ApoE Synthesis in Human Neuroblastoma Cells

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

1981 • 568 citations

Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns

1987 • 503 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

1994 • 445 citations

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 • 420 citations

Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo

1984 • 407 citations

The apolipoprotein ε4 allele in patients with Alzheimer's disease

1993 • 401 citations

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

[Apolipoprotein E polymorphism and Alzheimer disease].

1996 • 302 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.

1977 • 233 citations

Inside SWISS‐2DPAGE database

1995 • 229 citations

Molecular cloning and primary structure of human glial fibrillary acidic protein.

1989 • 206 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

1984 • 188 citations

Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice

1996 • 178 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Gene dose of the ε4 allele of apolipoprotein E and disease progression in sporadic late‐onset alzheimer's disease

1995 • 148 citations

A Specific 37,000-Dalton Protein That Accumulates in Regenerating but Not in Nonregenerating Mammalian Nerves

1985 • 144 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

Differential Binding of Apolipoprotein E Isoforms to Tau and Other Cytoskeletal Proteins

1996 • 82 citations

Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.

1977 • 75 citations

Apolipoprotein E Interaction with the Neurofibrillary Tangles and Senile Plaques in Alzheimer Disease: Implications for Disease Pathogenesis

1995 • 73 citations

Two‐Dimensional Characterization of Paired Helical Filament‐Tau from Alzheimer's Disease: Demonstration of an Additional 74‐kDa Component and Age‐Related Biochemical Modifications

1997 • 72 citations

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

1995 • 56 citations

Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease

1995 • 53 citations

Enzymatic activites during differentiation of the human neuroblastoma cells, LA‐N‐1 and LA‐N‐2

1990 • 50 citations

Relevance of the quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer's disease

1996 • 47 citations

Expression of ApoE Gene in Chinese Hamster Cells with a Reversible Defect in O-Glycosylation

1989 • 45 citations

Retinoic Acid‐Induced Differentiation of Human Neuroblastoma SH‐SY5Y Cells Is Associated with Changes in the Abundance of G Proteins

1994 • 45 citations

Neuronal and vascular pathology produced by verocytotoxin 2 in the rabbit central nervous system

1996 • 39 citations

Shift from fetal‐type to Alzheimer‐type phosphorylated Tau proteins in SKNSH‐SY 5Y cells treated with okadaic acid

1995 • 36 citations

Characterization of a Monoclonal Antibody that Binds to Apolipoprotein E and to Lipoprotein of Human Plasma Containing APO E. Applications to ELISA Quantification of Plasma APO E

1988 • 29 citations

Evidence for apolipoprotein E ϵ4 association in early‐onset Alzheimer's patients with late‐onset relatives

1995 • 27 citations

Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/ parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes

1996 • 27 citations

An Enzyme-Linked Immunosorbent Assay Method to Measure Human Apolipoprotein E Levels Using Commercially Available Reagents: Effect of Apolipoprotein E Polymorphism on Serum Apolipoprotein E Concentration

1994 • 20 citations

Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor

1994 • 13 citations

Pattern of Apolipoprotein E Immunoreactivity During Brain Aging

1996 • 13 citations

Transient expression of apolipoprotein-E in neonates with pontosubicular neuron necrosis

1996 • 11 citations

Apolipoprotein E and Alzheimer’s disease

1995 • 7 citations

[Normal cerebral aging: study of glial reaction].

1994 • 6 citations

Deleted Work

1955 • 0 citations