Src, N-methyl-d-aspartate (NMDA) receptors, and synaptic plasticity

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Protein modules and signalling networks

1995 • 2,447 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

A thousand and one protein kinases

1987 • 1,066 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

1987 • 934 citations

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1993 • 893 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Contrasting properties of two forms of long-term potentiation in the hippocampus

1995 • 839 citations

The role of divalent cations in the N‐methyl‐D‐aspartate responses of mouse central neurones in culture.

1988 • 810 citations

SH2 and SH3 domains

1993 • 697 citations

Regulation of NMDA receptors by tyrosine kinases and phosphatases

1994 • 671 citations

NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

1997 • 614 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Competitive binding of α-actinin and calmodulin to the NMDA receptor

1997 • 591 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit

1996 • 532 citations

CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

1991 • 522 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Calcium-induced actin depolymerization reduces NMDA channel activity

1993 • 510 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

Selective modulation of NMDA responses by reduction and oxidation

1989 • 459 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

1991 • 448 citations

Molecular Neurobiology of Glutamate Receptors

1992 • 436 citations

SAP102, a Novel Postsynaptic Protein That Interacts with NMDA Receptor Complexes In Vivo

1996 • 422 citations

Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain

1993 • 415 citations

Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

1995 • 411 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

1994 • 371 citations

Recognition and specificity in protein tyrosine kinase-mediated signalling

1995 • 367 citations

Src Activation in the Induction of Long-Term Potentiation in CA1 Hippocampal Neurons

1998 • 329 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

NMDA-receptor channel diversity in the developing cerebellum

1994 • 325 citations

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.

1994 • 314 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Subtype‐specific regulation of recombinant NMDA receptor‐channels by protein tyrosine kinases of the src family.

1996 • 309 citations

Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.

1992 • 309 citations

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1990 • 302 citations

Src family protein tyrosine kinases and cellular signal transduction pathways

1995 • 298 citations

Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop

1995 • 293 citations

Neural Tissues Express High Levels of the Cellular src Gene Product pp60^c-src

1983 • 288 citations

Differential Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptor Subunits

1995 • 283 citations

β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase

1996 • 280 citations

Association of Src Tyrosine Kinase with a Human Potassium Channel Mediated by SH3 Domain

1996 • 266 citations

Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity

1993 • 260 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

1995 • 249 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

NMDA Receptor and the Tyrosine Phosphorylation of Its 2B Subunit in Taste Learning in the Rat Insular Cortex

1997 • 235 citations

Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation.

1996 • 230 citations

Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture.

1989 • 225 citations

Modulation of GABAA receptors by tyrosine phosphorylation

1995 • 224 citations

Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A

1994 • 210 citations

Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.

1992 • 209 citations

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

1993 • 208 citations

Structure‐function relationships in Src family and related protein tyrosine kinases

1995 • 201 citations

Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

1997 • 190 citations

Neural tissues express high levels of the cellular src gene product pp60c-src.

1983 • 179 citations

Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo.

1996 • 177 citations

NMDA Receptor Subunits ϵ1 (NR2A) and ϵ2 (NR2B) Are Substrates for Fyn in the Postsynaptic Density Fraction Isolated from the Rat Brain

1995 • 159 citations

Mechanisms of Activation of Glutamate Receptors and the Time Course of Excitatory Synaptic Currents

1995 • 157 citations

Learning Mechanisms: The Case for CaM-KII

1997 • 147 citations

Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.

1990 • 142 citations

Differential Regulation of Proline-rich Tyrosine Kinase 2/Cell Adhesion Kinase β (PYK2/CAKβ) and pp125FAK by Glutamate and Depolarization in Rat Hippocampus

1996 • 135 citations

Protein Tyrosine Kinase‐Mediated Potentiation of Currents from Cloned NMDA Receptors

1996 • 125 citations

The Unique Domain as the Site on Lyn Kinase for Its Constitutive Association with the High Affinity Receptor for IgE

1997 • 124 citations

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

1994 • 115 citations

Functional consequences of NR2 subunit composition in single recombinant N -methyl- <scp>d</scp> -aspartate receptors

1997 • 114 citations

Tyrosine Phosphorylation Modulates Current Amplitude and Kinetics of a Neuronal Voltage-Gated Potassium Channel

1997 • 104 citations

Tyrosine Kinase Is Required for Long-Term Depression in the Cerebellum

1996 • 96 citations

Functional Interaction of Src Family Kinases with the Acetylcholine Receptor in C2 Myotubes

1996 • 94 citations

Modulation of GABA_AReceptor Function by Tyrosine Phosphorylation of β Subunits

1997 • 92 citations

Protein-tyrosine Kinases Activate while Protein-tyrosine Phosphatases Inhibit L-type Calcium Channel Activity in Pituitary GH3 Cells

1996 • 90 citations

A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.

1994 • 90 citations

Identification of a Novel Neuronal C-SRC Exon Expressed in Human Brain

1990 • 88 citations

Immunocytochemical localization of the neuron-specific form of the c- src gene product, pp60c-src(+), in rat brain

1990 • 76 citations

Brain-specific src oncogene mRNA mapped in rat brain by in situ hybridization.

1988 • 66 citations

Identification of a novel neuronal C-SRC exon expressed in human brain.

1990 • 57 citations

Depolarization and Neurotransmitters Increase Neuronal Protein Tyrosine Phosphorylation

1994 • 54 citations

Postnatal Age and Protein Tyrosine Phosphorylation at Synapses in the Developing Rat Brain

1991 • 45 citations

Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites.

1994 • 45 citations

Binding of src-like Kinases to the β-Subunit of the Interleukin-3 Receptor

1997 • 44 citations

Proto-oncogenes and signaling processes in neural tissues

1993 • 41 citations

Tyrosine kinase inhibitors, herbimycin A and lavendustin A, block formation of long-term potentiation in the dentate gyrus in vivo

1993 • 38 citations

Lck Unique Domain Influences Lck Specificity and Biological Function

1995 • 32 citations

Neuronal pp60c-src(+) in the developing chick spinal cord as revealed with anti-hexapeptide antibody

1993 • 8 citations