Prediction of Cancer Driver Mutations in Protein Kinases

Basic local alignment search tool

1990 • 87,358 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

2005 • 3,807 citations

A census of human cancer genes

2004 • 3,190 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

1993 • 1,835 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

2004 • 1,208 citations

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

2001 • 1,148 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.

1993 • 835 citations

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

2006 • 712 citations

BAY 43-9006 Inhibition of Oncogenic RET Mutants

2006 • 466 citations

Targeting Tyrosine Kinases in Cancer: The Second Wave

2006 • 464 citations

The mutation rate and cancer

1996 • 459 citations

Gibbs motif sampling: Detection of bacterial outer membrane protein repeats

1995 • 400 citations

Polyclonal Evolution of Multiple Secondary KIT Mutations in Gastrointestinal Stromal Tumors under Treatment with Imatinib Mesylate

2006 • 355 citations

Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib

2003 • 321 citations

Structural and Functional Diversity of the Microbial Kinome

2007 • 268 citations

Activation Loop Phosphorylation and Catalysis in Protein Kinases: Is There Functional Evidence for the Autoinhibitor Model?

2002 • 229 citations

Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer

2006 • 176 citations

CanPredict: a computational tool for predicting cancer-associated missense mutations

2007 • 153 citations

Distinguishing Cancer-Associated Missense Mutations from Common Polymorphisms

2007 • 125 citations

Crystal Structure of the T315I Mutant of Abl Kinase

2007 • 101 citations

EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer

2006 • 86 citations

APDB: a novel measure for benchmarking sequence alignment methods without reference alignments

2003 • 78 citations

Different Effects of Point Mutations within the B-Raf Glycine-Rich Loop in Colorectal Tumors on Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase and Nuclear Factor κB Pathway and Cellular Transformation

2004 • 73 citations

Accurate prediction of deleterious protein kinase polymorphisms

2007 • 61 citations

The second wave in kinase cancer drugs

2006 • 58 citations

EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy

2007 • 37 citations

Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model

2004 • 36 citations

Distribution analysis of nonsynonymous polymorphisms within the human kinase gene family

2007 • 30 citations

Structural Analysis of Protein Kinase A Mutants with Rho-kinase Inhibitor Specificity

2006 • 30 citations

Two mutations affecting conserved residues in the Met receptor operate via different mechanisms

2000 • 27 citations

Nucleotide-Induced Conformational Changes in the Saccharomyces cerevisiae SR Protein Kinase, Sky1p, Revealed by X-ray Crystallography

2003 • 25 citations

A future of cancer prevention and cures: highlights of the Centennial Meeting of the American Association for Cancer Research

2007 • 9 citations

Deleted Work

1955 • 0 citations