Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction

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1999 • 3,364 citations

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1999 • 2,188 citations

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1999 • 1,905 citations

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Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 • 1,028 citations

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Human Toll-like receptor 4 recognizes host-specific LPS modifications

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Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction

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Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4

2001 • 234 citations

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Monomeric Recombinant MD-2 Binds Toll-like Receptor 4 Tightly and Confers Lipopolysaccharide Responsiveness

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Internalization of Monomeric Lipopolysaccharide Occurs after Transfer Out of Cell Surface Cd14

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The role of disulfide bonds in the assembly and function of MD-2

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Identification of Mouse MD-2 Residues Important for Forming the Cell Surface TLR4-MD-2 Complex Recognized by Anti-TLR4-MD-2 Antibodies, and for Conferring LPS and Taxol Responsiveness on Mouse TLR4 by Alanine-Scanning Mutagenesis

2003 • 73 citations

Identification of LPS-Binding Peptide Fragment of MD-2, a Toll-Receptor Accessory Protein

2002 • 68 citations

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