An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.

1995 • 1,271 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm3-transfected melanoma cells

1991 • 548 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.

1994 • 433 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

1993 • 428 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

1988 • 380 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

1993 • 283 citations

Hypoxia and radiation response in human tumors

1996 • 279 citations

Association Between Expression of Activated 72-Kilodalton Gelatinase and Tumor Spread in Non-Small-Cell Lung Carcinoma

1993 • 278 citations

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells

1995 • 269 citations

Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

1990 • 238 citations

Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.

1992 • 228 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo

1996 • 195 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis

1981 • 182 citations

Expression and activity of MMPS and their regulators in ovarian cancer

1994 • 168 citations

Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells

1991 • 168 citations

Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas

1996 • 165 citations

Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion.

1996 • 150 citations

Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines.

1992 • 147 citations

Reduced malignancy of ras-transformed NIH 3T3 cells expressing antisense osteopontin RNA.

1994 • 146 citations

Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors

1993 • 141 citations

Suppression of Invasion by Inducible Expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in B 16-F10 Melanoma Cells

1992 • 137 citations

Expression of activated gelatinase in human invasive breast carcinoma

1993 • 135 citations

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1992 • 134 citations

Secretion of matrix metalloproteinases and their inhibitors (tissue inhibitor of metalloproteinases) by human prostate in explant cultures: reduced tissue inhibitor of metalloproteinase secretion by malignant tissues.

1993 • 119 citations

Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.

1989 • 119 citations

Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential

1990 • 119 citations

Secreted phosphoprotein mrna is induced during multi‐stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

1990 • 118 citations

Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors.

1993 • 113 citations

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells.

1995 • 102 citations

Effects of cytokine‐mediated modulation of nm23 expression on the invasion and metastatic behavior of B16F10 melanoma cells

1995 • 99 citations

Induction of expression of osteopontin (OPN; secreted phosphoprotein) in metastatic, ras-transformed NIH 3T3 cells.

1992 • 97 citations

Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras‐transformed NIH 3T3 cells

1992 • 91 citations

The potential roles of nm23 in cancer metastasis and cellular differentiation

1995 • 85 citations

Induction of fibroblast 92 kDa gelatinase/type iv collagenase expression by direct contact with metastatic tumor cells

1994 • 84 citations

Quantitative genetic analysis of tumor progression

1985 • 83 citations

Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo

1992 • 76 citations

Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme

1995 • 76 citations

Normal Fibroblasts Responding to Anoxia Exhibit Features of the Malignant Phenotype

1989 • 58 citations

Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.

1990 • 47 citations

Enhanced levels of cathepsin B mRNA in murine tumors

1989 • 45 citations

Benign-to-Malignant B16 melanoma Progression Induced in Two Stages In Vitro by Exposure to Hypoxi

1994 • 41 citations

Dynamic heterogeneity: isolation of murine tumor cell populations enriched for metastatic variants and quantification of the unstable expression of the phenotype

1986 • 39 citations

Expression of 72 kDa and 92 kDa type IV collagenases from human giant-cell tumor of bone

1995 • 26 citations

Influence of fibroblasts on the invasion and migration of highly or weakly metastatic b16 melanoma cells

1994 • 26 citations

Effects of reoxygenation on cells from hypoxic regions of solid tumors: analysis of transplanted murine tumors for evidence of DNA overreplication.

1990 • 22 citations

The malignant phenotype and cysteine proteinases.

1991 • 22 citations

Cysteine Endopeptidases and Their Inhibitors in Malignant Progression of Rat Embryo Fibroblasts

1992 • 20 citations

Tumor-host interactions in the rabbit V2 carcinoma: stimulation of cathepsin B in host fibroblasts by a tumor-derived cytokine.

1988 • 20 citations

Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.

1990 • 18 citations