Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

1999 • 902 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

1998 • 800 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

1997 • 569 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

1995 • 488 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Apolipoprotein E ∈4 Associated With Chronic Traumatic Brain Injury in Boxing

1997 • 414 citations

Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

1995 • 403 citations

Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

1999 • 378 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

1999 • 310 citations

Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein

1992 • 289 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations 11The members of the Neurologic Outcome Research Group of the Duke Heart Center are listed in Appendix A.

1997 • 264 citations

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease

1995 • 242 citations

Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

2000 • 238 citations

Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

1996 • 226 citations

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

2000 • 220 citations

Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.

1995 • 211 citations

The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant

1996 • 206 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice

1996 • 178 citations

Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons

1999 • 172 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Lower Cognitive Performance in Normal Older Adult Male Twins Carrying the Apolipoprotein E 4 Allele

1994 • 144 citations

Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age

1990 • 143 citations

High Frequency of Apolipoprotein E ϵ4 Allele in Young Individuals with Very Mild Alzheimer's Disease-Related Neurofibrillary Changes

1998 • 132 citations

Normal and Pathological Tau Proteins as Factors for Microtubule Assembly

1997 • 128 citations

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

1998 • 124 citations

Aβ‐peptide length aid apolipoprotein E genotype in Alzheimer's disease

1996 • 119 citations

Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated

1997 • 117 citations

Association of apolipoprotein E ∈4 allele with bulbar-onset motor neuron disease

1996 • 110 citations

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

1996 • 100 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis

1996 • 87 citations

Effect of Apolipoprotein E on Neurite Outgrowth and β‐Amyloid‐Induced Toxicity in Developing Rat Primary Hippocampal Cultures

1997 • 80 citations

Apolipoprotein E genotype in diverse neurodegenerative disorders

1995 • 76 citations

Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age

1992 • 72 citations

Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity

1995 • 58 citations

Neurite Degeneration Elicited by Apolipoprotein E Peptides

1994 • 50 citations

Regionally specific neuronal expression of human APOE gene in transgenic mice

1998 • 48 citations

Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice

1998 • 43 citations

ApoE Synthesis in Human Neuroblastoma Cells

1997 • 42 citations

Accumulation of SNAP-25 immunoreactive material in axons of Alzheimerʼs disease

1997 • 35 citations

Analysis of a Novel Mechanism of Neuronal Toxicity Produced by an Apolipoprotein E‐Derived Peptide

1999 • 34 citations

A Test of the Cytosolic Apolipoprotein E Hypothesis Fails to Detect the Escape of Apolipoprotein E from the Endocytic Pathway into the Cytosol and Shows that Direct Expression of Apolipoprotein E in the Cytosol is Cytotoxic

1999 • 30 citations

Involvement of clathrin light chains in the pathology of Alzheimer's disease

1994 • 28 citations

Cis-Acting Human ApoE Tissue Expression Element is Associated with Human Pattern of Intraneuronal ApoE in Transgenic Mice

1998 • 21 citations

Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE

1999 • 20 citations

Lack of association of apolipoprotein E ϵ4 allele with bulbar‐onset motor neuron disease

1997 • 19 citations

Intraneuronal ApoE in Human Visual Cortical Areas Reflects the Staging of Alzheimer Disease Pathology

1998 • 16 citations

Apolipoprotein E allele frequencies in sporadic inclusion body myositis

1996 • 12 citations