Back to search

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

Data up to Jan 2025

Published2007
Citations218
References66

Total Citations Per Year

Abstract

References (66)

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Why do cancers have high aerobic glycolysis?

2004 • 4,534 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

1998 • 1,506 citations

Glycolysis inhibition for anticancer treatment

2006 • 1,434 citations

Akt Stimulates Aerobic Glycolysis in Cancer Cells

2004 • 1,408 citations

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

1919 • 1,388 citations

Oncogenic alterations of metabolism

1999 • 1,095 citations

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

2000 • 816 citations

Acid-Mediated Tumor Invasion: a Multidisciplinary Study

2006 • 744 citations

Fundamental Concepts of the Angiogenic Process

2003 • 657 citations

Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development

2005 • 651 citations

Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice

2006 • 641 citations

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

2000 • 641 citations

The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion

1919 • 637 citations

A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion

2005 • 579 citations

A reaction-diffusion model of cancer invasion.

1996 • 579 citations

Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography

2002 • 536 citations

MRI of the tumor microenvironment

2002 • 530 citations

Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch

2006 • 483 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 366 citations

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells.

1994 • 360 citations

Positron Emission Tomography Scanning: Current and Future Applications

2002 • 330 citations

An evolutionary model of carcinogenesis.

2003 • 326 citations

Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography

2002 • 306 citations

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

2006 • 257 citations

Contributions of Cell Metabolism and H+ Diffusion to the Acidic pH of Tumors

2003 • 250 citations

[18F]FMISO and [18F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression

2003 • 250 citations

Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells

2002 • 249 citations

Expression of the Hypoxia-Inducible and Tumor-Associated Carbonic Anhydrases in Ductal Carcinoma in Situ of the Breast

2001 • 247 citations

Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

2005 • 239 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 234 citations

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.

2003 • 210 citations

Involvement of Hypoxia-Inducible Factor 1 in Human Cancer.

2002 • 206 citations

‘The Metabolism of Tumours’: 70 Years Later

2001 • 201 citations

Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism.

1997 • 178 citations

Glucose Metabolism Heterogeneity in Human and Mouse Malignant Glioma Cell Lines

2005 • 174 citations

Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells

1991 • 168 citations

Characterization of very acidic phagosomes in breast cancer cells and their association with invasion

1994 • 165 citations

Biological and Clinical Significance of Cathepsin D in Breast Cancer Metastasis

1996 • 151 citations

The role of acidity in solid tumour growth and invasion

2005 • 150 citations

Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET.

2006 • 138 citations

Combined vascular and extracellular pH imaging of solid tumors

2002 • 131 citations

Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats

1999 • 125 citations

Oncogenes in tumor metabolism, tumorigenesis, and apoptosis.

1997 • 120 citations

Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia?

2004 • 111 citations

Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis

2005 • 111 citations

Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation

2002 • 97 citations

Comparing Techniques of Measuring Tumor Hypoxia in Different Murine Tumors: Eppendorf pO 2 Histograph, [ 3 H]Misonidazole Binding and Paired Survival Assay

1996 • 81 citations

PET in clinical oncology

1988 • 80 citations

Why Are Cancers Acidic? A Carrier‐Mediated Diffusion Model for H + Transport in the Interstitial Fluid

2001 • 72 citations

Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies

2005 • 71 citations

Heterogeneity of tumor oxygenation: relationship to tumor necrosis, tumor size, and metastasis

1998 • 68 citations

An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.

1997 • 67 citations

Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy.

1998 • 61 citations

Detection of Resistance to Imatinib by Metabolic Profiling

2005 • 61 citations

Cervix cancer oxygenation measured following external radiation therapy

1998 • 57 citations

Fluctuations inpO2in Irradiated Human Melanoma Xenografts

2006 • 48 citations

pH, Hypoxia and Metastasis

2001 • 48 citations

Alterations and Role of Human Cathepsin D in Cancer Metastasis

1996 • 44 citations

The Physiological Environment in Cancer Vascularization, Invasion and Metastasis

2001 • 39 citations

Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

1979 • 20 citations

The Physiologic Effects of Laparoscopy

2005 • 16 citations

New directions for radiation biology research in cancer of the uterine cervix.

1996 • 14 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? (2007) – Journal of Bioenergetics and Biomembranes | Metascience Observatory Explorer