Gene Transfer In Vivo with DNA–Liposome Complexes: Safety and Acute Toxicity in Mice

Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products

1995 • 471 citations

Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery

1997 • 403 citations

Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes

2001 • 363 citations

Cancer Gene Therapy Using Plasmid DNA: Purification of DNA for Human Clinical Trials

1995 • 241 citations

Comprehensive Analysis of the Acute Toxicities Induced by Systemic Administration of Cationic Lipid:Plasmid DNA Complexes in Mice

2000 • 232 citations

Cancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Mice

1995 • 210 citations

In Vivo Delivery to Tumors of DNA Complexed with Linear Polyethylenimine

1999 • 209 citations

Safety and Short-Term Toxicity of a Novel Cationic Lipid Formulation for Human Gene Therapy

1993 • 171 citations

Gene Transfer into Mammalian Cells Using Histone-Condensed Plasmid DNA

1996 • 158 citations

Parenteral Gene Therapy with p53 Inhibits Human Breast TumorsIn VivoThrough a Bystander Mechanism Without Evidence of Toxicity

1997 • 138 citations

A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo

1996 • 122 citations

Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseasesa

1994 • 119 citations

Cancer Gene Therapy Using Plasmid DNA: Safety Evaluation in Rodents and Non-Human Primates

1995 • 110 citations

Plasmid DNA Malaria Vaccine: Tissue Distribution and Safety Studies in Mice and Rabbits

1999 • 106 citations

Immunotherapy for Cancer by Direct Gene Transfer into Tumors. Howard Hughes Medical Institute Research Laboratories, Ann Arbor, Michigan

1994 • 84 citations

Gene Therapy for Head and Neck Cancer

2000 • 60 citations

Cytokine-mediated gene therapy for cancer

1994 • 57 citations

Gene Therapy for Central Nervous System Injury: The Use of Cationic Liposomes: An Invited Review

1997 • 56 citations

Gene Therapy of Human Disease

2002 • 47 citations

Direct gene transfer into the rat pancreas using DNA‐liposomes

1998 • 36 citations

Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization

1999 • 36 citations

Direct Gene Transfer for the Understanding and Treatment of Human Disease

1994 • 25 citations

Epidermis: An Attractive Target Tissue for Gene Therapy.

1994 • 23 citations

Tissue Distribution of the Cytofectin Component of a Plasmid–DNA/Cationic Lipid Complex Following Intravenous Administration in Mice

1997 • 23 citations

Polyplex-mediated gene transfer into human retinal pigment epithelial cells in vitro

2000 • 20 citations

Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA‐liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues

1997 • 19 citations

Lack of toxicity of EGFR antisense gene therapy

2002 • 16 citations

Liposomes and Viruses for Gene Therapy of Cystic Fibrosis

1996 • 16 citations

Locoregional Response and Increased Natural Killer Activity after Intratumoral Injection of HLA-B7/β₂-Microglobulin Gene in Patients with Cancer

1998 • 16 citations

Phase Ia Trial of a Polynucleotide Anti-Tumor Immunization to Human Carcinoembryonic Antigen in Patients with Metastatic Colorectal Cancer. University of Alabama at Birmingham, Birmingham, Alabama

1996 • 15 citations

Local gene delivery to the vessel wall

2001 • 12 citations

Comparative analysis of the uptake and expression of plasmid vectors in human ciliary and retinal pigment epithelial cells in vitro

2001 • 10 citations

DNA vaccines for cancer therapy

1999 • 9 citations

Cardiovascular Gene Therapy: Current Concepts

1996 • 9 citations

Gene Therapy: Molecular Medicine of the 1990s

1994 • 4 citations

Gene Transfer for Therapy and Prophylaxis of HIV‐1 Infection

1993 • 4 citations

Gene Therapy in Cardiovascular Disease

2001 • 4 citations

Vascular Applications of Human Gene Therapy

1995 • 2 citations

In Vivo Gene Transfer: A Potential Approach for Immunotherapy

1995 • 1 citations