A Test of the Cytosolic Apolipoprotein E Hypothesis Fails to Detect the Escape of Apolipoprotein E from the Endocytic Pathway into the Cytosol and Shows that Direct Expression of Apolipoprotein E in the Cytosol is Cytotoxic

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1987 • 666 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

How proteins enter the nucleus

1991 • 555 citations

Isoform-specific binding of apolipoprotein E to beta-amyloid.

1994 • 529 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

1994 • 427 citations

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

1982 • 420 citations

Human Apolipoprotein E Receptor 2

1996 • 378 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

1995 • 337 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells.

1986 • 253 citations

Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I.

1990 • 243 citations

Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro

1997 • 237 citations

Apolipoprotein E synthesis in human kidney, adrenal gland, and liver.

1983 • 224 citations

The effect of protein context on nuclear location signal function

1987 • 214 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

Lipoprotein Uptake by Neuronal Growth Cones in Vitro

1987 • 209 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid

1995 • 184 citations

Cloning and Sequencing of Human gp330, a Ca²⁺‐Binding Receptor with Potential Intracellular Signaling Properties

1996 • 151 citations

Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates.

1985 • 147 citations

Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans

1998 • 134 citations

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

1998 • 124 citations

Expression of apolipoprotein E mRNA in rat microglia

1996 • 122 citations

[7] Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor

1986 • 106 citations

Apolipoprotein E synthesis in peripheral tissues of nonhuman primates.

1985 • 106 citations

Plasma Lipopolysaccharide-binding Protein Is Found Associated with a Particle Containing Apolipoprotein A-I, Phospholipid, and Factor H-related Proteins

1996 • 100 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages.

1991 • 78 citations

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor

1994 • 76 citations

Induction of rat E and chicken A-I apolipoproteins and mRNAs during optic nerve degeneration.

1986 • 69 citations

Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism

1997 • 66 citations

Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology

1995 • 59 citations

Hepatic expression of genes regulating lipid metabolism in rabbits.

1993 • 42 citations

The intracellular fate of apolipoprotein E is tau dependent and apoe allelespecific

1996 • 35 citations