Impaired Transition State Complementarity in the Hydrolysis of O-Arylphosphorothioates by Protein-Tyrosine Phosphatases

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

Enzyme Mechanism from Isotope Effects

1991 • 574 citations

Transition States of Biochemical Processes

1978 • 418 citations

Acid Ionization Constants of Alcohols. II. Acidities of Some Substituted Methanols and Related Compounds^1,2

1960 • 411 citations

alpha-Chymotrypsin: Enzyme concentration and kinetics

1967 • 175 citations

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction

1995 • 134 citations

The effect of divalent metal ions on the rate and transition-state structure of phosphoryl-transfer reactions

1987 • 133 citations

Mechanisms of phosphoryl and acyl transfer.

1995 • 122 citations

Calculation of the pKa values of alcohols from .sigma. constants and from the carbonyl frequencies of their esters

1971 • 118 citations

Reactions of pyridines and primary amines with N-phosphorylated pyridines

1984 • 104 citations

Walden-Inversion-Enforced Transition-State Stabilization in a Protein Tyrosine Phosphatase

1998 • 99 citations

Mechanisms of Hydrolysis of O-Phosphorothioates and Inorganic Thiophosphate by Escherichia coli Alkaline Phosphatase

1974 • 71 citations

Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase-Catalyzed Reaction. A Pre-Steady-State and Steady-State Kinetic Investigation

1996 • 70 citations

Reactivity of Alcohols Toward the Phosphoenzyme Intermediate in the Protein-Tyrosine Phosphatase-Catalyzed Reaction: Probing the Transition State of the Dephosphorylation Step

1996 • 58 citations

Pyrophosphate formation for acetyl phosphate and orthophosphate anions in concentrated aqueous salt solutions does not provide evidence for a metaphosphate intermediate

1986 • 56 citations

Comparisons of Phosphorothioate and Phosphate Monoester Transfer Reactions: Activation Parameters, Solvent Effects, and the Effect of Metal Ions

1999 • 50 citations

Examination of the Transition State of the Low-Molecular Mass Small Tyrosine Phosphatase 1. Comparisons with Other Protein Phosphatases

1997 • 47 citations

Evidence for free monomeric thiometaphosphate anion in aqueous solution

1988 • 32 citations

Stereoelectronic effects in the hydrolysis of bicyclic and acyclic phosphates and phosphorothionates

1986 • 31 citations

Thiophosphorylated Substrate Analogs Are Potent Active Site-Directed Inhibitors of Protein-Tyrosine Phosphatases

1994 • 26 citations

Protein-tyrosine-phosphatase

1991 • 16 citations