Role of protein kinase B in insulin-regulated glucose uptake

Regulated transport of the glucose transporter GLUT4

2002 • 1,154 citations

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

2003 • 937 citations

Structure, regulation and function of PKB/AKT—a major therapeutic target

2003 • 695 citations

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

2001 • 606 citations

A Method to Identify Serine Kinase Substrates

2002 • 516 citations

Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes

2004 • 447 citations

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

2003 • 356 citations

The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

2002 • 354 citations

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

1997 • 301 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Insulin Stimulation of GLUT4 Exocytosis, but Not Its Inhibition of Endocytosis, Is Dependent on RabGAP AS160

2004 • 220 citations

GLUT4 Retention in Adipocytes Requires Two Intracellular Insulin-regulated Transport Steps

2002 • 177 citations

Insulin Signaling in Microdomains of the Plasma Membrane

2003 • 171 citations

Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake

2000 • 142 citations

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

2004 • 141 citations

Akt-2 Binds to Glut4-containing Vesicles and Phosphorylates Their Component Proteins in Response to Insulin

1999 • 128 citations

Protein Kinase B Stimulates the Translocation of GLUT4 but Not GLUT1 or Transferrin Receptors in 3T3-L1 Adipocytes by a Pathway Involving SNAP-23, Synaptobrevin-2, and/or Cellubrevin

1999 • 122 citations

RNAi-based Analysis of CAP, Cbl, and CrkII Function in the Regulation of GLUT4 by Insulin

2004 • 113 citations

c-Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

2004 • 108 citations

Insulin Accelerates Inter-endosomal GLUT4 Traffic via Phosphatidylinositol 3-Kinase and Protein Kinase B

2001 • 98 citations

Involvement of the Akt/PKB signaling pathway with disease processes.

2003 • 95 citations

Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

2003 • 93 citations

Analysis of insulin signalling by RNAi-based gene silencing

2004 • 89 citations

GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualized with green-fluorescent protein

1997 • 79 citations

PIKfyve: The road to PtdIns 5‐P and PtdIns 3,5‐P₂

2001 • 78 citations

Requirement for PIKfyve Enzymatic Activity in Acute and Long-Term Insulin Cellular Effects

2002 • 77 citations

Primary and Essential Role of the Adaptor Protein APS for Recruitment of Both c-Cbl and Its Associated Protein CAP in Insulin Signaling

2004 • 69 citations

Novel insulin-elicited phosphoproteins in adipocytes

2004 • 41 citations

Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles

2002 • 41 citations