Minimally Modified LDL Binds to CD14, Induces Macrophage Spreading via TLR4/MD-2, and Inhibits Phagocytosis of Apoptotic Cells

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Atherosclerosis

2001 • 2,982 citations

LPS induction of gene expression in human monocytes

2001 • 2,276 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Toll-like Receptor 4 Polymorphisms and Atherogenesis

2002 • 1,030 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation.

2002 • 843 citations

Expression of Toll-Like Receptors in Human Atherosclerotic Lesions

2002 • 669 citations

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

2000 • 669 citations

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

2000 • 663 citations

Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL

2001 • 659 citations

Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid–protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins

1999 • 552 citations

Toll-like receptors as adjuvant receptors

2002 • 499 citations

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

1999 • 461 citations

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

2001 • 398 citations

Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

2002 • 363 citations

Mouse Toll-like Receptor 4·MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol

2000 • 355 citations

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

1997 • 346 citations

C(−260)→T Polymorphism in the Promoter of the CD14 Monocyte Receptor Gene as a Risk Factor for Myocardial Infarction

1999 • 337 citations

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

1996 • 326 citations

Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB

2000 • 322 citations

MD-2 Binds to Bacterial Lipopolysaccharide

2001 • 308 citations

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.

1993 • 291 citations

Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation

1996 • 260 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells

2000 • 201 citations

Correlation of Antiphospholipid Antibody Recognition with the Structure of Synthetic Oxidized Phospholipids

2002 • 194 citations

Effect of Immune Deficiency on Lipoproteins and Atherosclerosis in Male Apolipoprotein E–Deficient Mice

2001 • 184 citations

Infectious Agents Are Not Necessary for Murine Atherogenesis

2000 • 178 citations

Endothelial Responses to Oxidized Lipoproteins Determine Genetic Susceptibility to Atherosclerosis in Mice

2000 • 175 citations

Evidence for a Role of Phospholipid Oxidation Products in Atherogenesis

2001 • 174 citations

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

2001 • 160 citations

Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation

2001 • 126 citations

Requirement of Mitogen-Activated Protein Kinases and IκB Phosphorylation for Induction of Proinflammatory Cytokines Synthesis by Macrophages Indicates Functional Similarity of Receptors Triggered by Glycosylphosphatidylinositol Anchors from Parasitic Protozoa and Bacterial Lipopolysaccharide

2001 • 110 citations

Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase

1995 • 107 citations

A Region of Human CD14 Required for Lipopolysaccharide Binding

1995 • 103 citations

Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation

1996 • 97 citations

Convergence of αvβ3Integrin–And Macrophage Colony Stimulating Factor–Mediated Signals on Phospholipase Cγ in Prefusion Osteoclasts

2001 • 96 citations

Phosphatidylinositides Bind to Plasma Membrane CD14 and Can Prevent Monocyte Activation by Bacterial Lipopolysaccharide

1998 • 94 citations

Lipopolysaccharide-Induced Activation of β2-Integrin Function in Macrophages Requires Irak Kinase Activity, p38 Mitogen- Activated Protein Kinase, and the Rap1 GTPase

2001 • 94 citations

CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes

1999 • 83 citations

12/15-Lipoxygenase Translocation Enhances Site-specific Actin Polymerization in Macrophages Phagocytosing Apoptotic Cells

2001 • 74 citations

Fibroblasts That Overexpress 15-Lipoxygenase Generate Bioactive and Minimally Modified LDL

1997 • 71 citations

Circulating monocytes in patients with diabetes mellitus, arterial disease, and increased CD14 expression

2000 • 70 citations

All ApoB-Containing Lipoproteins Induce Monocyte Chemotaxis and Adhesion When Minimally Modified

1999 • 65 citations

Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase.

1995 • 64 citations

Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway

2002 • 42 citations

Soluble CD14 Mediates Efflux of Phospholipids from Cells

2001 • 35 citations

Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-κB

1998 • 31 citations

Identification of a Biochemical Lesion, and Characteristic Response to Lipopolysaccharide (LPS) of a Cultured Macrophage-Like Cell Mutant with Defective LPS-Binding1

1994 • 28 citations