Alloreactive and Syngeneic CTL Are Comparably Dependent on Interaction with MHC Class I α-Helical Residues

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes

1989 • 339 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens

1982 • 229 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.

1984 • 178 citations

The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands

1996 • 177 citations

Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition

1998 • 163 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule

1990 • 155 citations

Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor

1988 • 151 citations

Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity.

1993 • 150 citations

Alloreactive T cells discriminate among a diverse set of endogenous peptides.

1991 • 136 citations

A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

1993 • 129 citations

Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells

1991 • 124 citations

The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.

1991 • 122 citations

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

1995 • 121 citations

Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.

1991 • 117 citations

Identification of a common docking topology with substantial variation among different TCR–peptide–MHC complexes

1998 • 116 citations

A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

1998 • 110 citations

T-cell lines which cooperate in generation of specific cytolytic activity

1979 • 105 citations

MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions

1997 • 104 citations

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

1995 • 89 citations

Disparate interaction of peptide ligand with nascent versus mature class I major histocompatibility complex molecules: comparisons of peptide binding to alternative forms of Ld in cell lysates and the cell surface.

1992 • 89 citations

Structural diversity of the classical H-2 genes: K, D, and L.

1992 • 83 citations

The three-dimensional structure of an H-2L^d-peptide complex explains the unique interaction of L^dwith beta-2 microglobulin and peptide

1997 • 83 citations

Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor

1996 • 71 citations

Class I-Restricted Alloreactive Cytotoxic T Lymphocytes Recognize a Complex Array of Specific MHC-Associated Peptides

1998 • 62 citations

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition.

1993 • 45 citations

Degenerate Recognition of Alloantigenic Peptides on a Positive-Selecting Class I Molecule

1998 • 44 citations

Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.

1996 • 43 citations

A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.

1996 • 35 citations

The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.

1994 • 35 citations

A cluster of mutations in HLA-A2 ?2 helix abolishes peptide recognition by T cells

1991 • 29 citations

Alloreactive T cell recognition of MHC class I molecules: the T cell receptor interacts with limited regions of the MHC class I long alpha helices.

1997 • 27 citations

Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones.

1993 • 25 citations

Highly diverse T cell recognition of a single Plasmodium berghei peptide presented by a series of mutant H-2Kd molecules.

1992 • 23 citations

Class I-restricted cytotoxic T cell recognition of split peptide ligands

1997 • 19 citations

V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction.

1997 • 15 citations

Sequence restrictions in T cell receptor β-chains that have specificity for a self-peptide/Ld complex

1994 • 11 citations

TAP-Independent MHC Class I Peptide Antigen Presentation to Alloreactive CTL Is Enhanced by Target Cell Incubation at Subphysiologic Temperatures

1998 • 11 citations

Definition of TCR recognition sites on L^d-tum^–complexes

1994 • 11 citations

Strong Alloantigenicity of the α-Helices Residues of the MHC Class I Molecule

1998 • 7 citations

H-2Ld-alloreactive T cell hybridomas utilize diverse Vα and Vβ T cell receptor chains

1996 • 6 citations