The Structure and Biological Features of Fibrinogen and Fibrin

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

On the Regulation and Control of Fibrinolysis

1980 • 1,139 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

Human platelets possess an inducible and saturable receptor specific for fibrinogen.

1979 • 713 citations

Cross-linking of cold-insoluble globulin by fibrin-stabilizing factor

1975 • 572 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

A two-step fibrinogen–fibrin transition in blood coagulation

1978 • 472 citations

Lipoprotein(a), fibrin binding, and plasminogen activation.

1990 • 460 citations

A player of many parts: The spotlight falls on thrombin's structure

1993 • 444 citations

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin

1997 • 392 citations

Studies on the kinetics of plasminogen activation by tissue plasminogen activator

1982 • 340 citations

Interactions among Heparin, Cold-Insoluble Globulin, and Fibrinogen in Formation of the Heparin-Precipitable Fraction of Plasma

1977 • 324 citations

γ-γ Cross-linking sites in human and bovine fibrin

1971 • 300 citations

Subunit Structure of Human Fibrinogen, Soluble Fibrin, and Cross-Linked Insoluble Fibrin

1970 • 287 citations

Significance of Cross-Linking of α2-Plasmin Inhibitor to Fibrin in Inhibition of Fibrinolysis and in Hemostasis

1982 • 287 citations

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin.

1989 • 286 citations

Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers

1978 • 278 citations

Initial plasmin-degradation of fibrin as the basis of a positive feed-back mechanism in fibrinolysis

1984 • 271 citations

Fibrin in human plasma: Gel architectures governed by rate and nature of fibrinogen activation

1994 • 266 citations

COVALENT STRUCTURE OF FIBRINOGEN

1983 • 259 citations

Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex.

1983 • 250 citations

Carboxyl-terminal portions of the alpha chains of fibrinogen and fibrin. Localization by electron microscopy and the effects of isolated alpha C fragments on polymerization

1993 • 248 citations

Binding of Basic Fibroblast Growth Factor to Fibrinogen and Fibrin

1998 • 234 citations

The binding of thrombin by fibrin.

1979 • 223 citations

The Fibrinogen-Fibrin Conversion

1957 • 223 citations

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.

1987 • 222 citations

Crystal structure of a 30 kDa C-terminal fragment from the γ chain of human fibrinogen

1997 • 211 citations

The Preparation and Properties of Human Fibrinogen of Relatively High Solubility^*

1966 • 207 citations

Human Fibrinogen Heterogeneities

1972 • 203 citations

The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion.

1993 • 190 citations

.gamma. and .gamma.' chains of human fibrinogen are produced by alternative mRNA processing

1984 • 172 citations

Fibrinogen Is a Ligand for Integrin α5β1 on Endothelial Cells

1997 • 172 citations

Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins

1987 • 168 citations

Role of the .alpha.C Domains of Fibrin in Clot Formation

1994 • 168 citations

Identification and mass analysis of human fibrinogen molecules and their domains by scanning transmission electron microscopy

1981 • 162 citations

Anion-binding exosite of human .alpha.-thrombin and fibrin(ogen) recognition

1988 • 161 citations

The primary fibrin polymerization pocket: Three-dimensional structure of a 30-kDa C-terminal γ chain fragment complexed with the peptide Gly-Pro-Arg-Pro

1997 • 157 citations

Crystal Structure of Fragment Double-D from Human Fibrin with Two Different Bound Ligands^,

1998 • 157 citations

Amino Acid Sequences in Fibrinogen Mediating Its Interaction with Its Platelet Receptor, GPIIbIIIa

1989 • 145 citations

Human Fibroblasts Bind Directly to Fibrinogen at RGD Sites through Integrin αvβ3

1997 • 143 citations

Plasma Factor XIII Binds Specifically to Fibrinogen Molecules Containing γ‘ Chains

1996 • 142 citations

Fibrin II induces endothelial cell capillary tube formation.

1995 • 137 citations

Structure of the fibrin protofibril.

1981 • 137 citations

Identification and Characterization of the Thrombin Binding Sites on Fibrin

1996 • 133 citations

The Mechanism of Polymerization of Fibrinogen

1952 • 132 citations

Tissue plasminogen activator and urokinase mediate the binding of Glu-plasminogen to plasma fibrin I. Evidence for new binding sites in plasmin-degraded fibrin I.

1985 • 131 citations

Interaction of histidine-rich glycoprotein with fibrinogen and fibrin.

1986 • 128 citations

Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.

1986 • 124 citations

Amino acid sequence of the factor XIII_a acceptor site in bovine plasma fibronectin

1981 • 123 citations

Conversion of Fibrinogen to Fibrin: Mechanism of Exposure of tPA- and Plasminogen-Binding Sites

2000 • 119 citations

Endothelial Cell VE-cadherin Functions as a Receptor for the β15–42 Sequence of Fibrin

1998 • 116 citations

Cross-linking of fibrinogen and fibrin by fibrin-stablizing factor (factor XIIIa).

1975 • 116 citations

Note on the Adsorption of Thrombin on Fibrin

1945 • 112 citations

An electron microscopic investigation of the polymerization of bovine fibrin monomer

1972 • 111 citations

Insulin-like Growth Factor-binding Protein-3 Binds Fibrinogen and Fibrin

1999 • 105 citations

Carboxy-terminal amino acid sequence of a human fibrinogen .gamma.-chain variant (.gamma.')

1981 • 104 citations

Recognition site for the platelet receptor is present on the 15-residue carboxy-terminal fragment of the γ chain of human fibrinogen and is not involved in the fibrin polymerization reaction

1983 • 100 citations

Cross-linking of α2-plasmin inhibitor and fibronectin to fibrin by fibrin-stabilizing factor

1981 • 96 citations

An Antithrombin Reaction Related to Prothrombin Activation

1953 • 95 citations

Identification and Characterization of Novel tPA- and Plasminogen-Binding Sites within Fibrin(ogen) αC-Domains

2000 • 87 citations

Cell proliferation on fibrin: modulation by fibrinopeptide cleavage

1995 • 86 citations

Embolized ischemic lesions of toes in an afibrinogenemic patient: possible relevance to in vivo circulating thrombin

2001 • 85 citations

The Amino Acid Sequence in Fibrin Responsible for High Affinity Thrombin Binding

2001 • 85 citations

Identification of the α Chain Lysine Donor Sites Involved in Factor XIIIa Fibrin Cross-linking

1996 • 83 citations

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.

1992 • 83 citations

Quantitative characterization of the binding of plasminogen to intact fibrin clots, lysine-Sepharose, and fibrin cleaved by plasmin

1985 • 83 citations

Identification of covalently linked trimeric and tetrameric D domains in crosslinked fibrin.

1989 • 82 citations

Disulfide bridges in NH2-terminal part of human fibrinogen

1976 • 82 citations

Potentiation of Endothelial Cell Proliferation by Fibrin(ogen)-bound Fibroblast Growth Factor-2

1999 • 81 citations

Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation

1983 • 81 citations

Hybrid fibrin: proof of the intermolecular nature of γ-γ crosslinking units

1971 • 81 citations

FIBRINOPEPTIDE B IN FIBRIN ASSEMBLY AND METABOLISM: PHYSIOLOGIC SIGNIFICANCE IN DELAYED RELEASE OF THE PEPTIDE*

1983 • 80 citations

Dysfibrinogenemia and Thrombosis

1999 • 79 citations

Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain

1996 • 78 citations

Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.

1985 • 77 citations

Monocyte Plasminogen Activator Inhibitor 2 (PAI-2) Inhibits u-PA-mediated Fibrin Clot Lysis and Is Cross-linked to Fibrin

1999 • 77 citations

The Covalent Structure of Factor XIIIa Crosslinked Fibrinogen Fibrils

1995 • 75 citations

Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.

1992 • 74 citations

Studies on the ultrastructure of fibrin lacking fibrinopeptide B (beta- fibrin)

1987 • 74 citations

Evidence for a second type of fibril branch point in fibrin polymer networks, the trimolecular junction

1993 • 73 citations

Cross-linking of Plasminogen Activator Inhibitor 2 and α2-Antiplasmin to Fibrin(ogen)

2000 • 72 citations

The role of fibrinogen D domain intermolecular association sites in the polymerization of fibrin and fibrinogen Tokyo II (gamma 275 Arg-->Cys).

1995 • 71 citations

Factor XIIIa-Catalyzed Cross-Linking of Recombinant αC Fragments of Human Fibrinogen

1996 • 67 citations

Immunoelectrophoretic characterizations of the cross-linking of fibrinogen and fibrin by factor XIIIa and tissue transglutaminase. Identification of a rapid mode of hybrid alpha-/gamma-chain cross-linking that is promoted by the gamma-chain cross-linking.

1991 • 66 citations

Localization of the binding site on fibrin for the secondary binding site of thrombin

1988 • 64 citations

Cross-Linked Fibrinogen Dimers Demonstrate a Feature of the Molecular Packing in Fibrin Fibers

1981 • 63 citations

Heparin-Binding Domain of Fibrin Mediates Its Binding to Endothelial Cells

1996 • 59 citations

Fibrinogen and Fibrin Protect Fibroblast Growth Factor-2 from Proteolytic Degradation

2000 • 57 citations

Identification of B beta chain domains involved in human fibrinogen assembly.

1992 • 56 citations

The polymerization and thrombin-binding properties of des-(B beta 1-42)-fibrin.

1990 • 56 citations

Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots.

1987 • 56 citations

BIOCHEMICAL AND CHROMATOGRAPHIC STUDIES OF CERTAIN ACTIVITIES ASSOCIATED WITH HUMAN FIBRINOGEN PREPARATIONS*

1963 • 54 citations

Photoaffinity labeling of the primary fibrin polymerization site: isolation and characterization of a labeled cyanogen bromide fragment corresponding to gamma-chain residues 337-379.

1992 • 52 citations

The sequence gamma-(312-324) is a fibrin-specific epitope

1991 • 52 citations

Conservation of human fibrinogen conformation after cleavage of the B beta chain NH2 terminus.

1985 • 51 citations

Multiple Binding with Identical Linkage: A Mechanism That Explains the Effect of Lipoprotein(a) on Fibrinolysis

1995 • 51 citations

A Novel Degradation Pathway of Tissue Factor Pathway Inhibitor: Incorporation Into Fibrin Clot and Degradation by Thrombin

1997 • 50 citations

The Role of Amino-Terminal Disulfide Bonds in the Structure and Assembly of Human Fibrinogen

1993 • 49 citations

Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments.

1993 • 46 citations

Characterization of the gamma chain platelet binding site on fibrinogen fragment D

1992 • 44 citations

Location of the binding site “b” for lateral polymerization of fibrin

1990 • 44 citations

Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain.

1989 • 43 citations

Coexisting dysfibrinogenemia (gammaR275C) and factor V Leiden deficiency associated with thromboembolic disease (fibrinogen Cedar Rapids).

2000 • 42 citations

Strategy for Recombinant Multichain Protein Synthesis: Fibrinogen Bβ-Chain Variants as Thrombin Substrates

1996 • 41 citations

Factor XIIIa Cross-links Lipoprotein(a) With Fibrinogen and Is Present in Human Atherosclerotic Lesions

1998 • 37 citations

Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42

1993 • 36 citations

Fibroblasts Spread on Immobilized Fibrin Monomer by Mobilizing a β1-class Integrin, Together with a Vitronectin Receptor αvβ3 on Their Surface

1997 • 35 citations

MORPHOLOGY OF FIBRINOGEN MONOMERS AND OF FIBRIN PROTOFIBRILS*

1983 • 34 citations

FIBRINOGEN HETEROGENEITY*

1983 • 32 citations

Fibrinogen Naples I (Bβ A68T) Nonsubstrate Thrombin-Binding Capacities

2001 • 31 citations

Characterization of the gamma chain platelet binding site on fibrinogen fragment D

1992 • 30 citations

Evidence for Intramolecular Cross-Linked Aα·γ Chain Heterodimers in Plasma Fibrinogen

1996 • 30 citations

Distinctive role of histidine-16 of the B beta chain of fibrinogen in the end-to-end association of fibrin.

1986 • 29 citations

A synthetic analog of fibrinogen alpha 27-50 is an inhibitor of thrombin.

1991 • 29 citations

High levels of histidine-rich glycoprotein and thrombotic diathesis. Report of two unrelated families

1993 • 28 citations

Cross-Linking of Fibronectin to C-Terminal Fragments of the Fibrinogen α-Chain by Factor XIIIa

1997 • 28 citations

Isolation and Characterization of the Fibrin Intermediate Arising from Cleavage of One Fibrinopeptide A from Fibrinogen

1996 • 28 citations

Evaluation of the factors contributing to fibrin-dependent plasminogen activation.

1998 • 28 citations

Contact with the N Termini in the Central E Domain Enhances the Reactivities of the Distal D Domains of Fibrin to Factor XIIIa

1995 • 27 citations

Localization of a fibrin polymerization site complementary to Gly‐His‐Arg sequence

1993 • 27 citations

The complementary aggregation sites of fibrin investigated through examination of polymers of fibrinogen with fragment E

1998 • 26 citations

Electron microscope structural study of modified fibrin and a related modified fibrinogen aggregate

1983 • 26 citations

Endothelial cell responses to fibrin mediated by FPB cleavage and the amino terminus of the beta chain.

1993 • 25 citations

Familial association of high levels of histidine-rich glycoprotein and plasminogen activator inhibitor-1 with venous thromboembolism.

1993 • 25 citations

A New Case of Hereditary Histidine-rich Glycoprotein Deficiency with Familial Thrombophilia

1996 • 24 citations

Congenital Histidine-Rich Glycoprotein Deficiency

1993 • 24 citations

A Synthetic Analog of Fibrinogen α27–50 Is an Inhibitor of Thrombin

1991 • 24 citations

Evaluation of the Factors Contributing to Fibrin–dependent Plasminogen Activation

1998 • 23 citations

Plasminogen binding by α2-antiplasmin and histidine-rich glycoprotein does not inhibit plasmiogen activation at the surface of fibrin

1992 • 23 citations

Factors affecting .gamma.-chain multimer formation in crosslinked fibrin

1992 • 22 citations

A role for platelets and thrombin in the juvenile stroke of two siblings with defective thrombin-adsorbing capacity of fibrin(ogen).

1991 • 20 citations

Chromatography and electron microscopy of cross‐linked fibrin polymers—a new model describing the cross‐linking at the DD‐trans contact of the fibrin molecules

1988 • 18 citations

Characterization of the Binding of Factor Xa to Fibrinogen/Fibrin Derivatives and Localization of the Factor Xa Binding Site on Fibrinogen

1995 • 18 citations

The sequence A??-(154 ??? 159) of fibrinogen is capable of accelerating the t-PA catalysed activation of plasminogen

1991 • 17 citations

The location of the carboxy-terminal region of γ chains in fibrinogen and fibrin D domains

1998 • 17 citations

Sequence of release of fibrinopeptide A from fibrinogen molecules by thrombin or Atroxin.

1995 • 16 citations

Orientation of the carboxy-terminal regions of fibrin gamma chain dimers determined from the crosslinked products formed in mixtures of fibrin, fragment D, and factor XIIIa.

1995 • 14 citations

Crosslinking of fibrinogen to immobilized DesAA-fibrin

1985 • 14 citations

Orientation of the Carboxy-terminal Regions of Fibrin γ Chain Dimers Determined from the Crosslinked Products Formed in Mixtures of Fibrin, Fragment D, and Factor XIIIa

1995 • 13 citations

Position of γ-Chain Carboxy-Terminal Regions in Fibrinogen/Fibrin Cross-Linking Mixtures

2000 • 11 citations

Twofold Symmetry of Human Fibrinogen Proved at the β Chain Distal Domains by Monoclonal−Immunoelectron Microscopy and Image Analysis

1996 • 8 citations

Fibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis

1986 • 5 citations

Deleted Work

1955 • 0 citations