Genomic Instability Induced by Ionizing Radiation

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Radiobiology for the Radiologist.

1974 • 3,582 citations

Structure and function of telomeres

1991 • 3,524 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Growth Factors and Cancer

1991 • 2,044 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

1988 • 1,434 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Artificial transmutation of the gene

1996 • 966 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes

1990 • 614 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

Biochemistry of DNA Lesions

1985 • 445 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation

1994 • 424 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

High-LET radiations induce a large proportion of non-rejoining DNA breaks

1977 • 360 citations

ICE-like proteases in apoptosis

1995 • 353 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

The molecular basis for cell cycle delays following ionizing radiation: a review

1994 • 293 citations

Effects of Radiations of Different Qualities on Cells: Molecular Mechanisms of Damage and Repair

1993 • 286 citations

High Yields of Lethal Mutations in Somatic Mammalian Cells that Survive Ionizing Radiation

1986 • 285 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Some Biochemical Consequences of the Spatial Distribution of Ionizing Radiation-Produced Free Radicals

1981 • 281 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

Delayed Chromosomal Instability Induced by DNA Damage

1993 • 276 citations

Human telomeres: fusion and interstitial sites

1989 • 248 citations

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

1991 • 248 citations

X-Ray-Induced Heritable Damage (Small-Colony Formation) in Cultured Mammalian Cells

1964 • 242 citations

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

1994 • 216 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase

1991 • 205 citations

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

1992 • 200 citations

α-particle-induced chromosomal instability in human bone marrow cells

1994 • 200 citations

Radiation-Induced Genomic Instability: Delayed Mutagenic and Cytogenetic Effects of X Rays and Alpha Particles

1997 • 199 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

H-ras mutations in human pituitary carcinoma metastases.

1994 • 194 citations

Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells.

1993 • 194 citations

Radiation-induced Genomic Instability: Delayed Cytogenetic Aberrations and Apoptosis in Primary Human Bone Marrow Cells

1995 • 181 citations

Genomic Instability and Tumor Progression: Mechanistic Considerations

1992 • 178 citations

Mouse minisatellite mutations induced by ionizing radiation

1993 • 176 citations

Radiation induction of immediate early genes: Effectors of the radiation-stress response

1994 • 174 citations

Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.

1993 • 172 citations

Delayed Reproductive Death in X-irradiated Chinese Hamster Ovary Cells

1991 • 171 citations

TYPES AND RATES OF X-RAY-INDUCED CHROMOSOME ABERRATIONS IN HUMAN BLOOD IRRADIATED IN VITRO

1962 • 166 citations

Identification and characterization of X-ray-induced proteins in human cells.

1989 • 166 citations

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

1992 • 163 citations

Increased Chromosome Aberration Levels in Cells from Mouse Fetuses after Zygote X-irradiation

1989 • 162 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype

1992 • 161 citations

Biological Consequences of Gene Regulation After Ionizing Radiation Exposure

1991 • 160 citations

Cancer Progression and Growth: Relationship of Paracrine and Autocrine Growth Mechanisms to Organ Preference of Metastasis

1993 • 157 citations

Chromosome aberrations and radiation-induced cell death

1973 • 153 citations

The role of the H-ras oncogene in radiation resistance and metastasis

1990 • 145 citations

Chromosomal Aberrations in Human Lymphocytes Inducedin Vitroby Very Low Doses of X-rays

1992 • 142 citations

Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.

1991 • 138 citations

Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures

1993 • 138 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells.

1993 • 136 citations

Radiation Research : A Twentieth-Century Perspective

1992 • 134 citations

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

1989 • 132 citations

New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in ascaris lumbricoides

1991 • 130 citations

Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors.

1993 • 123 citations

Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome.

1994 • 117 citations

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

1992 • 108 citations

A “hot spot” of recombination coincides with an interstitial telomeric sequence in the Armenian hamster

1993 • 108 citations

Radiation-Induced Cellular Reproductive Death and Chromosome Aberrations

1978 • 107 citations

Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts?

1993 • 105 citations

Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective

1995 • 104 citations

Ionizing radiation and genetic risks III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation

1991 • 103 citations

Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells

1996 • 100 citations

Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.

1994 • 95 citations

Chromosomal destabilization during gene amplification.

1990 • 94 citations

Clone-size Analysis in the Study of Cell Growth Following Single or during Continuous Irradiation

1965 • 91 citations

Catalog of chromosome aberrations in cancer, 4th ed

1992 • 87 citations

Radiation-induced Genomic Instability

1994 • 86 citations

DNA Damage Responses: p53 Induction, Cell Cycle Perturbations, and Apoptosis

1994 • 84 citations

Genetic instability as a consequence of inappropriate entry into and Progression through S-phase

1995 • 84 citations

Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation

1992 • 84 citations

Spectrum of X-ray-induced mutations in the human hprt gene

1994 • 81 citations

Failla Memorial Lecture. Changing views of cellular radiosensitivity.

1994 • 79 citations

The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells

1993 • 79 citations

Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation

1993 • 77 citations

Suppression of Gene Amplification in Human Cell Hybrids

1992 • 76 citations

Molecular and cell models of biological effects of heavy ion radiation

1995 • 75 citations

Autocrine growth factors and tumourigenic transformation

1990 • 75 citations

Evidence That DNA Double-Strand Breaks Initiate the Phenotype of Delayed Reproductive Death in Chinese Hamster Ovary Cells

1992 • 75 citations

Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere‐like sequences and chromosome 2 fragile sites

1993 • 73 citations

X-ray induction of methotrexate resistance due todhfr gene amplification

1990 • 68 citations

Dose Assessments by Cytogenetic Analysis in the Goiania (Brazil) Radiation Accident

1988 • 66 citations

Genomic instability: environmental invasion and the enemies within

1998 • 66 citations

DNA-binding protein activated by gamma radiation in human cells.

1990 • 65 citations

Cancer Predisposition, Radiosensitivity and the Risk of Radiation-Induced Cancers. I. Background

1995 • 63 citations

Induction Of Tissue-Type Plasminogen Activator By Ionizing Radiation In Human Malignant Melanoma Cells

1991 • 62 citations

In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays.

1994 • 59 citations

Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor.

1993 • 59 citations

The role of p53 in cell-cycle control and apoptosis: implications for cancer.

1995 • 55 citations

Co-Amplification of rRNA Genes with CAD Genes in N-(Phosphonacetyl)-L-Aspartate-Resistant Syrian Hamster Cells

1983 • 54 citations

Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells.

1993 • 53 citations

Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation.

1994 • 53 citations

RBE—LET Relationships for Different Types of Lethal Radiation Damage in Mammalian Cells: Comparison with DNA Dsb and an Interpretation of Differences in Radiosensitivity

1994 • 53 citations

Proliferation Characteristics of Cultured Mammalian Cells after Irradiation with Sparsely and Densely Ionizing Radiations

1966 • 52 citations

Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells.

1992 • 51 citations

A role for genomic instability in cellular radioresistance?

1995 • 50 citations

Latent expression of p53 mutations and radiation-induced mammary cancer.

1995 • 50 citations

Molecular Mechanisms of Radiation Oncogenesis

1994 • 48 citations

Molecular characterization of a pericentric inversion in mouse chromosome 8 implicates telomeres as promoters of meiotic recombination

1993 • 47 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells.

1993 • 45 citations

Mismatch repair, somatic mutations, and the origins of cancer.

1995 • 45 citations

DNA‐repeat instability is associated with colorectal cancers presenting minimal chromosome rearrangements

1995 • 44 citations

Analysis of X-ray-induced HPRT mutations in CHO cells: Insertion and deletions

1992 • 43 citations

The One-cell Mouse Embryo: Cell Cycle-dependent Radiosensitivity and Development of Chromosomal Anomalies in Postradiation Cell Cycles

1988 • 42 citations

Clonal Heterogeneity in the Progeny of HeLa Cells Which Survive X-irradiation

1994 • 42 citations

Analysis of Structural and Numerical Chromosomal Anomalies at the First, Second, and Third Mitosis after Irradiation of One-cell Mouse Embryos with X-rays or Neutrons

1988 • 42 citations

Telomeres and their possible role in chromosome stabilization

1993 • 41 citations

Mechanisms of X-ray-mediated protooncogene c-iun expression in radiation-induced human sarcoma cell lines

1991 • 40 citations

Chromosomal Instability and Alterations of Telomeric Repeats in Irradiated Human Fibroblasts

1994 • 40 citations

The Influence of Lethal Mutations on the Quantification of Radiation Transformation Frequencies

1987 • 39 citations

Engagement of the CD19 Receptor on Human B-Lineage Leukemia Cells Activates LCK Tyrosine Kinase and Facilitates Radiation-Induced Apoptosis

1993 • 37 citations

Loss of a Putative Tumor Suppressor Locus after Gamma-Ray-Induced Neoplastic Transformation of HeLa × Skin Fibroblast Human Cell Hybrids

1995 • 35 citations

The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation

1994 • 34 citations

Beneficial liaisons: radiobiology meets cellular and molecular biology

1993 • 33 citations

An Examination of the Repair Saturation Hypothesis for Describing Shouldered Survival Curves

1991 • 31 citations

Analysis of Restriction Enzyme-Induced DNA Double-Strand Breaks in Chinese Hamster Ovary Cells by Pulsed-Field Gel Electrophoresis: Implications for Chromosome Damage

1991 • 31 citations

Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

1994 • 30 citations

The role of acentric chromosome fragments in gene amplification

1987 • 30 citations

Immediate X-Ray-Inducible Responses from Mammalian Cells

1994 • 30 citations

Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin.

1995 • 27 citations

Symmetrical chromosome rearrangements in cell lines established from human radiation-induced sarcomas

1990 • 20 citations

Mismatch repair in mammalian cells

1990 • 19 citations

Clonal heterogeneity in delayed decrease of plating efficiency of irradiated HeLa cells

1993 • 18 citations

Mouse minisatellite mutations induced by ionizing radiation

1993 • 17 citations

Loss of Chromosomal Integrity in Neoplasia

1993 • 14 citations

Analysis of Structural and Numerical Chromosomal Aberrations at the First and Second Mitosis after X Irradiation of Two-Cell Mouse Embryos

1989 • 13 citations

Implications of Delayed Reproductive Cell Death (Lethal Mutations/Genomic Instability) for the Interpretation of Tissue Responses

1995 • 12 citations

Mismatch repair as a source of mutations in non-dividing cells

1996 • 11 citations

Induction of CAD gene amplification by restriction endonucleases in V79,B7 Chinese hamster cells

1989 • 11 citations

Chromosomal damage in preimplantation mouse embryos and its development through the cell cycle

1993 • 11 citations

Do DNA Double-Strand Breaks Induced by Alu I Lead to Development of Novel Aberrations in the Second and Third Post-Treatment Mitoses?

1996 • 10 citations

RESTRICTION ENZYME-INDUCED DNA DOUBLE-STRAND BREAKS AS A MODEL TO STUDY THE MECHANISMS OF CHROMOSOMAL ABERRATION FORMATION

1992 • 4 citations

Evidence for Formation of Somatic Cell Hybrids in a Population of Irradiated Cells

1993 • 2 citations