Domains, motions and regulation in the myosin head

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Mechanism of adenosine triphosphate hydrolysis by actomyosin

1971 • 1,289 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

On the attribution and additivity of binding energies

1981 • 902 citations

Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

1986 • 812 citations

Studies on the chymotryptic digestion of myosin. Effects of divalent cations on proteolytic susceptibility

1977 • 632 citations

Continuous and discontinuous protein antigenic determinants

1986 • 582 citations

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

1986 • 538 citations

Myosin Structure and Function in Cell Motility

1987 • 479 citations

Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle

1965 • 471 citations

Muscle Contraction and Free Energy Transduction in Biological Systems

1985 • 446 citations

The Mechanism of Muscle Contractio

1986 • 424 citations

Bending patterns of Chlamydomonas flagella: IV. Mutants with defects in inner and outer dynein arms indicate differences in dynein arm function

1987 • 396 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Structure of the actin–myosin interface

1981 • 349 citations

Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.

1985 • 340 citations

Sliding movement of single actin filaments on one-headed myosin filaments

1987 • 297 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

The Relation of Muscle Biochemistry to Muscle Physiology

1980 • 286 citations

Structural domains in proteins and their role in the dynamics of protein function

1983 • 283 citations

Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene

1986 • 270 citations

Crossbridge behaviour during muscle contraction

1985 • 249 citations

Orientation of spin labels attached to cross-bridges in contracting muscle fibres

1982 • 248 citations

Mapping of actin-binding sites on the heavy chain of myosin subfragment 1

1983 • 248 citations

Structural relationships of actin, myosin, and tropomyosin revealed by cryo-electron microscopy.

1987 • 248 citations

Structural and Functional Aspects of Domain Motions in Proteins

1984 • 246 citations

Mechanism of the actomyosin adenosine triphosphatase. Evidence that adenosine 5'-triphosphate hydrolysis can occur without dissociation of the actomyosin complex

1979 • 243 citations

Time-resolved X-ray diffraction studies of the myosin layer-line reflections during muscle contraction

1982 • 230 citations

2.5 Å structure of aspartate carbamoyltransferase complexed with the bisubstrate analog N-(phosphonacetyl)-l-aspartate

1987 • 210 citations

Protein Folding

1981 • 206 citations

The enzymic properties of N-ethylmaleimide modified myosin

1964 • 199 citations

The Structures and Related Functions of Phosphorylase a

1980 • 197 citations

Relation between structure and function of α/β–protejns

1980 • 194 citations

Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism

1978 • 188 citations

Location of SH-1 and SH-2 in the heavy chain segment of heavy meromyosin

1978 • 186 citations

Monoclonal antibodies localize changes on myosin heavy chain isozymes during avian myogenesis

1983 • 177 citations

Evaluation of Intrinsic Binding Energy from a Hydrogen Bonding Group in an Enzyme Inhibitor

1987 • 174 citations

The Utilization of Binding Energy in Coupled Vectorial Processes

1980 • 166 citations

Proteolytic approach to structure and function of actin recognition site in myosin heads

1981 • 164 citations

Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum.

1986 • 153 citations

A new model for the geometry of the binding of myosin crossbridges to muscle thin filaments

1981 • 152 citations

Structures of Two Thermolysin-Inhibitor Complexes That Differ by a Single Hydrogen Bond

1987 • 144 citations

Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1.

1979 • 139 citations

Phosphorylation of Smooth Muscle Myosin: Evidence for Cooperativity Between the Myosin Heads

1981 • 136 citations

Electron microscopy of scallop myosin

1983 • 132 citations

Basic biology of muscles: A comparative approach

1983 • 129 citations

Three-dimensional reconstruction of thin filaments decorated with a Ca2+-regulated myosin

1982 • 127 citations

Fluorescence resonance energy transfer measurements of distances in actin and myosin. A critical evaluation

1987 • 120 citations

Regulatory properties of single-headed fragments of scallop myosin

1979 • 115 citations

Angles of nucleotides bound to cross-bridges in glycerinated muscle fiber at various concentrations of ϵ-ATP, ϵ-ADP and ϵ-AMPPNP detected by polarized fluorescence

1981 • 110 citations

Negative staining of myosin molecules

1985 • 108 citations

Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens.

1987 • 104 citations

Molecular movements promoted by metal nucleotides in the heavy-chain regions of myosin heads from skeletal muscle

1985 • 102 citations

Probing myosin head structure with monoclonal antibodies

1986 • 101 citations

Identification of an active site peptide of skeletal myosin after photoaffinity labeling with N-(4-azido-2-nitrophenyl)-2-aminoethyl diphosphate.

1985 • 99 citations

Proton Nuclear‐Magnetic‐Resonance Spectroscopy of Myosin Subfragment 1 Isoenzymes

1981 • 98 citations

Pressure-relaxation studies of pyrene-labelled actin and myosin subfragment 1 from rabbit skeletal muscle. Evidence for two states of acto-subfragment 1

1985 • 95 citations

Spectroscopic Probes of Muscle Cross-Bridge Rotation

1987 • 94 citations

Movement of myosin fragments in vitro: Domains involved in force production

1987 • 89 citations

Structural evidence that myosin heads may interact with two sites on F-actin

1982 • 88 citations

ATP-linked monomer-polymer equilibrium of smooth muscle myosin: the free folded monomer traps ADP.Pi.

1986 • 87 citations

Fibrous protein structure

1988 • 87 citations

On the mechanism of energy transduction in myosin subfragment 1.

1984 • 82 citations

Structure of the actin-myosin complex in the presence of ATP.

1985 • 81 citations

Photochemical probes of the active site of myosin. Irradiation of trapped 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate labels the 50-kilodalton heavy chain tryptic peptide.

1984 • 78 citations

Electron microscopic visualization of the SH1 thiol of myosin by the use of an avidin-biotin system

1984 • 74 citations

Light-chain movement and regulation in scallop myosin

1983 • 73 citations

Packing analysis of crystalline myosin subfragment-1

1985 • 73 citations

A conformational transition in gizzard heavy meromyosin involving the head-tail junction, resulting in changes in sedimentation coefficient, ATPase activity, and orientation of heads.

1985 • 72 citations

Antibodies directed against N-terminal residues on actin do not block acto-myosin binding

1987 • 69 citations

Cross-bridges and the mechanism of muscle contraction

1983 • 68 citations

Location of the ATPase site of myosin determined by three-dimensional electron microscopy

1987 • 68 citations

Foerster energy transfer measurements of thiol 1 to thiol 2 distances in myosin subfragment 1

1983 • 67 citations

A new myosin fragment: visualization of the regulatory domain

1984 • 63 citations

Mapping myosin light chains by immunoelectron microscopy. Use of anti-fluorescyl antibodies as structural probes.

1989 • 61 citations

Evidence for cross-bridge order in contraction of glycerinated skeletal muscle.

1983 • 61 citations

Calcium regulation of molluscan myosin ATPase in the absence of actin

1985 • 59 citations

Tryptic digestion of scallop S1: evidence for a complex between the two light-chains and a heavy-chain peptide

1984 • 57 citations

Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents.

1980 • 57 citations

Localisation of light chain and actin binding sites on myosin

1986 • 55 citations

Angle of active site of myosin heads in contracting muscle during sudden length changes

1985 • 55 citations

Three-Dimensional Image Analysis of the Complex of Thin Filaments and Myosin Molecules from Skeletal Muscle. IV.1 Reconstitution from Minimal- and High-Dose Images of the Actin-Tropomyosin-Myosin Subfragment-1 Complex2

1985 • 53 citations

Interaction of Myosin Subfragment-1 with Actin

1979 • 53 citations

Isolation and partial renaturation of proteolytic fragments of the myosin head.

1984 • 50 citations

Myosin subunit interactions. Localization of the alkali light chains.

1985 • 48 citations

Amino acid sequence of myosin essential light chain from the scallop Aquipecten irradians

1986 • 45 citations

New states of actomyosin.

1987 • 45 citations

The essential light chains constitute part of the active site of smooth muscle myosin

1986 • 43 citations

Substructure of Myosin Subfragment-1 as Revealed by Digestion with Proteolytic Enzymes

1980 • 41 citations

Myosin subfragment 1 has tertiary structural domains

1986 • 39 citations

Abolition of ATPase activities of skeletal myosin subfragment 1 by a new selective proteolytic cleavage within the 50-kilodalton heavy chain segment

1986 • 38 citations

Antigenic probes locate the myosin subfragment 1 interaction site on the N-terminal part of actin

1986 • 38 citations

Stabilization of a primary loop in myosin subfragment 1 with a fluorescent crosslinker.

1985 • 36 citations

Actin-binding peptide obtained by the cyanogen bromide cleavage of the 20-kDa fragment of myosin subfragment-1.

1985 • 36 citations

Proximity of regulatory light chains in scallop myosin

1985 • 35 citations

Nucleotide trapping at the ATPase site of myosin subfragment 1 by a new interthiol crosslinking.

1986 • 34 citations

Both the 25-kDa and 50-kDa domains in myosin subfragment 1 are close to the reactive thiols.

1986 • 34 citations

Electron microscopic visualization of the ATPase site of myosin by photoaffinity labeling with a biotinylated photoreactive ADP analog.

1986 • 33 citations

Fluorescence studies on the nucleotide- and Ca2+-binding domains of molluscan myosin

1985 • 32 citations

Identification of polyphosphate recognition sites communicating with the actin sites on the skeletal myosin subfragment-1 heavy chain

1986 • 31 citations

8-Anilino-1-naphthalenesulphonate, a fluorescent probe for the regulatory light chain binding site of scallop myosin

1984 • 31 citations

Properties of the alkali light-chain-20-kilodalton fragment complex from skeletal myosin heads

1986 • 30 citations

Fluorescence energy transfer studies on the proximity of the two essential thiols of myosin subfragment-1.

1983 • 29 citations

The purification and characterization of a globular subfragment of Acanthamoeba myosin II that is fully active when cross-linked to F-actin.

1986 • 27 citations

Resonance energy transfer evidence for two attached states of the actomyosin complex

1985 • 26 citations

Substructure of skeletal myosin subfragment 1 revealed by thermal denaturation

1987 • 24 citations

Domain structure of the myosin head in correlation-averaged images of shadowed molecules

1988 • 22 citations

Proximity and ligand-induced movement of interdomain residues in myosin subfragment 1 containing trapped MgADP and MgPPi probed by multifunctional cross-linking.

1987 • 21 citations

Amino Acid Sequence of the 203-Residue Fragment of the Heavy Chain of Chicken Gizzard Myosin Containing the SH Cysteine Residue12

1986 • 21 citations

Electron microscopy of cross-linked scallop myosin

1985 • 21 citations

The actin‐activated ATPase of regulated and unregulated scallop heavy meromyosin

1986 • 18 citations

A new, smaller actin-activatable myosin subfragment 1 which lacks the 20-kDa, SH1 and SH2 peptide.

1987 • 17 citations

Light chain dependent effects of actin binding on the swivel in myosin

1985 • 16 citations

Structural changes induced in scallop heavy meromyosin molecules by Ca2+ and ATP

1992 • 15 citations

Structural Models for the Regulatory Switch of Myosin

1986 • 15 citations

Spatial relationship between SH₁ and the actin binding site on myosin subfragment‐1 surface

1984 • 11 citations

Selective cleavage of skeletal myosin subfragment‐1 to form a 26 kDa peptide which shows ATP‐sensitive actin binding

1989 • 10 citations

Role of the myosin light chains in the regulation of contractile activity.

1982 • 10 citations

Myosin binding to actin

1987 • 9 citations

An intact heavy chain at the actin-subfragment 1 interface is required for ATPase activity of scallop myosin

1987 • 9 citations

Recognition of DNA sequences by the repressor of bacteriophage 434

1988 • 8 citations

Crosslinking of the skeletal myosin subfragments 1 heavy chain to the amino terminal region of actin within residues 40 113

1987 • 5 citations

Mechanism and control of scallop myosin atpase

1987 • 1 citations

Deleted Work

1955 • 0 citations