Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Organogenesis of the kidney

1987 • 904 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Functions of FGF signalling from the apical ectodermal ridge in limb development

2002 • 554 citations

Organogenesis of the Kidney

1987 • 473 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects inBMP7 deficient embryos

1997 • 448 citations

Fgf8 signalling from the AER is essential for normal limb development

2000 • 444 citations

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

1998 • 437 citations

Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter

2000 • 407 citations

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

2002 • 381 citations

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

2003 • 367 citations

WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo

2001 • 360 citations

Murine homolog ofSALL1is essential for ureteric bud invasion in kidney development

2001 • 342 citations

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

1999 • 337 citations

Fgf8 is required for outgrowth and patterning of the limbs

2000 • 319 citations

Control of Vertebrate Limb Outgrowth by the Proximal Factor Meis2 and Distal Antagonism of BMPs by Gremlin

1999 • 317 citations

EctodermalWnt3/β-cateninsignaling is required for the establishment and maintenance of the apical ectodermal ridge

2003 • 298 citations

A re-examination of proximodistal patterning during vertebrate limb development

2002 • 297 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Formins: signaling effectors for assembly and polarization of actin filaments

2003 • 282 citations

Tube or Not Tube

2003 • 264 citations

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

1996 • 245 citations

BMPs negatively regulate structure and function of the limb apical ectodermal ridge

1999 • 232 citations

Comparative Genomic Analysis of the Eight-Membered Ring Cystine Knot-Containing Bone Morphogenetic Protein Antagonists

2003 • 230 citations

Coordinating early kidney development: lessons from gene targeting

2002 • 224 citations

Patterning Systems—From One End of the Limb to the Other

2003 • 224 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb

2001 • 181 citations

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

2004 • 142 citations

Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal–ventral axis in the limb

2003 • 135 citations

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

2000 • 132 citations

Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

2000 • 110 citations

The bone morphogenic protein antagonist gremlin regulates proximal‐distal patterning of the lung

2001 • 108 citations

Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis

2001 • 99 citations

Glial Cell Line-Derived Neurotrophic Factor Stimulates Ureteric Bud Outgrowth and Enhances Survival of Ureteric Bud Cells in vitro

1998 • 88 citations

The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′ HoxD genes during limb pattern formation

1995 • 72 citations

Formin defines a large family of morphoregulatory genes and functions in establishment of the polarising region

1999 • 69 citations

Protein Kinase A Is a Negative Regulator of Renal Branching Morphogenesis and Modulates Inhibitory and Stimulatory Bone Morphogenetic Proteins

1999 • 66 citations

Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation

1994 • 58 citations

Patterning the limb before and after SHH signalling

2003 • 55 citations

Organisation of Bone Morphogenetic Proteins in Renal Development

2003 • 17 citations