Liposomes in gene therapy

Intermolecular and Surface Forces

2011 • 17,408 citations

Intermolecular and Surface Forces

2011 • 7,781 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides

1978 • 2,873 citations

Biophysical chemistry

1979 • 1,709 citations

Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope

1964 • 1,653 citations

Polymers at an interface; a simplified view

1987 • 1,606 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Liposomes: From Physics to Applications

1993 • 1,315 citations

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

1994 • 1,306 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Surfactants in Solution

1989 • 1,212 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Spontaneous Vesicle Formation in Aqueous Mixtures of Single-Tailed Surfactants

1989 • 1,138 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

1993 • 888 citations

A novel cationic liposome reagent for efficient transfection of mammalian cells

1991 • 844 citations

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

1987 • 841 citations

Cationic liposome-mediated RNA transfection.

1989 • 804 citations

PHYSICAL CHEMISTRY OF NUCLEIC ACIDS

2002 • 794 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

1993 • 725 citations

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

1989 • 709 citations

Condensation of DNA by multivalent cations: Considerations on mechanism

1991 • 703 citations

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

1995 • 700 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall

1990 • 573 citations

A totally synthetic bilayer membrane

1977 • 556 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Handbook of Lipid Bilayers, Second Edition

1990 • 527 citations

DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

1994 • 496 citations

Mode of formation and structural features of DNA-cationic liposome complexes used for transfection

1993 • 493 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

1993 • 439 citations

A regulatory system for use in gene transfer.

1994 • 434 citations

New structures in complex formation between DNA and cationic liposomes visualized by freeze—fracture electron microscopy

1994 • 425 citations

Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles

1990 • 424 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

1994 • 415 citations

Introduction of liposome-encapsulated SV40 DNA into cells.

1980 • 407 citations

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

1993 • 400 citations

A Transition to a Compact Form of DNA in Polymer Solutions

1971 • 388 citations

Discrete Coil-Globule Transition of Large DNA Induced by Cationic Surfactant

1995 • 351 citations

Characterization of DNA condensates induced by poly(ethylene oxide) and polylysine.

1975 • 345 citations

Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes.

1992 • 334 citations

Immunotherapy of malignancy by in vivo gene transfer into tumors.

1993 • 320 citations

The highly concentrated liquid-crystalline phase of DNA is columnar hexagonal

1989 • 309 citations

Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA

1990 • 297 citations

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.

1990 • 275 citations

Gene Transfer In Vivo with DNA–Liposome Complexes: Safety and Acute Toxicity in Mice

1992 • 266 citations

DNA Bending by Asymmetric Phosphate Neutralization

1994 • 248 citations

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

1995 • 244 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity

1992 • 238 citations

The compaction of DNA helices into either continuous supercoils or folded-fiber rods and toroids

1978 • 233 citations

Gene Transfer In Vivo with DNA–Liposome Complexes: Lack of Autoimmunity and Gonadal Localization

1992 • 222 citations

Gene Transfer with a Series of Lipophilic DNA-Binding Molecules

1994 • 219 citations

Synthetic gene-transfer vectors

1993 • 218 citations

Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells

1989 • 211 citations

The feasibility of targeted selective gene therapy of the hair follicle

1995 • 203 citations

Rapid Communication: In vivo Transfection of Murine Lungs with a Functioning Prokaryotic Gene using a Liposome Vehicle

1989 • 203 citations

Monte Carlo determination of the distribution of ions about a cylindrical polyelectrolyte

1984 • 196 citations

Sterically Stabilized Vesicles

1994 • 191 citations

Fine Mapping of a Mouse Metallothionein Gene Metal Response Element

1989 • 185 citations

In vivo cytokine gene transfer by gene gun reduces tumor growth in mice.

1995 • 184 citations

Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits.

1994 • 179 citations

Macroions in solution and colloidal suspension

1994 • 176 citations

Safety and Short-Term Toxicity of a Novel Cationic Lipid Formulation for Human Gene Therapy

1993 • 171 citations

Bending elasticity of electrically charged bilayers: coupled monolayers, neutral surfaces, and balancing stresses

1992 • 166 citations

Targeted vectors for gene therapy

1995 • 163 citations

Mixed micelles in drug delivery

1992 • 161 citations

Critical conditions for the binding of polyelectrolytes to small oppositely charged micelles

1992 • 156 citations

Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA.

1990 • 154 citations

The origin of the A to B transition in DNA fibers and films

1988 • 148 citations

A molecular dynamics simulation of double-helical B-DNA including counterions and water.

1985 • 145 citations

Parametrization of direct and soft steric-undulatory forces between DNA double helical polyelectrolytes in solutions of several different anions and cations

1994 • 144 citations

Interaction of positively-charged liposomes with blood: implications for their application in vivo

1991 • 144 citations

Decoration of semidilute polymer solutions with surfactant micelles

1987 • 144 citations

Delivery of Recombinant Gene Products with Microencapsulated Cells In Vivo

1993 • 140 citations

Gene transfer and expression. A laboratory manual

1992 • 140 citations

Model nucleohistones: The interaction of F1 and F2al histones with native T7 DNA

1971 • 139 citations

Inhibition of protein kinase C by cationic amphiphiles

1992 • 138 citations

Macroions in Solution and Colloidal Suspension

1992 • 138 citations

Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides

1990 • 137 citations

Conformational Transitions of Mixed Monolayers of Phospholipids and Polyethylene Oxide Lipopolymers and Interaction Forces with Solid Surfaces

1995 • 129 citations

Fine mapping of a mouse metallothionein gene metal response element.

1989 • 126 citations

Structural and functional analysis of cationic transfection lipids: the hydrophobic domain.

1996 • 125 citations

Plasmid DNAs directly injected into mouse brain with lipofectin can be incorporated and expressed by brain cells

1990 • 124 citations

DNA Structure and Recognition

1994 • 118 citations

Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice

1995 • 118 citations

Supramolecular ordering of DNA in the cholesteric liquid crystalline phase: an ultrastructural study

1993 • 118 citations

Immunotherapy of Malignancy by In Vivo Gene Transfer into Tumors

1992 • 117 citations

Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway.

1994 • 113 citations

Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor.

1993 • 113 citations

Liposome stability and formation: Experimental parameters and theories on the size distribution

1993 • 112 citations

Safety and Toxicity of Catheter Gene Delivery to the Pulmonary Vasculature in a Patient with Metastatic Melanoma

1994 • 108 citations

Trefoil Knotting Revealed by Molecular Dynamics Simulations of Supercoiled DNA

1992 • 107 citations

Complex Formation between Polyelectrolyte and Oppositely Charged Mixed Micelles: Static and Dynamic Light Scattering Study of the Effect of Polyelectrolyte Molecular Weight and Concentration

1994 • 106 citations

Liposome toxicity in the mouse central nervous system

1977 • 103 citations

Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct

1992 • 102 citations

A novel gene delivery system using EGF receptor‐mediated endocytosis

1994 • 102 citations

DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants.

1986 • 100 citations

Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes

1993 • 94 citations

Microencapsulation of recombinant cells: a new delivery system for gene therapy

1993 • 86 citations

Gene therapeutics. Methods and applications of direct gene transfer

1996 • 81 citations

Localization and Induced Expression of Fusion Genes in the Rat Lung

1991 • 80 citations

Cloud Feedback: A Stabilizing Effect for the Early Earth?

1982 • 78 citations

Gene therapy for cystic fibrosis in humans by liposome-mediated DNA transfer: the production of resources and the regulatory process.

1994 • 77 citations

A study of the structure of highly concentrated phases of DNA by X-ray diffraction

1992 • 77 citations

Cytolytic activity of liposomes containing stearylamine

1986 • 76 citations

Gene therapy for neurological disorders

1994 • 73 citations

Complex Formation between Polyelectrolyte and Oppositely Charged Mixed Micelles: Soluble Complexes vs Coacervation

1995 • 71 citations

Dendrimers: Dream Molecules Approach Real Applications

1995 • 69 citations

Direct plasmid mediated transfection of adult murine brain cells in vivo using cationic liposomes

1994 • 68 citations

Diaminoalkanes with an odd number of carbon atoms induce compaction of a single double‐stranded DNA chain

1995 • 66 citations

DNA in profile

1991 • 65 citations

The new frontier: gene and oligonucleotide therapy

1994 • 61 citations

Vesicles versus membrane fragments in DODAC suspensions

1990 • 54 citations

A new method for counting labeled nucleic acids by liquid scintillation

1967 • 54 citations

Liposomes as carriers of DNA.

1989 • 53 citations

Liposomes: The Development of a New Carrier System for Introducing Nucleic Acids into Plant and Animal Cells

1982 • 52 citations

Watching molecules crowd: DNA double helices under osmotic stress

1995 • 52 citations

Secondary conformational polymorphism of nucleic acids as a possible functional link between cellular parameters and DNA packaging processes

1991 • 50 citations

Mammalian artificial chromosomes: a new tool for gene therapy.

1994 • 48 citations

Receptor-mediated gene delivery employing lectin-binding specificity.

1994 • 41 citations

The counterion influence on cationic lipid-mediated transfection of plasmid DNA

1996 • 41 citations

Liposomes bearing a quaternary ammonium detergent as an efficient vehicle for functional transfer of TMV-RNA into plant protoplasts

1988 • 39 citations

Ca2+ or Mg2+ nucleotide phosphohydrolases in myometrium: two ecto-enzymes

1991 • 36 citations

Gene Therapy: A Handbook for Physicians

1995 • 34 citations

A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection

1995 • 33 citations

Gene therapeutics: Methods and applications of direct gene transfer

1994 • 31 citations

Correlation between Physicochemical Characteristics of Synthetic Cationic Amphiphiles and Their DNA Transfection Ability

1991 • 29 citations

Stretching of Polyelectrolyte Chains by Oppositely Charged Aggregates

1993 • 28 citations

The Adenovirus Inverted Terminal Repeat Functions as an Enhancer in a Cell-free System

1989 • 22 citations

Targeted delivery of DNA for gene therapy via receptors

1993 • 21 citations

Positive Selectable Markers for Use with Mammalian Cells in Culture

1991 • 20 citations

Cationic Liposomes and DNA Delivery

1993 • 19 citations

Gene Therapy for Neoplastic Diseases

1994 • 17 citations

Theoretical and experimental stabilities of amphiphile vesicles in the presence of sodium chloride

1989 • 14 citations

Does the DLVO account for interactions between closed spheric vesicles?

1992 • 12 citations

Combined Vaccines—The European Contribution

1994 • 12 citations

On the Formation of Inorganic Colloid Particles

1993 • 4 citations