Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL

2003 • 624 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Imatinib as a Paradigm of Targeted Therapies

2004 • 366 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

Imatinib (STI571)-Mediated Changes in Glucose Metabolism in Human Leukemia BCR-ABL-Positive Cells

2004 • 248 citations

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia

1999 • 243 citations

Gleevec (STI571) Influences Metabolic Enzyme Activities and Glucose Carbon Flow toward Nucleic Acid and Fatty Acid Synthesis in Myeloid Tumor Cells

2001 • 187 citations

Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression

1998 • 124 citations

Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML

2002 • 119 citations

BCR – ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

1998 • 116 citations

Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line.

1994 • 112 citations

Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression

1998 • 96 citations

Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells

2001 • 92 citations

Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL

2001 • 76 citations

Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface

2003 • 76 citations

Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors

1992 • 58 citations

Biology of BCR-ABL

1999 • 51 citations

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

2002 • 50 citations

Glucose transport regulation by p210 Bcr–Abl in a chronic myeloid leukaemia model

2001 • 44 citations

p210 Bcr–Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia

1998 • 40 citations

Role of Phosphatidylinositol 3-Kinase and Specific Protein Kinase B Isoforms in the Suppression of Apoptosis Mediated by the Abelson Protein-tyrosine Kinase

2000 • 39 citations

Bcl-xL and Akt cooperate to promote leukemogenesis in vivo

2003 • 34 citations

The Hemopoietic Growth Factor, Interleukin-3, Promotes Glucose Transport by Increasing the Specific Activity and Maintaining the Affinity for Glucose of Plasma Membrane Glucose Transporters

1997 • 31 citations

Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line

1993 • 29 citations

IL-3 facilitates lymphocyte hexose transport by enhancing the intrinsic activity of the transport system

1991 • 26 citations

Phosphatidylinositol‐3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells

2004 • 24 citations

Evidence that cell survival is controlled by interleukin‐3 independently of cell proliferation

1995 • 21 citations

Hemopoietic cell transformation is associated with failure to downregulate glucose uptake during the G2/M phase of the cell cycle

2003 • 5 citations

Apoptosis in Hematopoiesis and Leukemogenesis

1996 • 3 citations