Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat

1990 • 1,009 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents

1984 • 719 citations

Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist

1988 • 676 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus

1987 • 579 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord

1990 • 527 citations

The spino(trigemino)pontoamygdaloid pathway: electrophysiological evidence for an involvement in pain processes

1990 • 440 citations

α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating

1989 • 417 citations

Diencephalic mechanisms of pain sensation

1985 • 412 citations

Specific temporal and spatial distribution of JUN, FOS, and KROX‐24 proteins in spinal neurons following noxious transsynaptic stimulation

1991 • 338 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

1988 • 292 citations

Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene

1991 • 272 citations

Dexmedetomidine, an α2-Adrenoceptor Agonist, Reduces Anesthetic Requirements for Patients Undergoing Minor Gynecologic Surgery

1990 • 270 citations

Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones

1985 • 246 citations

Spinal lamina I projection neurons in the rat: Collateral innervation of parabrachial area and thalamus

1989 • 219 citations

Morphine or U‐50,488 suppresses fos protein‐like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat

1992 • 210 citations

The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: Correlation of nociceptive behavior and c-fos expression

1991 • 207 citations

The analgesic action of dexmedetomidine — a novel α2-adrenoceptor agonist — in healthy volunteers

1991 • 204 citations

Structure and function of alpha-adrenoceptors.

1991 • 201 citations

Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole.

1989 • 180 citations

Preproenkephalin mrna in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins

1992 • 165 citations

Spinal Antinociception by Dexmedetomidine, a Highly Selective α₂‐Adrenergic Agonist

1991 • 154 citations

EVIDENCE FOR MEDETOMIDINE AS A SELECTIVE AND POTENT AGONIST α₂‐ADRENORECEPTORS

1986 • 145 citations

Induction of immediate early gene encoded proteins in the rat hippocampus after bicuculline-induced seizures: Differential expression of KROX-24, FOS and JUN proteins

1992 • 142 citations

Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine

1991 • 138 citations

Adrenergic receptors mediate changes in c-fos mRNA levels in brain

1989 • 126 citations

Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative

1988 • 118 citations

Behavioural and neurochemical effects of antipamezole, a novel α2-adrenoceptor antagonist

1988 • 112 citations

Distribution of α2-adrenergic receptor mRNAs in the rat CNS

1991 • 109 citations

Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation

1990 • 107 citations

Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: Cascade of transcriptional operations during nociception

1991 • 102 citations

Involvement of supraspinal and spinal segmental alpha-2-adrenergic mechanisms in the medetomidine-induced antinociception

1991 • 100 citations

Effect of Systemic Medetomidine, an Alpha2 Adrenoceptor Agonist, on Experimental Pain in Humans

1991 • 97 citations

Noradrenergic activation of immediate early genes in rat cerebral cortex

1991 • 96 citations

The KROX-24 protein, a new transcription regulating factor: Expression in the rat central nervous system following afferent somatosensory stimulation

1990 • 83 citations

Rat Spinal Cord α₂‐Adrenoceptors are of the α_2A‐Subtype: Comparison with α_2A‐ and α_2B‐Adrenoceptors in Rat Spleen, Cerebral Cortex and Kidney Using ³H‐RX821002 Ligand Binding

1991 • 79 citations

Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist.

1991 • 78 citations

Behavioural and neurochemical effects of atipamezole, a novel α2-adreneceptor antagonist

1988 • 75 citations

Antinociceptive properties of intrathecal dexmedetomidine in rats

1991 • 70 citations

Putative nociceptive modulatory neurons in the dorsolateral pontomesencephalic reticular formation

1989 • 69 citations

The use of medetomidine, medetomidine-ketamine combinations and atipamezole at Helsinki Zoo--a review of 240 cases.

1989 • 66 citations

The effect of medetomidine, an α2-adrenoceptor agonist, in various pain tests

1990 • 61 citations

Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms

1992 • 42 citations

FLFQPQRF-amide modulatesα2-adrenergic antinociception in the rat dorsal horn in vivo

1991 • 27 citations

Antinociception in bulboreticular neurons of the rat produced by spinally administered medetomidine, an α2-adrenoceptor agonist

1991 • 13 citations

Influence of clonidine and morphine on spinal afferent transmission

1992 • 3 citations