Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration

1990 • 574 citations

Animal models of drug craving

1993 • 560 citations

Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis

1997 • 525 citations

Opposite Modulation of Cocaine-Seeking Behavior by D ₁ - and D ₂ -Like Dopamine Receptor Agonists

1996 • 493 citations

Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period

1996 • 405 citations

Cocaine-induced cocaine craving

1989 • 381 citations

The First Drink

1974 • 378 citations

Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal

1995 • 364 citations

Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine

1995 • 293 citations

Drug reinstatement of heroin-reinforced responding in the rat

1983 • 266 citations

Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.

1995 • 263 citations

Cocaine-but not food-seeking behavior is reinstated by stress after extinction

1997 • 254 citations

Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects

1990 • 251 citations

Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area

1984 • 219 citations

Reinstatement of Drug-Taking Behavior as a Method of Assessing Incentive Motivational Properties of Drugs

1987 • 182 citations

Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

1990 • 179 citations

Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine.

1996 • 162 citations

Sensitization occurs to the locomotor effects of morphine and the specific μ opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens

1987 • 152 citations

Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen

1997 • 138 citations

Behavioral and neurochemical sensitization following cocaine self-administration

1994 • 133 citations

Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization

1997 • 129 citations

Nicotine reinstatement of nicotine self-administration after long-term extinction

1996 • 118 citations

A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior

1988 • 114 citations

A primate model of polydrug abuse: cocaine and heroin combinations.

1995 • 92 citations

Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its δ- and κ-opioid receptor regulation

1994 • 85 citations

Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats

1991 • 80 citations

Behavioral sensitization is induced by intravenous self-administration of cocaine by rats

1996 • 67 citations

Reinstatement of heroin-reinforced behavior following long-term extinction

1994 • 54 citations

Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.

1990 • 53 citations

Chronic oral cocaine self-administration: pharmacokinetics and effects on spontaneous and discriminative motor functions.

1991 • 52 citations

The role of fentanyl training dose and of the alternative stimulus condition in drug generalization

1982 • 32 citations

Conditioning Phenomena and the Problem of Relapse in Opioid Addicts and Alcoholics

1988 • 11 citations