Recognition and clearance of apoptotic cells: a role for complement and pentraxins

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Consequences of Cell Death

2000 • 1,382 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Identification of a factor that links apoptotic cells to phagocytes

2002 • 1,323 citations

Phagocytosis and clearance of apoptotic cells is mediated by MER

2001 • 1,153 citations

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

2001 • 1,122 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 1,090 citations

The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

1994 • 1,030 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 897 citations

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

2000 • 733 citations

Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

1998 • 692 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages

2002 • 682 citations

C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

2000 • 681 citations

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.

1997 • 661 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity

2001 • 560 citations

Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex

2002 • 506 citations

Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

1999 • 491 citations

Collectins: collagenous C-type lectins of the innate immune defense system

1994 • 461 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 427 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.

1992 • 420 citations

Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells

2001 • 407 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 394 citations

The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II

1999 • 382 citations

Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3

1997 • 378 citations

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

2002 • 375 citations

Biochemical and functional characterization of the interaction between pentraxin 3 and C1q

2003 • 329 citations

Structure and function of the pentraxins

1995 • 327 citations

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

2002 • 313 citations

The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells

2000 • 306 citations

Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 • 306 citations

I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation

2002 • 288 citations

Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.

1996 • 270 citations

Processing of engulfed apoptotic bodies yields T cell epitopes.

1997 • 267 citations

The Globular Heads of C1q Specifically Recognize Surface Blebs of Apoptotic Vascular Endothelial Cells

2001 • 262 citations

cDNA Cloning and Primary Structure Analysis of C1qRP, the Human C1q/MBL/SPA Receptor That Mediates Enhanced Phagocytosis In Vitro

1997 • 252 citations

Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies

2000 • 243 citations

Hereditary C1q deficiency and systemic lupus erythematosus

1994 • 213 citations

GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1992 • 210 citations

Surfactant Protein A Enhances Alveolar Macrophage Phagocytosis of Apoptotic Neutrophils

2001 • 209 citations

C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific

2000 • 206 citations

Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan.

1984 • 205 citations

Apoptotic cell clearance in systemic lupus erythematosus: I. Opsonization by antiphospholipid antibodies

1998 • 203 citations

Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q.

1993 • 167 citations

Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death

2001 • 159 citations

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

1996 • 158 citations

Serum Amyloid P Component Binds to Fcγ Receptors and Opsonizes Particles for Phagocytosis

2001 • 157 citations

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages.

1997 • 150 citations

Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion.

1997 • 131 citations

Serum Amyloid P Component and C-Reactive Protein Opsonize Apoptotic Cells for Phagocytosis through Fcγ Receptors

2002 • 129 citations

Chromatin-Independent Binding of Serum Amyloid P Component to Apoptotic Cells

2001 • 119 citations

Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: Mechanism for removal of apoptotic cells in the inflamed nervous system

2001 • 116 citations

Human C1qRp Is Identical with CD93 and the mNI-11 Antigen But Does Not Bind C1q

2002 • 114 citations

Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q.

1991 • 112 citations

Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells

2002 • 101 citations

Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti-?2-glycoprotein I antibodies

1999 • 90 citations

Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells

1999 • 86 citations

AN APPETITE FOR APOPTOTIC CELLS? CONTROVERSIES AND CHALLENGES

2000 • 66 citations

Increased Cell Surface Exposure of Fucose Residues Is a Late Event in Apoptosis

1998 • 45 citations

Lack of specific receptors for C-reactive protein on white blood cells

2001 • 42 citations

Expression of membrane C1q in human monocyte‐derived macrophages is developmentally regulated and enhanced by interferon‐γ

2001 • 37 citations

Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface

2002 • 33 citations