Cytokine Signaling through Stat3 Activates Integrins, Promotes Adhesion, and Induces Growth Arrest in the Myeloid Cell Line 32D
Data up to Jan 2025
Total Citations Per Year
Abstract
References (66)
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 • 200,127 citations
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 • 5,932 citations
STATs and Gene Regulation
1997 • 3,927 citations
A family of cytokine-inducible inhibitors of signalling
1997 • 2,055 citations
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 • 1,970 citations
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 • 1,848 citations
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
1996 • 1,648 citations
Essential role of Stat6 in IL-4 signalling
1996 • 1,563 citations
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
1996 • 1,560 citations
STATs: Signal Transducers and Activators of Transcription
1996 • 1,414 citations
A new protein containing an SH2 domain that inhibits JAK kinases
1997 • 1,413 citations
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
1998 • 1,316 citations
Structure and function of a new STAT-induced STAT inhibitor
1997 • 1,308 citations
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
1997 • 1,306 citations
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 • 1,304 citations
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 • 1,277 citations
Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
1999 • 1,228 citations
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
1993 • 1,223 citations
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 • 1,182 citations
Stat5a is mandatory for adult mammary gland development and lactogenesis.
1997 • 1,106 citations
Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors
1995 • 992 citations
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
1997 • 989 citations
Translational Control of p27 Kip1 Accumulation During the Cell Cycle
1996 • 864 citations
Expression cloning of the murine erythropoietin receptor
1989 • 776 citations
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
1995 • 761 citations
Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice
1999 • 710 citations
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.
1995 • 641 citations
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.
1983 • 559 citations
Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells
1999 • 554 citations
CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation
1997 • 538 citations
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
1999 • 521 citations
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
1999 • 503 citations
The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.
1986 • 487 citations
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
1999 • 481 citations
The dynamic regulation of integrin adhesiveness
1994 • 456 citations
E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1
1998 • 451 citations
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997 • 381 citations
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
1999 • 341 citations
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.
1994 • 332 citations
Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents
1996 • 328 citations
Interleukin-3 signals through multiple isoforms of Stat5.
1995 • 327 citations
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
1995 • 291 citations
STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor
1997 • 263 citations
Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.
1990 • 244 citations
Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.
1991 • 231 citations
The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling
1995 • 217 citations
Adhesion Receptors as Regulators of the Hematopoietic Process
1998 • 208 citations
Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.
1996 • 206 citations
Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.
1994 • 201 citations
Dimeric character of fibronectin, a major cell surface-associated glycoprotein
1977 • 196 citations
Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21WAF1/Cip1 by STAT5
1997 • 189 citations
The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.
1994 • 181 citations
Phosphoinositide 3-OH Kinase Activates the β2Integrin Adhesion Pathway and Induces Membrane Recruitment of Cytohesin-1
1998 • 148 citations
A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.
1990 • 142 citations
Cytokines and STATs: How can signals achieve specificity?
1995 • 132 citations
A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.
1995 • 111 citations
A Role for G-CSF Receptor Signaling in the Regulation of Hematopoietic Cell Function but Not Lineage Commitment or Differentiation
1999 • 91 citations
Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression
1998 • 90 citations
Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors
2000 • 78 citations
Inactivation of the Cyclin D-dependent Kinase in the Rat Fibroblast Cell Line, 3Y1, Induced by Contact Inhibition
1997 • 74 citations
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation
1999 • 73 citations
CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.
1997 • 63 citations
IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with induction of adhesion, but not mitogenesis.
1996 • 37 citations
Release of spleen focus-forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by friend leukemia virus
1980 • 35 citations
Oligomerization and Scaffolding Functions of the Erythropoietin Receptor Cytoplasmic Tail
1999 • 28 citations
Cited By (0)
No citing papers found in database