Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Transforming growth factor beta

2011 • 1,990 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

1997 • 743 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 • 706 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Expression of connective tissue growth factor in human renal fibrosis

1998 • 545 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Human Connective Tissue Growth Factor Is Expressed in Advanced Atherosclerotic Lesions

1997 • 301 citations

Epithelioid and fibroblastic rat kidney cell clones: Epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation

1978 • 296 citations

Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic Sclerosis

1995 • 278 citations

Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats.

1985 • 277 citations

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

1998 • 242 citations

Respiratory gas tensions and pH in healing wounds

1967 • 234 citations

Basics of Cutaneous Wound Repair

1993 • 214 citations

Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway.

1997 • 194 citations

Transgenic indicator mice for studying activated retinoic acid receptors during development.

1992 • 170 citations

Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta

1989 • 158 citations

Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

1998 • 156 citations

Evaluation of Transforming Growth Factor β and Type I Procollagen Gene Expression in Fibrotic Skin Disease by In Situ Hybridization

1990 • 155 citations

Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.

1991 • 131 citations

Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors

1997 • 129 citations

Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta.

1987 • 126 citations

Regulation of expression of the type I collagen genes

1993 • 121 citations

Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β

1998 • 118 citations

Pentoxifylline Inhibits Normal Human Dermal Fibroblast In Vitro Proliferation, Collagen, Glycosaminoglycan, and Fibronectin Production, and Increases Collagenase Activity

1989 • 116 citations

Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases

1991 • 111 citations

A quantitative assay for collagen synthesis in microwell fibroblast cultures

1979 • 108 citations

Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization.

1992 • 106 citations

Inhibition of TGF‐β‐stimulated CTGF gene expression and anchorage‐independent growth by cAMP identifies a CTGF‐dependent restriction point in the cell cycle

1998 • 103 citations

PGE2 causes a coordinate decrease in the steady state levels of fibronectin and types I and III procollagen mRNAs in normal human dermal fibroblasts

1987 • 100 citations

Differential Regulation of Collagen, Glycosaminoglycan, Fibronectin, and Collagenase Activity Production in Cultured Human Adult Dermal Fibroblasts by Interleukin 1-Alpha and Beta and Tumor Necrosis Factor-Alpha and Beta.

1989 • 94 citations

Wound healing: a comparative study of the histochemical changes in granulation tissue contained in stainless steel wire mesh and polyvinyl sponge cylinders.

1959 • 85 citations

Pentoxifylline, Pentifylline, and Interferons Decrease Type I and III Procollagen mRNA Levels in Dermal Fibroblasts: Evidence for Mediation by Nuclear Factor 1 Down-Regulation

1995 • 85 citations

A Possible Role for Transforming Growth Factor-β in Systemic Sclerosis

1990 • 76 citations

Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells

1997 • 70 citations

Second Messenger Signaling in the Regulation of Collagenase Production by Osteogenic Sarcoma Cells*

1989 • 64 citations

Pentoxifylline Inhibits Certain Constitutive and Tumor Necrosis Factor-α-Induced Activities of Human Normal Dermal Fibroblasts

1992 • 45 citations

Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism

1996 • 38 citations

Opposite and independent actions of cyclic AMP and transforming growth factor β in the regulation of type 1 plasminogen activator inhibitor expression

1992 • 32 citations

Inhibitory effects of transforming growth factor-β on laminin production and growth exhibited by endoderm-like cells derived from embryonal carcinoma cells

1989 • 24 citations

Standardized Nomenclature for Transgenic Animals: Committee on Transgenic Nomenclature Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council

1992 • 9 citations