Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

The Hallmarks of Cancer

2000 • 27,569 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

2002 • 1,805 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 • 1,035 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

2001 • 545 citations

NF-κB, chemokine gene transcription and tumour growth

2002 • 507 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

2001 • 481 citations

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.

1999 • 478 citations

The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B.

1992 • 416 citations

A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation

1998 • 397 citations

p53 stabilization is decreased upon NFκB activation

2002 • 311 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

2002 • 268 citations

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

1999 • 265 citations

Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

2001 • 263 citations

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF‐κB and AP‐1 activation and IL‐8 and VEGF expression in human head and neck squamous cell carcinoma lines

2002 • 230 citations

Constitutive activation of transcription factors NF-?B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

1999 • 221 citations

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

1998 • 220 citations

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

1999 • 204 citations

Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism

2000 • 176 citations

The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.

1999 • 151 citations

The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68

1997 • 148 citations

Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma

2003 • 136 citations

Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway.

2001 • 132 citations

NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

2003 • 120 citations

Immunohistochemical detection of p53 protein accumulation in head and neck cancer: Correlation with p53 gene alterations

1999 • 103 citations

Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

2001 • 89 citations

Immunohistochemical staining for glutathione S-transferase predicts response to platinum-based chemotherapy in head and neck cancer.

1996 • 83 citations

Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression.

1995 • 66 citations

Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death

2000 • 65 citations

Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity

1996 • 62 citations

Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.

1997 • 52 citations

Point Mutation in Essential Genes with Loss or Mutation of the Second Allele

2001 • 47 citations

RelA suppresses the Wnt/β-catenin pathway without exerting trans-acting transcriptional ability

2002 • 21 citations

Differential expression of the murine Ly‐6A/E antigen homolog of human squamous cell carcinoma antigen E48 during malignant transformation and tumor progression of squamous cell carcinoma line Pam 212

1998 • 5 citations