Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Barrier Function of the Skin: “La Raison d'Être” of the Epidermis

2003 • 1,076 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

2001 • 787 citations

Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice

2004 • 564 citations

Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

1976 • 552 citations

The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1

2000 • 446 citations

Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes

1989 • 373 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.

1988 • 359 citations

The regulation of stearoyl-CoA desaturase (SCD)

1995 • 333 citations

Membrane Structures in Normal and Essential Fatty Acid-Deficient Stratum Corneum: Characterization by Ruthenium Tetroxide Staining and X-Ray Diffraction

1991 • 296 citations

Role of stearoyl-coenzyme A desaturase in lipid metabolism

2003 • 287 citations

A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis

2001 • 274 citations

Lipids and barrier function of the skin

2000 • 266 citations

Targeted Disruption of Stearoyl-CoA Desaturase1 Gene in Mice Causes Atrophy of Sebaceous and Meibomian Glands and Depletion of Wax Esters in the Eyelid

2001 • 249 citations

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

1999 • 231 citations

Identification and Characterization of Murine SCD4, a Novel Heart-specific Stearoyl-CoA Desaturase Isoform Regulated by Leptin and Dietary Factors

2003 • 201 citations

Peroxisome-Proliferator-Activated Receptor (PPAR)-γ Activation Stimulates Keratinocyte Differentiation

2004 • 188 citations

Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and α-linolenate

1985 • 188 citations

Scd3—A Novel Gene of the Stearoyl-CoA Desaturase Family with Restricted Expression in Skin

2001 • 188 citations

Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

2000 • 187 citations

Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle

2003 • 182 citations

The Extracellular Calcium-sensing Receptor Is Required for Calcium-induced Differentiation in Human Keratinocytes

2001 • 146 citations

Sphingolipid Activator Proteins Are Required for Epidermal Permeability Barrier Formation

1999 • 143 citations

Oleoyl-CoA Is the Major de NovoProduct of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2,3-diacylglycerol

2001 • 110 citations

Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip

2003 • 77 citations

Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs

1987 • 77 citations

Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Δ6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse

2002 • 67 citations

Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

2003 • 56 citations

Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

2003 • 53 citations

Metabolism of linoleic acid in porcine epidermis

1990 • 49 citations

The Effect of LXR Activators on AP-1 Proteins in Keratinocytes

2004 • 41 citations

Biosynthesis of Acylceramide in Murine Epidermis: Characterization by Inhibition of Glucosylation and Deglucosylation, and by Substrate Specificity

2004 • 26 citations