Control of gene transcription by Jun and Fos proteins in the nervous system

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level

1988 • 1,916 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat

1990 • 1,009 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa

1979 • 651 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

1985 • 589 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord

1990 • 527 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Expression of c‐fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation

1989 • 500 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Proceedings of the VIth World Congress on Pain

1991 • 348 citations

Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat

1988 • 348 citations

Specific temporal and spatial distribution of JUN, FOS, and KROX‐24 proteins in spinal neurons following noxious transsynaptic stimulation

1991 • 338 citations

jun:Oncogene and Transcription Factor

1990 • 337 citations

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

1993 • 323 citations

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

1990 • 314 citations

Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord

1989 • 311 citations

Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat

1992 • 298 citations

Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

1993 • 293 citations

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

1988 • 292 citations

Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat

1984 • 274 citations

Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene

1991 • 272 citations

Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damage

1991 • 249 citations

Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation

1989 • 236 citations

Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process

1991 • 235 citations

Primary sensory neurones: Neurofilament, neuropeptides and conduction velocity

1993 • 199 citations

The transcription factors c-JUN, JUN D and CREB, but not FOS and KROX-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve

1992 • 199 citations

Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord

1989 • 195 citations

Mechanisms of complex transcriptional regulation: implications for brain development

1991 • 193 citations

Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats

1989 • 185 citations

Tonotopic Order in the Adult and Developing Auditory System of the Rat as Shown by c‐fos Immunocytochemistry

1992 • 184 citations

Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain

1979 • 176 citations

JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: Basal expression and induction by spreading depression and epileptic seizures

1993 • 174 citations

Long-lasting increase of nitric oxide synthase immunoreactivity, NADPH-diaphorase reaction and c-JUN co-expression in rat dorsal root ganglion neurons following sciatic nerve transection

1993 • 174 citations

Tissue-specific expression of c-jun and junB during organogenesis in the mouse

1989 • 172 citations

Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy

1993 • 171 citations

Stimulus-induced coordinate changes in mRNA abundance in single postsynaptic hippocampal CA1 neurons

1992 • 159 citations

On the Role of Galanin, Substance P and Other Neuropeptides in Primary Sensory Neurons of the Rat: Studies on Spinal Reflex Excitability and Peripheral Axotomy

1990 • 149 citations

Induction of c‐fos mRNA Expression by Afterdischarge in the Hippocampus of Naive and Kindled Rats

1990 • 146 citations

Induction of immediate early gene encoded proteins in the rat hippocampus after bicuculline-induced seizures: Differential expression of KROX-24, FOS and JUN proteins

1992 • 142 citations

Learning‐induced Increase of Immediate Early Gene Messenger RNA in the Chick Forebrain

1991 • 141 citations

Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-d-aspartate receptor antagonist MK-801

1993 • 137 citations

Changing pattern Of C-FOS expression in spinal cord neurons after electrical stimulation of the chronically injured sciatic nerve in the rat

1992 • 131 citations

Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw

1994 • 128 citations

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 126 citations

Mechanisms of trans-synaptic regulation of gene expression

1987 • 125 citations

Prodynorphin gene expression is enhanced in the spinal cord of chronic arthritic rats

1987 • 122 citations

Expression of JUN, KROX, and CREB transcription factors in goldfish and rat retinal ganglion cells following optic nerve lesion is related to axonal sprouting

1993 • 113 citations

Expression of c-JUN, JUN B and JUN D proteins in rat nervous system following transection of vagus nerve and cervical sympathetic trunk

1991 • 110 citations

Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy

1991 • 105 citations

Gene regulation in an ascending nociceptive pathway: inflammation- induced increase in preprotachykinin mRNA in rat lamina I spinal projection neurons

1992 • 104 citations

Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: Cascade of transcriptional operations during nociception

1991 • 102 citations

Induction of FOS and JUN proteins after focal ischemia in the rat: differential effect of the N-methyl-d-aspartate receptor antagonist MK-801

1992 • 101 citations

Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord

1989 • 99 citations

Proto-oncogenes in the nervous system

1988 • 98 citations

Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system

1993 • 94 citations

Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation

1993 • 93 citations

Differential time course and spatial expression of Fos, Jun, and Krox‐24 proteins in spinal cord of rats undergoing subacute or chronic somatic inflammation

1993 • 89 citations

The KROX-24 protein, a new transcription regulating factor: Expression in the rat central nervous system following afferent somatosensory stimulation

1990 • 83 citations

c-JUN-like immunoreactivity in the CNS of the adult rat: Basal and transynaptically induced expression of an immediate-early gene

1991 • 81 citations

Growth Factor Inducible Genes in Fibroblasts

1990 • 81 citations

Differential expression of c-fos and c-jun in two regions of the rat spinal cord following noxious colorectal distention

1993 • 76 citations

Nitric oxide mediates Fos expression in the spinal cord induced by mechanical noxious stimulation

1992 • 75 citations

Memory processing and apamin induce immediate early gene expression in mouse brain

1993 • 73 citations

Changes of reflexes in vasoconstrictor neurons supplying the cat hindlimb following chronic nerve lesions: a model for studying mechanisms of reflex sympathetic dystrophy?

1983 • 72 citations

Structure and mapping of thefosB gene. FosB downregulates the activity of thefosB promotero

1992 • 71 citations

Colocalisation and covariation of c-JUN transcription factor with galanin in primary afferent neurons and with CGRP in spinal motoneurons following transection of rat sciatic nerve

1993 • 66 citations

Application of morphine prior to noxious stimulation differentially modulates expression of Fos, Jun and Krox-24 proteins in rat spinal cord neurons

1994 • 66 citations

c-jun Expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat

1993 • 65 citations

Co-induction of jun B and c-fos in a subset of neurons in the spinal cord.

1991 • 60 citations

Growth factors, differentiation factors and cytokines

1990 • 56 citations

C-fos induction in the spinal cord following noxious stimulation: Prevention by opiates but not by nmda antagonists

1990 • 56 citations

Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat

1988 • 53 citations

Bombesin induces c-fos and c-myc expression in quiescent Swiss 3T3 cells

1987 • 52 citations

Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells

1993 • 52 citations

MK801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 51 citations

The KROX-20 transcription factor in the rat central and peripheral nervous systems: novel expression pattern of an immediate early gene-encoded protein

1993 • 50 citations

c-src and other proto-oncogenes implicated in neuronal differentiation

1989 • 49 citations

Monoarthritis induces complex changes in μ-, δ- and κ-opioid binding sites in the superficial dorsal horn of the rat spinal cord

1992 • 43 citations

Enkephalin, substance P, and serotonin axonal input to c-fos-like immunoreactive neurons of the rat spinal cord

1991 • 35 citations

Physiological and Pharmacological Induction of C-FOS Protein Immunoreactivity in Superficial Dorsal Horn Neurones

1989 • 20 citations