Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21 activated, AP-1-dependent pathway

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.

1994 • 607 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats

1988 • 413 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Isolation of a pure suspension of rat proximal tubules

1981 • 349 citations

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

1994 • 313 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure.

1988 • 294 citations

Significance of Tubulointerstitial Changes in the Renal Cortex for the Excretory Function and Concentration Ability of the Kidney: A Morphometric Contribution

1987 • 294 citations

Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats

1996 • 293 citations

Pharmacology of competitive inhibitors of HMg-CoA reductase

1995 • 276 citations

Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells

1991 • 259 citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 • 257 citations

Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions.

1994 • 245 citations

HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits.

1993 • 229 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Biochemistry of protein prenylation.

1992 • 216 citations

c-myc as an inducer of polycystic kidney disease in transgenic mice

1991 • 210 citations

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

1995 • 197 citations

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

1996 • 185 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Lovastatin inhibits proliferation of rat mesangial cells.

1993 • 173 citations

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

1996 • 166 citations

Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease.

1987 • 150 citations

Comparative Pharmacokinetics and Pharmacodynamics of Pravastatin and Lovastatin

1990 • 149 citations

Inhibition of cell growth by lovastatin is independent of ras function.

1991 • 130 citations

Lovastatin but not enalapril reduces glomerular injury in Dahl salt-sensitive rats.

1992 • 100 citations

Abnormal extracellular matrix and excessive growth of human adult polycystic kidney disease epithelia

1992 • 99 citations

Effect of lovastatin on the development of polycystic kidney disease in the han:SPRD rat

1995 • 98 citations

Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells

1993 • 97 citations

Insulin-like Growth Factor I, a Unique Calcium-dependent Stimulator of 1,25-Dihydroxyvitamin D3 Production

1995 • 93 citations

Lovastatin, a Cholesterol Biosynthesis Inhibitor, Inhibits the Growth of Human H-ras Oncogene Transformed Cells in Nude Mice

1991 • 92 citations

Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis.

1993 • 90 citations

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys.

1993 • 81 citations

Evolving role of growth factors in the renal response to acute and chronic disease.

1992 • 68 citations

Inhibition of growth factor signaling pathways by lovastatin

1991 • 51 citations

Specific Labeling of Isoprenylated Proteins: Application to Study Inhibitors of the Post-translational Farnesylation and Geranylgeranylation

1995 • 45 citations

Tumor resistance to oxidative stress: Association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation

1995 • 44 citations

Protein kinase C activation has dissimilar effects on sodium-coupled uptakes in renal proximal tubular cells in primary culture

1989 • 43 citations

Lovastatin Inhibits the Stimulation of Mitogen-Activated Protein Kinase by Insulin in HIRcB Fibroblasts

1996 • 41 citations

Pexicrine effects of basement membrane components on paracrine signaling by renal tubular cells

1996 • 41 citations

Effects of a Competitive Inhibitor (Mevinolin) of 3‐Hydroxy‐3‐methylglutaryl Coenzyme A Reductase on Human and Bovine Endothelial Cells, Fibroblasts and Smooth Muscle Cells in Vitro

1989 • 39 citations

Differential sensitivity of normal and H-ras oncogene-transformed ratkidney epithelial cells to okadaic acid-induced apoptosis

1996 • 35 citations

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.

1995 • 26 citations

Hyperplasia precedes increased glomerular filtration rate in rat remnant kidney

1990 • 25 citations

Primary response gene expression in renal hypertrophy and hyperplasia: evidence for different growth initiation processes

1991 • 23 citations

Subtotal but not unilateral nephrectomy induces hyperplasia and protooncogene expression

1995 • 21 citations

Measurement of proliferation in renal biopsy specimens: evidence of subclinical tubular damage in the nephrotic syndrome

1995 • 21 citations

Activation of c-fos expression by transforming Ha-ras in HC11 mouse mammary epithelial cells is PKC-dependent and mediated by the serum response element

1994 • 13 citations

Lovastatin Selectively Inhibits ras Activation of the 12-O-Tetradecanoylphorbol-13-Acetate Response Element in Mammalian Cells

1991 • 10 citations

Serum Factors Induce C-fos Expression and Rapid Cell Proliferation in Adolescent But Not in Infant Rat Proximal Tubule Cells

1991 • 9 citations

Phosphorylation of c-Jun stimulated in primary cultured rat liver parenchymal cells by a coplanar polychlorinated biphenyl

1996 • 8 citations

Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

1991 • 7 citations

Effect of virus-transformation and growth factor stimulation on isoprene biosynthesis in human fibroblasts: a correlation to cell growth.

1995 • 2 citations