Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Gene therapy - promises, problems and prospects

1997 • 1,692 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

1997 • 588 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

Gene therapy: adenovirus vectors

1993 • 423 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

1996 • 350 citations

Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma

1993 • 320 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

1997 • 257 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

1993 • 179 citations

Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis

1998 • 157 citations

The Relationship of Angiogenesis to Biological Activity in Human Squamous Cell Carcinomas of the Head and Neck

1994 • 104 citations

Adenoviral gene transfer of nitric oxide synthase: High level expression in human vascular cells

1996 • 92 citations

A functional soluble extracellular region of the platelet-derived growth factor (PDGF) beta-receptor antagonizes PDGF-stimulated responses.

1991 • 89 citations

Specificity of Vascular Endothelial Cell Growth Factor Receptor Ligand Binding Domains

1994 • 83 citations

Induction of Antitumor Immunity by Interleukin-2 Gene-Transduced Mouse Mammary Tumor Cells Versus Transduced Mammary Stromal Fibroblasts

1993 • 66 citations

Adeno-associated virus-mediated gene transfer into rat carotid arteries

1997 • 61 citations

The possible role of angiogenesis in the metastatic potential of human melanoma. Clinicopathological aspects

1993 • 59 citations

Review

1995 • 51 citations

Blood flow in six human melanoma xenograft lines with different growth characteristics.

1992 • 47 citations

Abrogation of B16 Melanoma Metastases by Long-Term Low-Dose Interleukin-6 Therapy

1993 • 21 citations

Improved adenoviral vectors: cautious optimism for gene therapy

1997 • 15 citations