Ribozymes: A Distinct Class of Metalloenzymes

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1990 • 1,270 citations

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

A general two-metal-ion mechanism for catalytic RNA.

1993 • 1,125 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures

1992 • 725 citations

The Intervening Sequence RNA of Tetrahymena Is an Enzyme

1986 • 498 citations

On the origin of RNA splicing and introns

1985 • 483 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

A self-splicing RNA excises an intron lariat

1986 • 449 citations

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

1992 • 438 citations

Metal ion catalysis in the Tetrahymena ribozyme reaction

1993 • 386 citations

Defining the Inside and Outside of a Catalytic RNA Molecule

1989 • 368 citations

Role of divalent metal ions in the hammerhead RNA cleavage reaction

1991 • 365 citations

RNA catalytic properties of the minimum (-)sTRSV sequence

1989 • 360 citations

Visualizing the Higher Order Folding of a Catalytic RNA Molecule

1991 • 354 citations

A crystallographic study of metal-binding to yeast phenylalanine transfer RNA

1977 • 322 citations

Stability constants of magnesium and cadmium complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of magnesium-ATP and magnesium-ADP

1984 • 288 citations

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

1986 • 285 citations

Human hepatitis delta virus RNA subfragments contain an autocleavage activity.

1989 • 284 citations

Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site

1990 • 280 citations

Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA

1985 • 260 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

Role of the Protein Moiety of Ribonuclease P, a Ribonucleoprotein Enzyme

1988 • 225 citations

RNA - ligand interactions:(I) magnesium binding sites in yeast tRNA^Phe

1977 • 221 citations

A small metalloribozyme with a two-step mechanism

1992 • 212 citations

Aminoacyl Esterase Activity of the Tetrahymena Ribozyme

1992 • 204 citations

Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria)

1991 • 201 citations

In vitro selection of RNAs that undergo autolytic cleavage with lead(2+)

1992 • 197 citations

Evolution in vitro of an RNA enzyme with altered metal dependence

1993 • 191 citations

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme

1992 • 182 citations

Reverse self-splicing of the tetrahymena group I intron: Implication for the directionality of splicing and for intron transposition

1989 • 178 citations

Self-cleavage of RNA in the replication of small pathogens of plants and animals

1989 • 177 citations

Group II intron self-splicing. Alternative reaction conditions yield novel products.

1988 • 175 citations

Modified nucleosides in transfer RNA

1977 • 171 citations

How many catalytic RNAs? Ions and the Cheshire cat conjecture.

1993 • 165 citations

Specific cleavage of a protein by an attached iron chelate

1990 • 164 citations

Group II Intron Domain 5 Facilitates a trans-Splicing Reaction

1988 • 161 citations

In vitro genetics

1992 • 159 citations

Lead-catalyzed cleavage of yeast tRNAPhe mutants

1990 • 156 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Effects of metal ions, including Mg2+ and lanthanides, on the cleavage of ribonucleotides and RNA model compounds.

1991 • 148 citations

Directed Molecular Evolution

1992 • 147 citations

Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme

1989 • 139 citations

Clustering of modified nucleotides at the functional center of bacterial ribosomal RNA.

1993 • 134 citations

New strategy for selective protein cleavage

1990 • 134 citations

Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

1990 • 132 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis.

1992 • 127 citations

Metal coordination sites that contribute to structure and catalysis in the group I intron from Tetrahymena

1993 • 126 citations

Selection of a Ribozyme That Functions as a Superior Template in a Self-Copying Reaction

1992 • 126 citations

Site-specific cleavage of the protein calmodulin using a trifluoperazine-based affinity reagent

1990 • 119 citations

Site-specific cleavage by metal ion cofactors and inhibitors of M1 RNA, the catalytic subunit of RNase P from Escherichia coli.

1991 • 112 citations

RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.

1992 • 108 citations

Ionic requirements for RNA binding, cleavage, and ligation by the hairpin ribozyme

1993 • 104 citations

Ribonuclease P: function and variation.

1990 • 104 citations

Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns

1992 • 103 citations

RNA as an RNA Polymerase: Net Elongation of an RNA Primer Catalyzed by the Tetrahymena Ribozyme

1988 • 98 citations

Nuclear magnetic resonance studies of the hammerhead ribozyme domain

1991 • 96 citations

Binding and cleavage of nucleic acids by the "hairpin" ribozyme

1991 • 95 citations

Reverse self-splicing of group II intron RNAs in vitro

1990 • 94 citations

Analysis of the role of phosphate oxygens in the group I intron from Tetrahymena

1992 • 93 citations

Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design

1992 • 93 citations

DNA footprinting with hydroxyl radical

1988 • 89 citations

Efficient Trans-Splicing of a Yeast Mitochondrial RNA Group II Intron Implicates a Strong 5′ Exon-Intron Interaction

1986 • 77 citations

Regenerating good sense: RNA editing and trans splicing in plant mitochondria

1992 • 75 citations

New reactions catalyzed by a group II intron ribozyme with RNA and DNA substrates

1992 • 63 citations

Theoretical analyses on the role of Mg2+ ions in ribozyme reactions.

1993 • 61 citations

Effects of substrate structure on the kinetics of circle opening reactions of the self-splicing intervening sequence fromTetrahymena thermophila: evidence for substrate and Mg²⁺binding lnteractions

1989 • 61 citations

Reaction conditions and kinetics of self-cleavage of a ribozyme derived from Neurospora VS RNA

1993 • 60 citations

A trinucleotide can promote metal ion-dependent specific cleavage of RNA.

1992 • 59 citations

A Mn ²⁺ -Dependent Ribozyme

1990 • 58 citations

Probing the environment of lanthanide binding sites in yeast tRNA^Phe by specific metal‐ion‐promoted cleavages

1989 • 56 citations

The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase

1986 • 54 citations

Characterization of Two RNA-catalyzed RNA Cleavage Reactions

1987 • 52 citations

A Ribonucleoprotein Which Catalyzes Thiol-Disulfide Exchange in the Sea Urchin Egg

1967 • 39 citations

The potential use of catalytic RNAs in therapy of HIV infection and other diseases

1991 • 39 citations

A computational approach to the mechanism of self-cleavage of hammerhead RNA.

1989 • 38 citations

Metal ion and substrate structure dependence of the processing of tRNA precursors by RNase P and M1 RNA.

1990 • 15 citations

Catalytic RNA reactions of yeast tRNAPhe fragments

1992 • 13 citations