NMDA receptor antagonists as analgesics: focus on the NR2B subtype

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Genetic enhancement of learning and memory in mice

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Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

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Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Glutamate in CNS disorders as a target for drug development: an update

1998 • 423 citations

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

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Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

2001 • 324 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

Psychotogenicity and N-methyl-D-aspartate receptor antagonism: Implications for neuroprotective pharmacotherapy

1997 • 220 citations

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

1998 • 218 citations

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

1995 • 179 citations

Peripheral excitatory amino acids

2001 • 172 citations

In Vitro Binding Properties in Rat Brain of [³H]Ro 25‐6981, a Potent and Selective Antagonist of NMDA Receptors Containing NR2B Subunits

1998 • 169 citations

A Regulatory Domain (R1–R2) in the Amino Terminus of theN-Methyl-d-Aspartate Receptor: Effects of Spermine, Protons, and Ifenprodil, and Structural Similarity to Bacterial Leucine/Isoleucine/Valine Binding Protein

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Comparison of ketamine and pethidine in experimental and postoperative pain

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Antagonists selective for NMDA receptors containing the NR2B subunit.

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A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task

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Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord

2000 • 137 citations

Antagonists Selective for NMDA Receptors Containing the NR2B Subunit

1999 • 136 citations

Antinociceptive activity of CP‐101,606, an NMDA receptor NR2B subunit antagonist

1997 • 128 citations

Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice

1999 • 111 citations

A Double‐Blind, Placebo‐Controlled Study of the Safety, Tolerability and Pharmacokinetics of CP‐101,606 in Patients with a Mild or Moderate Traumatic Brain Injury

1999 • 102 citations

Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy

1996 • 102 citations

The self-administration of MK-801 can depend upon drug-reinforcement history, and its discriminative stimulus properties are phencyclidine-like in rhesus monkeys.

1990 • 88 citations

Localization of N-methyl-d-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats

2000 • 82 citations

An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones

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Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-d-aspartate receptors?

1988 • 78 citations

The clinically tested N-methyl-d-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy

1995 • 78 citations

Involvement of Spinal NMDA Receptors in Capsaicin-Induced Nociception

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Molecular evidence for the involvement of NR2B subunit containing N-methyl-d-aspartate receptors in the development of morphine-induced place preference

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Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice

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Modulation of [3H]MK-801 binding to NMDA receptors in vivo and in vitro

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Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine, in mice

1996 • 55 citations

Pharmacological effects of the non-competitive NMDA antagonist CNS 1102 in normal volunteers.

1994 • 54 citations

Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil

2001 • 49 citations

Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit

2001 • 41 citations

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

1996 • 41 citations

Lack of amnestic, psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist

1994 • 39 citations

Prepulse inhibition of the startle reflex in rats

1999 • 38 citations

Neuroprotective NMDA Antagonists: the Controversy over Their Potential for Adverse Effects on Cortical Neuronal Morphology

1994 • 36 citations

Stimulus intensity, cell excitation and the N-methyl-d-aspartate receptor component of sensory responses in the rat spinal cord in vivo

1997 • 36 citations

Potent Analgesia Induced in Rats by Combined Action at PCP and Polyamine Recognition Sites of the NMDA Receptor Complex

1993 • 26 citations

Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats

1994 • 25 citations

Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil

2000 • 23 citations

Different capability ofn-methyl-d-aspartate antagonists to elicit EEG and behavioural phencyclidine-like effects in rats

1992 • 22 citations

ChemInform Abstract: (1S,2S)‐1‐(4‐Hydroxyphenyl)‐2‐(4‐hydroxy‐4‐phenylpiperidino)‐1‐ propanol: A Potent New Neuroprotectant Which Blocks N‐Methyl‐D‐ aspartate Responses.

1995 • 21 citations

Qualit?? de vie de patients souffrant d??AOMI trait??s par le tartrate d??ifenprodil

1998 • 14 citations