Glutamatergic mechanisms in addiction

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Predictive Reward Signal of Dopamine Neurons

1998 • 4,446 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 2,110 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Limbic Activation During Cue-Induced Cocaine Craving

1999 • 1,518 citations

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

2000 • 1,334 citations

Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

1998 • 1,247 citations

A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants

1997 • 1,234 citations

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

2001 • 1,084 citations

Neurobiology of addiction

1996 • 1,082 citations

The dopamine hypothesis of reward: past and current status

1999 • 981 citations

Activation of memory circuits during cue-elicited cocaine craving.

1996 • 939 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

Cue-Induced Cocaine Craving: Neuroanatomical Specificity for Drug Users and Drug Stimuli

2000 • 919 citations

The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior

2001 • 905 citations

The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods

1982 • 884 citations

Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

1987 • 857 citations

Building Neural Representations of Habits

1999 • 842 citations

The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data

1994 • 807 citations

Neuronal activity in monkey ventral striatum related to the expectation of reward

1992 • 755 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Progress in Brain Research

1964 • 672 citations

Pathophysiological Basis of Vulnerability to Drug Abuse: Role of an Interaction Between Stress, Glucocorticoids, and Dopaminergic Neurons

1996 • 671 citations

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

2001 • 622 citations

Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization

1996 • 609 citations

Drug addiction: bad habits add up

1999 • 592 citations

Tolerance and sensitization to the behavioral effects of drugs

1993 • 589 citations

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

2001 • 548 citations

Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction

2000 • 545 citations

Neural Activity Related to Drug Craving in Cocaine Addiction

2001 • 545 citations

The basolateral amygdala-ventral striatal system and conditioned place preference: Further evidence of limbic-striatal interactions underlying reward-related processes

1991 • 507 citations

Neuroadaptations involved in amphetamine and cocaine addiction

1998 • 506 citations

Pharmacology and behavioral pharmacology of the mesocortical dopamine system

2001 • 478 citations

Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents

1996 • 454 citations

Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats

2000 • 446 citations

Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving

1998 • 442 citations

Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

2000 • 412 citations

Functional Magnetic Resonance Imaging of Cocaine Craving

2001 • 411 citations

Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens

1998 • 382 citations

Cellular Mechanisms of Infralimbic and Prelimbic Prefrontal Cortical Inhibition and Dopaminergic Modulation of Basolateral Amygdala NeuronsIn Vivo

2002 • 380 citations

Regional brain metabolic activation during craving elicited by recall of previous drug experiences

1999 • 348 citations

Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA

1987 • 339 citations

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine

1997 • 338 citations

Dopamine Attenuates Prefrontal Cortical Suppression of Sensory Inputs to the Basolateral Amygdala of Rats

2001 • 338 citations

From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat

1995 • 336 citations

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

1996 • 331 citations

Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization

1998 • 327 citations

Coincident Activation of NMDA and Dopamine D₁Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning

2000 • 324 citations

Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens

2002 • 303 citations

Response-reinforcement learning is dependent on N -methyl- <scp>d</scp> -aspartate receptor activation in the nucleus accumbens core

1997 • 295 citations

Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors

2000 • 294 citations

Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.

1995 • 291 citations

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

2001 • 287 citations

Time-Dependent Changes in Cocaine-Seeking Behavior and Extracellular Dopamine Levels in the Amygdala during Cocaine Withdrawal

1998 • 279 citations

Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning.

1996 • 275 citations

Network-Level Changes in Expression of Inducible Fos–Jun Proteins in the Striatum during Chronic Cocaine Treatment and Withdrawal

1996 • 274 citations

Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro

1996 • 260 citations

A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior

1999 • 250 citations

Modulation of Hippocampal and Amygdalar-Evoked Activity of Nucleus Accumbens Neurons by Dopamine: Cellular Mechanisms of Input Selection

2001 • 244 citations

Repeated Cocaine Alters Glutamate Receptor Subunit Levels in the Nucleus Accumbens and Ventral Tegmental Area of Rats that Develop Behavioral Sensitization

1999 • 241 citations

Modulation of Basolateral Amygdala Neuronal Firing and Afferent Drive by Dopamine Receptor ActivationIn Vivo

1999 • 230 citations

NMDA receptors as targets for drug action in neuropathic pain

2001 • 229 citations

Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior

2001 • 218 citations

Functional Relationship Among Medial Prefrontal Cortex, Nucleus Accumbens, and Ventral Tegmental Area in Locomotion and Reward

2000 • 215 citations

Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons

1998 • 215 citations

Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse

2000 • 213 citations

Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning.

1996 • 211 citations

Stimulation of the Ventral Subiculum of the Hippocampus Evokes Glutamate Receptor‐mediated Changes in Dopamine Efflux in the Rat Nucleus Accumbens

1997 • 211 citations

Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine

1997 • 210 citations

Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors.

1997 • 210 citations

Mnemonic functions of the basal ganglia

1997 • 207 citations

NMDA receptor antagonists as analgesics: focus on the NR2B subtype

2001 • 204 citations

Chemical Stimulation of the Ventral Hippocampus Elevates Nucleus Accumbens Dopamine by Activating Dopaminergic Neurons of the Ventral Tegmental Area

2000 • 194 citations

The role of contextual versus discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine

2000 • 187 citations

Repeated Cocaine Administration Alters Extracellular Glutamate in the Ventral Tegmental Area

1998 • 186 citations

Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release

1996 • 182 citations

Response-dependent versus response-independent presentation of cocaine: differences in the lethal effects of the drug

1995 • 182 citations

Physiological and morphological properties of accumbens core and shell neurons recorded in vitro

1993 • 167 citations

Association Basolateral amygdala stimulation evokes glutamate receptor‐dependent dopamine efflux in the nucleus accumbens of the anaesthetized rat

1998 • 164 citations

Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure

2001 • 160 citations

Differential Contributions of the Basolateral and Central Amygdala in the Acquisition and Expression of Conditioned Relapse to Cocaine-Seeking Behavior

2001 • 157 citations

Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration

1996 • 151 citations

The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801

2001 • 150 citations

Context-specific Enhancement of Glutamate Transmission by Cocaine

2000 • 149 citations

Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine.

1994 • 143 citations

Neuroadaptations in Ionotropic and Metabotropic Glutamate Receptor mRNA Produced by Cocaine Treatment

1999 • 132 citations

Functional heterogeneity of the rat medial prefrontal cortex: effects of discrete subarea‐specific lesions on drug‐induced conditioned place preference and behavioural sensitization

1999 • 131 citations

The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humans

2001 • 125 citations

The Ability of Environmental Context to Facilitate Psychomotor Sensitization to Amphetamine Can Be Dissociated from Its Effect on Acute Drug Responsiveness and on Conditioned Responding

2001 • 122 citations

Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine

1991 • 119 citations

The course of neural projection from the prefrontal cortex to the nucleus accumbens in the rat

1996 • 112 citations

Distinct actions of endogenous excitatory amino acids on the outflow of dopamine in the nucleus accumbens.

1993 • 110 citations

Evidence for alcohol anti-craving properties of memantine

1996 • 107 citations

Cocaine-induced conditioned locomotion: Absence of associated increases in dopamine release

1992 • 92 citations

Cocaine conditioning and cocaine sensitization: what is the relationship?

1998 • 92 citations

ΔFosB: a molecular switch underlying long-term neural plasticity

2000 • 87 citations

Amphetamine-Induced Plasticity of AMPA Receptors in the Ventral Tegmental Area: Effects on Extracellular Levels of Dopamine and Glutamate in Freely Moving Rats

2001 • 86 citations

Effects of electrical stimulation of brain reward sites on release of dopamine in rat: An in vivo electrochemical study

1988 • 83 citations

Context-specific cross-sensitization between systemic cocaine and intra-accumbens AMPA infusion in the rat

1996 • 80 citations

Evidence that dopaminergic axons provide a dense innervation of specific neuronal subpopulations in the rat basolateral amygdala

1999 • 79 citations

Sensitization to Cocaine's Reinforcing Effects Produced by Various Cocaine Pretreatment Regimens in Rats

2000 • 67 citations

The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine.

1990 • 67 citations

Repeated Administration of Amphetamine or Cocaine Does Not Alter AMPA Receptor Subunit Expression in the Rat Midbrain,

2002 • 63 citations

Involvement of the Nucleus Accumbens and Medial Prefrontal Cortex in the Expression of Conditioned Hyperactivity to a Cocaine-Associated Environment in Rats

2000 • 60 citations

MK-801 reinstates drug-seeking behaviour in cocaine-trained rats

1998 • 48 citations

Behavioral arousal and increased dopamine efflux after blockade of NMDA-receptors in the prefrontal cortex are dependent on activation of glutamatergic neurotransmission

2002 • 45 citations

Repeated d -amphetamine enhances stimulated mesoamygdaloid dopamine transmission

1997 • 45 citations

Conditioned locomotor-activating and reinforcing effects of discrete stimuli paired with intraperitoneal cocaine

1997 • 36 citations

The glutamate hypothesis of reinforcement learning

2000 • 34 citations

Amphetamine administration does not alter protein levels of the GLT-1 and EAAC1 glutamate transporter subtypes in rat midbrain, nucleus accumbens, striatum, or prefrontal cortex

2001 • 23 citations

Context-specific cross-sensitization between systemic cocaine and intra-accumbens AMPA infusion in the rat

1996 • 16 citations

Neural substrates mediating context-dependent sensitization to psychostimulants

1999 • 4 citations