Ezrin: A protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.

1993 • 427 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.

1989 • 385 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

1992 • 347 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

A gene family consisting of ezrin, radixin and moesin Its specific localization at actin filament/plasma membrane association sites

1992 • 334 citations

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells

1997 • 317 citations

ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

1997 • 312 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells.

1983 • 294 citations

Glycophorin is linked by band 4.1 protein to the human erythrocyte membrane skeleton

1984 • 283 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

In vitro formation of a complex between cytoskeletal proteins of the human erythrocyte

1979 • 254 citations

cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.

1989 • 253 citations

Moesin: a member of the protein 4.1-talin-ezrin family of proteins.

1991 • 250 citations

PDZ domains bind carboxy-terminal sequences of target proteins

1996 • 244 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization.

1989 • 211 citations

Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1995 • 208 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

Identification of a phosphatidylinositol‐4,5‐bisphosphate‐binding domain in the N‐terminal region of ezrin

1995 • 198 citations

Identification of the Protein 4.1 Binding Interface on Glycophorin C and p55, a Homologue of the Drosophila discs-large Tumor Suppressor Protein

1995 • 197 citations

Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.

1992 • 189 citations

A structural model of human erythrocyte protein 4.1.

1984 • 183 citations

Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1

1994 • 183 citations

The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli.

1991 • 182 citations

The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.

1986 • 173 citations

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes.

1995 • 169 citations

Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton

1997 • 168 citations

In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophorin C.

1994 • 167 citations

Radixin is a novel member of the band 4.1 family.

1991 • 167 citations

Ezrin Becomes Restricted to Outer Cells Following Asymmetrical Division in the Preimplantation Mouse Embryo

1996 • 152 citations

Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons.

1993 • 148 citations

Subcellular Localization of Moesin in Dynamic Filopodia, Retraction Fibers, and Other Structures Involved in Substrate Exploration, Attachment, and Cell-Cell Contacts

1995 • 147 citations

Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis [published erratum appears in J Cell Biol 1991 Sep;114(5):1101-3]

1991 • 147 citations

Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable

1993 • 135 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Ezrin has properties to self-associate at the plasma membrane

1994 • 133 citations

Biochemical Characterization of Ezrin-Actin Interaction

1996 • 125 citations

CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.

1993 • 121 citations

Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivity.

1995 • 120 citations

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.

1996 • 118 citations

The merlin tumor suppressor localizes preferentially in membrane ruffles.

1996 • 116 citations

A Dual Involvement of the Amino-terminal Domain of Ezrin in F- and G-actin Binding

1997 • 112 citations

Polarized distribution of actin isoforms in gastric parietal cells.

1995 • 111 citations

Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.

1995 • 107 citations

Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins.

1993 • 107 citations

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains.

1995 • 106 citations

Ezrin-calpain I interactions in gastric parietal cells

1993 • 96 citations

Interdomain Interactions of Radixin in Vitro

1995 • 93 citations

Cytovillin, a Microvillar Mr 75,000 Protein

1989 • 92 citations

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

1993 • 90 citations

Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains

1995 • 87 citations

Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton.

1996 • 86 citations

Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation

1989 • 80 citations

Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells.

1987 • 80 citations

Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells.

1992 • 77 citations

Single muscle fiber enzyme shifts with hindlimb suspension and immobilization

1989 • 77 citations

Radixin Is a Component of Hepatocyte Microvilli in Situ

1994 • 74 citations

Immunological localization of an 80-kDa phosphoprotein to the apical membrane of gastric parietal cells

1989 • 69 citations

Induction of Tyrosine Phosphorylation and Translocation of Ezrin by Hepatocyte Growth Factor/Scatter Factor (HGF/SF)

1995 • 66 citations

Differential expression of the microspike-associated protein moesin in human tissues.

1995 • 64 citations

Three determinants in ezrin are responsible for cell extension activity.

1997 • 63 citations

Microfilaments and membranes

1993 • 53 citations

Human placental syncytiotrophoblastic Mr 75,000 polypeptide defined by antibodies to a synthetic peptide based on a cloned human endogenous retroviral DNA sequence.

1984 • 50 citations

Cells in culture from rabbit medullary thick ascending limb of Henle's loop

1989 • 46 citations

Ligation of CD4 Surface Antigen Induces Rapid Tyrosine Phosphorylation of the Cytoskeletal Protein Ezrin

1994 • 42 citations

[4] Purification of the intestnal microvillus cytoskeletal proteins villin, fimbrin, and ezrin

1986 • 36 citations

Immunofluorescent and immunochemical evidence for the expression of cytovillin in the microvilli of a wide range of cultured human cells

1988 • 32 citations

Cytovillin and other microvillar proteins of human choriocarcinoma cells

1989 • 28 citations

Redistribution of Mr 75,000 plasma membrane protein, cytovillin, into newly formed microvilli in herpes simplex and Semliki Forest virus infected human embryonal fibroblasts.

1988 • 27 citations

CD44 in human placenta: Localization and binding to hyaluronic acid

1993 • 23 citations

Characterization of a chemically homogeneous tumor antigen from a methylcholanthrene-induced sarcoma, Meth A

1986 • 17 citations

Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B

1995 • 14 citations

Regulation Mechanism of ERM Protein/Plasma Membrane Association : Possible Involvement of Phosphatidylinositol Turnover and Rho-dependent Signaling Pathway

1996 • 13 citations