ΔFosB: a molecular switch underlying long-term neural plasticity

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

AP-1 function and regulation

1997 • 2,833 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments

1996 • 742 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments

1994 • 549 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens

1998 • 382 citations

Striatal fosB Expression Is Causally Linked with l-DOPA-Induced Abnormal Involuntary Movements and the Associated Upregulation of Striatal Prodynorphin mRNA in a Rat Model of Parkinson's Disease

1999 • 344 citations

Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

1997 • 344 citations

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.

1994 • 304 citations

Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments.

1997 • 304 citations

Fos B mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects

1997 • 283 citations

Network-Level Changes in Expression of Inducible Fos–Jun Proteins in the Striatum during Chronic Cocaine Treatment and Withdrawal

1996 • 274 citations

Chronic Fos-Related Antigens: Stable Variants of ΔFosB Induced in Brain by Chronic Treatments

1997 • 273 citations

Immediate-early genes: ten years on

1995 • 209 citations

Transformation by ras modifies AP1 composition and activity

1997 • 207 citations

Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.

1996 • 206 citations

Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.

1995 • 202 citations

Characterization of Enhanced Behavioral Responses tol-DOPA Following Repeated Administration in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

1998 • 189 citations

Chronic Alterations in Dopaminergic Neurotransmission Produce a Persistent Elevation of ΔFosB‐like Protein(s) in both the Rodent and Primate Striatum

1996 • 180 citations

The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

1999 • 179 citations

Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics

1994 • 169 citations

The effects of antipsychotic drugs on fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization

1996 • 147 citations

Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins.

1991 • 145 citations

Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.

1995 • 139 citations

Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-DOPA treatment

1999 • 132 citations

Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment

1994 • 124 citations

D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum

1996 • 114 citations

Implications of prolonged expression of Fos-related antigens

1995 • 106 citations

Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum

1996 • 103 citations

Expression pattern of the AP-1 family in breast cancer: Association of fosB expression with a well-differentiated, receptor-positive tumor phenotype

1999 • 97 citations

Region-specific induction of ?FosB by repeated administration of typical versus atypical antipsychotic drugs

1999 • 92 citations

Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex

1999 • 90 citations

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins

1999 • 82 citations

Neuronal and behavioural abnormalities in striatal function in DARPP‐32‐mutant mice

1999 • 81 citations

Extracellular Signal-regulated Kinase 1/2-mediated Phosphorylation of JunD and FosB Is Required for Okadaic Acid-induced Activator Protein 1 Activation

1999 • 65 citations

Absence of a Persistently Elevated 37 kDa Fos-Related Antigen and AP-1-Like DNA-Binding Activity in the Brains of Kainic Acid-TreatedfosB Null Mice

1997 • 55 citations

Repeated Alcohol Administration Differentially Affects c‐Fos and FosB Protein Immunoreactivity in DBA/2J Mice

1998 • 55 citations

Contrasting Effects of Chronic Clozapine, Seroquel^TM (ICI 204,636) and Haloperidol Administration on ΔFosB‐like Immunoreactivity in the Rodent Forebrain

1996 • 42 citations

Differential effect on U937 cell differentiation by targeting transcriptional factors implicated in tissue- or stage-specific induced integrin expression

1999 • 41 citations

Selective Effects of Alcohol Drinking on Restraint‐Induced Expression of Immediate Early Genes in Mouse Brain

1999 • 39 citations

Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment

1999 • 35 citations

Differential regulation of IL-6 promoter activity in a human ovarian-tumor cell line transfected with variousp53 mutants: Involvement of AP-1

1999 • 32 citations

Coordinate regulation of Fos and Jun proteins in mouse brain by LiCl

1999 • 29 citations

D1-receptor-related priming is attenuated by antisense-meditated `knockdown' of fosB expression

1998 • 28 citations

Ischemia-induced CA1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI-A and JunB levels

1998 • 27 citations

A Short Conserved Motif Is Required for Repressor Domain Function in the Myeloid-specific Transcription Factor CCAAT/Enhancer-binding Protein ε

1999 • 27 citations

Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints

1999 • 22 citations

Engagement of Natural Cytotoxicity Programs Regulates AP-1 Expression in the NKL Human NK Cell Line

1999 • 22 citations

Enterocyte-like differentiation of the Caco-2 intestinal cell line is associated with increases in AP-1 protein binding

1998 • 20 citations

Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines.

2000 • 20 citations

Inhibition of p38 MAP kinase increases okadaic acid mediated AP-1 expression and DNA binding but has no effect on TRE dependent transcription

1999 • 19 citations

A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4–CD8– to CD4+CD8+ thymocytes

1999 • 15 citations

MK-801-induced expression of Fos protein family members in the rat retrosplenial granular cortex

1999 • 7 citations