Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction

1993 • 3,911 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Measurement of catalase activity in tissue extracts

1970 • 1,183 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

Mechanism of myocardial "stunning".

1990 • 995 citations

Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique

1981 • 925 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Heat-shock response is associated with enhanced postischemic ventricular recovery.

1988 • 489 citations

Myocardial contractile function during ischemia and hypoxia.

1987 • 486 citations

Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism.

1993 • 409 citations

The consequences of expressing hsp70 in Drosophila cells at normal temperatures.

1992 • 398 citations

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene.

1991 • 365 citations

Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection.

1994 • 364 citations

Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

1992 • 336 citations

Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?

1992 • 323 citations

Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.

1994 • 285 citations

Heat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts.

1993 • 278 citations

Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia.

1991 • 265 citations

Examining the function and regulation of hsp 70 in cells subjected to metabolic stress

1992 • 236 citations

Hyperthermia protects mice against the lethal effects of endotoxin

1993 • 185 citations

Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress.

1993 • 176 citations

Acquisition and decay of heat-shock-enhanced postischemic ventricular recovery

1990 • 166 citations

Sublethal ischemia alters myocardial antioxidant activity in canine heart

1993 • 162 citations

Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress.

1993 • 157 citations

Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71.

1986 • 153 citations

Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

1994 • 151 citations

Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock

1994 • 129 citations

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

1994 • 120 citations

Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M.

1988 • 116 citations

Stable High Level Expression of a Transfected Human HSP70 Gene Protects a Heart-Derived Muscle Cell Line Against Thermal Stress

1994 • 106 citations

Heat stress limits infarct size in the isolated perfused rabbit heart

1993 • 85 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 75 citations

The Protective Effect of Heat Stress Against Reperfusion Arrhythmias in the Rat

1993 • 49 citations

Comparison of ischaemic preconditioning in blood perfused and buffer perfused isolated heart models

1993 • 44 citations

Time course of myocardial necrosis

1988 • 33 citations

Role of catalase and heat shock protein on recovery of cardiac endothelial and mechanical function after ischemia.

1993 • 30 citations

Current research views on myocardial reperfusion and reperfusion injury.

1990 • 28 citations

Carnitine palmitoyltransferase in cardiac ischemia. A potential site for altered fatty acid metabolism.

1991 • 28 citations

Interaction between Heat Shock Factor and hsp70 Is Insufficient To Suppress Induction of DNA-Binding Activity In Vivo

1994 • 27 citations

Stress proteins - an endogenous route to myocardial protection: fact or fiction?

1993 • 25 citations

16 Posttranscriptional Regulation of Heat Shock Protein Synthesis in Drosophila

1990 • 24 citations

Protein degradation and synthesis during recovery from myocardial ischemia

1981 • 15 citations