Lipopolysaccharide-Binding Protein Critically Regulates Lipopolysaccharide-Induced IFN-β Signaling Pathway in Human Monocytes

Innate Immune Recognition

2002 • 8,157 citations

Toll-Like Receptors

2003 • 6,127 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Innate immune sensing and its roots: the story of endotoxin

2003 • 1,316 citations

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

2003 • 1,226 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 • 1,137 citations

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 • 1,028 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

2001 • 693 citations

Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved

2003 • 639 citations

The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

2002 • 481 citations

LPS-binding proteins and receptors

1998 • 480 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

1996 • 475 citations

Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes.

1991 • 427 citations

TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

2003 • 399 citations

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

2003 • 357 citations

Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

1997 • 354 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation

2002 • 279 citations

Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

2001 • 261 citations

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

2001 • 226 citations

A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.

1988 • 224 citations

Dual Role of Lipopolysaccharide (LPS)-Binding Protein in Neutralization of LPS and Enhancement of LPS-Induced Activation of Mononuclear Cells

2001 • 217 citations

Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes.

1992 • 213 citations

Combinations of ERK and p38 MAPK Inhibitors Ablate Tumor Necrosis Factor-α (TNF-α) mRNA Induction

2001 • 174 citations

LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction

2001 • 158 citations

Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.

1993 • 135 citations

Macrophage-Derived Dendritic Cells Have Strong Th1-Polarizing Potential Mediated by β-Chemokines Rather Than IL-12

2000 • 133 citations

Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.

1996 • 128 citations

Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide

1993 • 128 citations

Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14

1996 • 114 citations

Type I interferons and T helper development

2000 • 98 citations

Relative concentrations of endotoxin-binding proteins in body fluids during infection

1994 • 96 citations

Lipopolysaccharide‐Binding Protein Serum Levels in Patients with Severe Sepsis Due to Gram‐Positive and Fungal Infections

2003 • 95 citations

Interpretation of the complexity of innate immune responses by functional genomics

2002 • 92 citations

Lipopolysaccharide Directly Stimulates the Intrapituitary Interleukin-6 Production by Folliculostellate Cells via Specific Receptors and the p38α Mitogen-Activated Protein Kinase/Nuclear Factor-κB Pathway**Supported by a grant from the DFG: Sta 285/7–3.

2000 • 90 citations

Microarray analysis of lipopolysaccharide-treated human neutrophils

2003 • 87 citations

Lipopolysaccharide (LPS)-Binding Protein In Human Serum Determines The Tumor Necrosis Factor Response Of Monocytes To LPS

1994 • 77 citations

Lipopolysaccharide-Binding Protein Is Vectorially Secreted and Transported by Cultured Intestinal Epithelial Cells and Is Present in the Intestinal Mucus of Mice

2000 • 66 citations

Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006.

2003 • 62 citations

Neutrophil adherence induced by lipopolysaccharide in vitro. Role of plasma component interaction with lipopolysaccharide.

1992 • 47 citations

Contribution of CR3 to Nitric Oxide Production from Macrophages Stimulated with High-Dose of LPS

1998 • 45 citations

Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors

2003 • 43 citations

Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein.

1995 • 41 citations

Differential regulation of the expression of transporters associated with antigen processing, TAP1 and TAP2, by cytokines and lipopolysaccharide in primary human macrophages

2002 • 25 citations

The gene expression profile of human umbilical vein endothelial cells stimulated with lipopolysaccharide using cDNA microarray analysis

2003 • 22 citations

Structure and Expression of the Human Small Cytokine B Subfamily Member 11 (SCYB11/formerly SCYB9B, alias I-TAC) Gene Cloned from IFNHuman gamma-Treated Monocytes (THP-1)

1999 • 16 citations

Purification of lipopolysaccharide-binding protein from bovine serum

1996 • 12 citations