Injury-Induced Immune Dysfunction: Is the Lymphocyte Irrelevant?

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

2000 • 524 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Immunodepression after major surgery in normal patients.

1975 • 424 citations

Host Resistance in Sepsis and Trauma

1975 • 259 citations

Depression of Cellular Immunity After Major Injury

1986 • 252 citations

The Immunologic Response To Injury

2001 • 233 citations

Major Injury Induces Increased Production of Interleukin-10 by Cells of the Immune System With a Negative Impact on Resistance to Infection

1997 • 221 citations

Phase I trial of subcutaneous recombinant human interleukin-12 in patients with advanced renal cell carcinoma.

1998 • 219 citations

Inadequate Interleukin 2 Production

1984 • 211 citations

HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection

1991 • 207 citations

Testosterone Receptor Blockade After Hemorrhage in Males

1997 • 204 citations

Depressed Interferon Gamma Production and Monocyte HLA-DR Expression After Severe Injury

1988 • 195 citations

POSTOPERATIVE DEPRESSION OF THE LYMPHOCYTE RESPONSE TO PHYTOHÆMAGGLUTININ

1967 • 190 citations

Mechanism of Immunosuppression in Males Following Trauma-Hemorrhage

1996 • 178 citations

Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage

1994 • 168 citations

Interferon Gamma-1b in the Treatment of Compensatory Anti-inflammatory Response Syndrome

1997 • 155 citations

Interleukin-10 Is Associated with the Development of Sepsis in Trauma Patients

1996 • 149 citations

Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model.

1988 • 135 citations

Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.

1997 • 129 citations

Injury Induces Deficient Interleukin-12 Production, But Interleukin-12 Therapy After Injury Restores Resistance to Infection

2000 • 128 citations

Dominance of T-Helper 2–Type Cytokines After Severe Injury

1996 • 123 citations

Hypertonic Saline Resuscitation Restores Hemorrhage-Induced Immunosuppression by Decreasing Prostaglandin E2and Interleukin-4 Production

1996 • 115 citations

The Role of Prostaglandin E2 in Immune Suppression Following Injury

1991 • 110 citations

Role of Operative Stress on the Resistance of the Experimental Animal to Inoculated Cancer Cells

1958 • 110 citations

Role of elevated monocyte transforming growth factor? (TGF?) production in posttrauma immunosuppression

1991 • 109 citations

Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury

1996 • 107 citations

FLUTAMIDE

1997 • 100 citations

Association of Interleukin-4 Plasma Levels With Traumatic Injury and Clinical Course

1995 • 99 citations

Cell-Mediated Immunity after Thermal Injury

1973 • 99 citations

Anergy, Immunosuppressive Serum, and Impaired Lymphocyte Blastogenesis in Burn Patients

1982 • 99 citations

Anti-interleukin-10 antibody restores burn-induced defects in T-cell function

1997 • 94 citations

Is Circulating Endotoxin the Trigger for the Systemic Inflammatory Response Syndrome Seen After Injury?

1997 • 83 citations

SEVERE INJURY TRIGGERS ANTIGEN-SPECIFIC T-HELPER CELL DYSFUNCTION

1999 • 73 citations

CD4+ contrasuppressor T cells improve the resistance of thermally injured mice infected with HSV

1995 • 60 citations

Melatonin Administration Following Hemorrhagic Shock Decreases Mortality from Subsequent Septic Challenge

1996 • 56 citations

Prolactin: A Novel and Safe Immunomodulating Hormone for the Treatment of Immunodepression Following Severe Hemorrhage

1996 • 55 citations

PROLONGED SURVIVAL OF A SKIN HOMOGRAFT IN A PATIENT WITH VERY EXTENSIVE BURNS

1957 • 50 citations

Effects of Antimurine Interleukin-6 on Bacterial Translocation During Gut-Derived Sepsis

1994 • 48 citations

INJURY PRIMES THE IMMUNE SYSTEM FOR AN ENHANCED AND LETHAL T-CELL RESPONSE AGAINST BACTERIAL SUPERANTIGEN

1999 • 45 citations

Altered IL-10 levels in trauma patients' M� and T lymphocytes

1995 • 44 citations

Delayed hypersensitivity status of burned patients.

1966 • 39 citations

Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle

1997 • 34 citations

Burn injury primes naive CD4+ T cells for an augmented T-helper 1 response

1998 • 33 citations

Granulocyte–macrophage colony-stimulating factor modulates immune function and improves survival after experimental thermal injury

1995 • 32 citations

IFN-γ Decreases Translocation and Improves Survival Following Transfusion and Thermal Injury

1994 • 28 citations

Burn injury primes naive CD4+ T cells for an augmented T-helper 1 response

1998 • 3 citations