Novel inactivating mutations of transforming growth factor-? type I receptor gene in head-and-neck cancer metastases

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Genetic events and the role of TGFβ in epithelial tumour progression

1999 • 166 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

TbetaR-I(6A) is a candidate tumor susceptibility allele.

1999 • 163 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

1999 • 131 citations

Regulation of growth and differentiation of human keratinocytes by type beta transforming growth factor and epidermal growth factor.

1987 • 124 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

TGF-β and cancer

1999 • 115 citations

Structural alterations of transforming growth factor-? receptor genes in human cervical carcinoma

1999 • 100 citations

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

1998 • 98 citations

Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck

1997 • 85 citations

Biosynthesis of the Type I and Type II TGF-β Receptors

1997 • 83 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

The relationship between sequence and structure in elementary folding units

2000 • 68 citations

Processing of the Transforming Growth Factor β Type I and II Receptors

1997 • 61 citations

TGF‐β1 and skin carcinogenesis: Antiproliferative effect in vitro and TGF‐β1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesis

1991 • 45 citations

High Frequency of Resistance of Human Squamous Carcinoma Cells to the Anti-proliferative Action of Transforming Growth Factor β

1990 • 37 citations

The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma.

1999 • 36 citations

Cloning and Genomic Organization of the Human Transforming Growth Factor-β Type I Receptor Gene

1997 • 34 citations

Transfer of chromosome 18 into human head and neck squamous carcinoma cells: evidence for tumor suppression by Smad4/DPC4.

1997 • 28 citations

Smad Protein Expression and Activation in Transforming Growth Factor-β Refractory Human Squamous Cell Carcinoma Cells

2001 • 24 citations

Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFβRII

2000 • 24 citations

Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.

1998 • 18 citations

Autocrine production of TGF-α and TGF-β during tumour progression of rat oral keratinocytes

1993 • 16 citations

Abnormalities in expression of genes, mRNA, and proteins of transforming growth factor-beta receptor type I and type II in human pituitary adenomas.

1998 • 13 citations

Structural basis of an embryonically lethal single Ala → Thr mutation in the vnd/NK-2 homeodomain

1998 • 12 citations