Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

Pathologic observations in systemic sclerosis (scleroderma)

1969 • 1,071 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

1992 • 323 citations

Mortality and causes of death in a Swedish series of systemic sclerosis patients

1998 • 251 citations

Scleroderma

1979 • 241 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

1996 • 166 citations

The Molecular Pathology of Autoimmune Diseases

2002 • 163 citations

Functional analysis of human alpha 1(I) procollagen gene promoter. Differential activity in collagen-producing and -nonproducing cells and response to transforming growth factor beta 1.

1994 • 158 citations

p21^WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

1998 • 138 citations

Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation

1996 • 119 citations

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.

1994 • 113 citations

Increased expression of type VI collagen genes in systemic sclerosis

1990 • 97 citations

Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFβ1 stimulation

1992 • 95 citations

Increased type I collagen mRNA levels in cultured scleroderma fibroblasts

1984 • 76 citations

Modulation of human α1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro

1998 • 74 citations

Stabilization of Elastin mRNA by TGF- β : Initial Characterization of Signaling Pathway

1997 • 70 citations

Identification of elements in the promoter region of the ?1(I) procollagen gene involved in its up-regulated expression in systemic sclerosis

1998 • 58 citations

Positive regulation of human α1 (I) collagen promoter activity by transcription factor Sp1

1995 • 56 citations

Transcriptional activation of the α1(1) procollagen gene in systemic sclerosis dermal fibroblasts. Role of intronic sequences

1996 • 54 citations

Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms

1997 • 51 citations

Modulation of basal expression of the human α1(I) procollagen gene (COL1A1) by tandem NF-1/Sp1 promoter elements in normal human dermal fibroblasts

1998 • 32 citations

Arthritis and Allied Conditions

1941 • 29 citations

Signaling Pathway by which TGF-β1 Increases Expression of Latent TGF-β Binding Protein-2 at the Transcriptional Level

1998 • 28 citations

Requirement for Geranylgeranyl Transferase I and Acyl Transferase in the TGF-β-Stimulated Pathway Leading to Elastin mRNA Stabilization

1998 • 25 citations

Quantification and specific detection of collagenous proteins using an enzyme-linked immunosorbent assay and an immunoblotting for cyanogen bromide peptides

1985 • 25 citations

Developmental Changes in Prostacyclin Synthesis Are Conserved in Cultured Pulmonary Endothelium and Vascular Smooth Muscle

1999 • 22 citations

Scleroderma. Modern Medical Monographs.

1967 • 17 citations

Deleted Work

1955 • 0 citations