelial Antigen Presentation: Stimulation of Previously Activated but Not Naı̈ve TCR-Transgenic Mouse T Cells

1998 • 49 citations

Activated Murine Endothelial Cells Have Reduced Immunogenicity for CD8+ T Cells: A Mechanism of Immunoregulation?

2000 • 47 citations

REPLACEMENT OF GRAFT-RESIDENT DONOR-TYPE ANTIGEN PRESENTING CELLS ALTERS THE TEMPO AND PATHOGENESIS OF MURINE CARDIAC ALLOGRAFT REJECTION1

2000 • 44 citations

T cell contact with Ia antigens on nonhemopoietic cells in vivo can lead to immunity rather than tolerance.

1991 • 43 citations

IMMUNOGENICITY OF MHC CLASS I ALLOANTIGENS EXPRESSED ON PARENCHYMAL CELLS IN THE HUMAN KIDNEY

1992 • 41 citations

A simple method for culturing mouse vascular endothelium

2001 • 38 citations

PROLONGATION OF ISLET ALLOGRAFT SURVIVAL

1979 • 37 citations

Cultured epithelium allografts: Langerhans cell and Thy-1+ dendritic epidermal cell depletion effects on allograft rejection.

1993 • 36 citations

PREVENTION OF ALLOANTIBODY FORMATION AFTER SKIN GRAFTING WITHOUT PROLONGATION OF GRAFT SURVIVAL

1988 • 35 citations

CULTURED EPITHELIUM ALLOGRAFTS

1993 • 31 citations

EFFECTS OF BWH-4 ANTI-CD4 MONOCLONAL ANTIBODY ON RAT VASCULARIZED CARDIAC ALLOGRAFTS BEFORE AND AFTER ENGRAFTMENT

1991 • 26 citations

Analysis of cross-reactive antigen-specific T cell clones. Specific recognition of two major histocompatibility complex (MHC) and two non-MHC antigens by a single clone.

1983 • 22 citations

T CELL SUBSET RESPONSES TO ALLOGENEIC ENDOTHELIUM

1993 • 20 citations