Tumor Necrosis Factor-α Regulates Expression of Vascular Endothelial Growth Factor Receptor-2 and of Its Co-receptor Neuropilin-1 in Human Vascular Endothelial Cells

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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

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1992 • 1,345 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

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1987 • 1,210 citations

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

1997 • 1,131 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

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Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

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Cytokine regulation of endothelial cell function

1992 • 684 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

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Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

1994 • 571 citations

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1996 • 570 citations

Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.

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1994 • 464 citations

Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells

1996 • 459 citations

The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

1996 • 382 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

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1996 • 351 citations

Intracellular Pool of Vascular Endothelial Growth Factor in Human Neutrophils

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1991 • 320 citations

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1996 • 298 citations

The molecular action of tumor necrosis factor-alpha

1991 • 279 citations

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

1993 • 263 citations

Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha.

1988 • 221 citations

In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.

1992 • 187 citations

Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells

1990 • 182 citations

Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.

1991 • 174 citations

Cloning and Functional Analysis of the Promoter for KDR/flk-1, a Receptor for Vascular Endothelial Growth Factor

1995 • 173 citations

Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

1996 • 170 citations

Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells

1996 • 164 citations

A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein

1990 • 159 citations

Characterization of the Promoter for the Human Long Pentraxin PTX3

1997 • 154 citations

Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.

1994 • 149 citations

Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

1994 • 144 citations

Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothelial cells.

1991 • 139 citations

Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects

1991 • 128 citations

Expression of tumour necrosis factor (TNFα) and its receptors in benign and malignant breast tissue

1994 • 126 citations

Molecular cloning and characterization of mutant and wild-type human beta-actin genes.

1984 • 108 citations

Platelet-activating factor directly stimulates in vitro migration of endothelial cells and promotes in vivo angiogenesis by a heparin-dependent mechanism.

1995 • 108 citations

Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells.

1992 • 90 citations

Endogenous basic fibroblast growth factor-dependent induction of collagenase and interleukin-6 in tumor necrosis factor-treated human microvascular endothelial cells.

1991 • 80 citations

Role of tumor necrosis factor‐α and platelet‐activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis

1996 • 67 citations

Nuclear Protein Interactions with the Human KDR/flk-1 Promoter in Vivo

1997 • 55 citations

Detection of tumor necrosis factor-α protein and messenger RNA in human glial brain tumors: comparison of immunohistochemistry with in situ hybridization using molecular probes

1995 • 39 citations

Deleted Work

1955 • 0 citations