The role of IFN-γ in immune responses to viral infections of the central nervous system

Immunobiology: the immune system in health and disease

1995 • 3,893 citations

Antiviral Actions of Interferons

2001 • 2,683 citations

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

IRF Family of Transcription Factors as Regulators of Host Defense

2001 • 1,566 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Noncytolytic Control of Viral Infections by the Innate and Adaptive ImmuneResponse

2001 • 1,000 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

MALARIAL DIABETES

1948 • 829 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein

1999 • 741 citations

Defective Viral Particles and Viral Disease Processes

1970 • 683 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

1997 • 600 citations

When Two Strands Are Better Than One: The Mediators and Modulators of the Cellular Responses to Double-Stranded RNA

1996 • 574 citations

Nitric oxide and the regulation of gene expression

2001 • 529 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

2000 • 491 citations

Herpes Simplex Encephalitis

1986 • 464 citations

Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm

1987 • 464 citations

Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase

1996 • 436 citations

7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure

1993 • 426 citations

Measles Encephalomyelitis — Clinical and Immunologic Studies

1984 • 404 citations

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

2001 • 397 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression

2001 • 347 citations

Biologic consequences of Stat1-independent IFN signaling

2001 • 345 citations

Endothelial Cells as Mediators of Vasodilation of Arteries

1984 • 322 citations

Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions

2001 • 318 citations

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

2000 • 314 citations

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle

1992 • 291 citations

Nitric oxide :principles and actions

1996 • 280 citations

Does Nitric Oxide Play a Critical Role in Viral Infections?

1998 • 273 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

Nitric oxide inhibits viral replication in murine myocarditis.

1996 • 249 citations

Interferon-γ-Mediated Site-Specific Clearance of Alphavirus from CNS Neurons

2001 • 248 citations

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus.

1983 • 247 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

Gamma Interferon Can Prevent Herpes Simplex Virus Type 1 Reactivation from Latency in Sensory Neurons

2001 • 243 citations

Vesicular stomatitis virus infects and matures only through the basolateral surface of the polarized epithelial cell line, MDCK

1984 • 236 citations

Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1

1995 • 231 citations

ANTIBODIES TO HERPESVIRUS HOMINIS TYPES 1 AND 2 IN HUMANS1

1970 • 223 citations

The Human 2',5'-Oligoadenylate Synthetase Family: Interferon-Induced Proteins with Unique Enzymatic Properties

1999 • 223 citations

Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.

1994 • 211 citations

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways

2000 • 203 citations

Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after local cerebral ischemia in rat

1994 • 200 citations

Cloning and expression of inducible nitric oxide synthase from rat astrocytes

1994 • 200 citations

Production of nitrite by neonatal rat microglial cells/ brain macrophages

1992 • 198 citations

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

1995 • 193 citations

Antiviral activity of the pregnancy recognition hormone ovine trophoblast protein-1

1988 • 191 citations

The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus

2000 • 188 citations

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

1995 • 179 citations

Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism

2000 • 176 citations

Viral infections in interferon-γ receptor deficiency

1999 • 173 citations

Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication

1995 • 164 citations

Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance

1998 • 164 citations

The glycoprotein G of rhabdoviruses

1995 • 160 citations

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product

1985 • 159 citations

Immune-Mediated Protection from Measles Virus-Induced Central Nervous System Disease Is Noncytolytic and Gamma Interferon Dependent

2002 • 152 citations

Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity

1995 • 150 citations

ERK1 and ERK2 Activate CCAAAT/Enhancer-binding Protein-β-dependent Gene Transcription in Response to Interferon-γ

2001 • 146 citations

Regulation of the IL‐12/IL‐12R axis: a critical step in T‐helper cell differentiation and effector function

1999 • 146 citations

Biochemical and Genetic Evidence for Complex Formation Between the Influenza A Virus NS1 Protein and the Interferon-induced PKR Protein Kinase

1998 • 142 citations

Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells

1994 • 139 citations

The Effects of Human Immunodeficiency Virus in the Central Nervous System

1998 • 134 citations

Interferon-γ induced type I nitric oxide synthase activity inhibits viral replication in neurons

1996 • 133 citations

MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line

1993 • 133 citations

Enhanced virus resistance of transgenic mice expressing the human MxA protein

1995 • 130 citations

Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

1997 • 128 citations

Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation

1999 • 128 citations

The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo

1996 • 124 citations

RNase L Mediates the Antiviral Effect of Interferon through a Selective Reduction in Viral RNA during Encephalomyocarditis Virus Infection

1998 • 120 citations

Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism.

1994 • 120 citations

Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein

1991 • 119 citations

The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation

1998 • 118 citations

The Earliest Events in Vesicular Stomatitis Virus Infection of the Murine Olfactory Neuroepithelium and Entry of the Central Nervous System

1995 • 117 citations

Alpha and Gamma Interferons Inhibit Herpes Simplex Virus Type 1 Infection and Spread in Epidermal Cells after Axonal Transmission

2001 • 116 citations

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

1995 • 115 citations

Nuclear Localization of the Interferon-Inducible Protein Kinase PKR in Human Cells and Transfected Mouse Cells

1995 • 112 citations

Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice

1993 • 111 citations

Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites.

1995 • 108 citations

Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry.

1972 • 106 citations

The predominance of CD8+ T cells after infection with measles virus suggests a role for CD8+ class I MHC-restricted cytotoxic T lymphocytes (CTL) in recovery from measles. Clonal analyses of human CD8+ class I MHC-restricted CTL.

1990 • 105 citations

Interferon-γ Protects against Herpes Simplex Virus Type 1-Mediated Neuronal Death

1997 • 104 citations

Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice

1999 • 104 citations

Oligonucleotide fingerprints of RNA species obtained from rhabdoviruses belonging to the vesicular stomatitis virus subgroup

1977 • 102 citations

INFLUENCE OF HOST FACTORS ON NEUROINVASIVENESS OF VESICULAR STOMATITIS VIRUS

1937 • 96 citations

Sex differences in susceptibility to viral infection of the central nervous system

1996 • 95 citations

Effects of PKR/RNase L-Dependent and Alternative Antiviral Pathways on Alphavirus Replication and Pathogenesis

2002 • 94 citations

FURTHER EPIDEMIOLOGICAL STUDIES OF SUBACUTE SCLEROSING PANENCEPHALITIS

1973 • 93 citations

Nitric oxide inhibition of coxsackievirus replication in vitro.

1997 • 92 citations

S‐Nitrosylation of Viral Proteins: Molecular Bases for Antiviral Effect of Nitric Oxide

1999 • 91 citations

Activation of Type III Nitric Oxide Synthase in Astrocytes Following a Neurotropic Viral Infection

1996 • 91 citations

Distribution of vesicular stomatitis virus proteins in the brain of BALB/c mice following intranasal inoculation: an immunohistochemical analysis

1994 • 90 citations

Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses

1993 • 89 citations

Measles virus-specific human T cell clones. Characterization of specificity and function of CD4+ helper/cytotoxic and CD8+ cytotoxic T cell clones.

1989 • 87 citations

Conceptus Interferons and Maternal Recognition of Pregnancy1

1989 • 86 citations

Neuronal interferon‐γ immunoreactive molecule: Bioactivities and purification

1994 • 84 citations

Nitric Oxide Facilitates Long-Term Potentiation, But Not Long-Term Depression

1997 • 83 citations

SELECTIVE INFECTIONS OF OLFACTORY AND RESPIRATORY EPITHELIUM BY VESICULAR STOMATITIS AND SENDAI VIRUSES

1987 • 83 citations

Transgenic mice expressing IFN-gamma in the retina develop inflammation of the eye and photoreceptor loss.

1994 • 83 citations

Interferon‐gamma‐like immunoreactivity in certain neurons of the central and peripheral nervous system

1989 • 83 citations

IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system.

1995 • 82 citations

Thymic Aplasia With Lymphopenia, Plasma Cells, and Normal Immunoglobulins

1967 • 82 citations

Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection

1997 • 81 citations

Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice

1998 • 77 citations

Interferons Inhibit Onset of Murine Cytomegalovirus Immediate-Early Gene Transcription

1993 • 77 citations

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination

1995 • 76 citations

IL-12 and Viral Infections

1998 • 75 citations

HIV-I-associated central nervous system dysfunction

2000 • 74 citations

Apoptosis induction in brain during the fixed strain of rabies virus infection correlates with onset and severity of illness

1998 • 74 citations

Novel Cell Type–Specific Antiviral Mechanism of Interferon γ Action in Macrophages

2001 • 74 citations

Expression of nitric oxide synthase in human peripheral blood mononuclear cells and neutrophils.

1995 • 73 citations

Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways

2000 • 73 citations

An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

2001 • 72 citations

Interferonγ Activation of Raf-1 Is Jak1-dependent and p21ras-independent

1998 • 72 citations

Inducible Expression of the 2-5A Synthetase/RNase L System Results in Inhibition of Vaccinia Virus Replication

1997 • 71 citations

Susceptibility to measles virus-induced encephalitis in mice correlates with impaired antigen presentation to cytotoxic T lymphocytes

1993 • 68 citations

CCAAT/Enhancer-binding Protein-β Regulates Interferon-induced Transcription through a Novel Element

2000 • 67 citations

Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system

1991 • 67 citations

Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon‐γ‐induced MAPK activation that is mediated by p21^ras

1997 • 66 citations

Regulation of Human Immunodeficiency Virus Replication by 2′,5′-Oligoadenylate-Dependent RNase L

1998 • 65 citations

Effect of Deficiency of the Double-Stranded RNA-Dependent Protein Kinase, PKR, on Antiviral Resistance in the Presence or Absence of Ribonuclease L: HSV-1 Replication Is Particularly Sensitive to Deficiency of the Major IFN-Mediated Enzymes

2000 • 64 citations

Assembly and transcription of synthetic vesicular stomatitis virus nucleocapsids

1991 • 63 citations

The antiviral role of nitric oxide

1995 • 63 citations

Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system

2001 • 63 citations

Host Immune Response to Vesicular Stomatitis Virus Infection of the Central Nervous System in C57BL/6 Mice

1996 • 62 citations

Interferon γ-induced transcription of the murine ISGF3γ (p48) gene is mediated by novel factors

1997 • 60 citations

Viruses and Multiple Sclerosis

2000 • 59 citations

Cysteine Nitrosylation Inactivates the HIV-1 Protease

1998 • 59 citations

Rhabdovirus Biology and Infection

1987 • 57 citations

Neuronal Expression of NOS-1 Is Required for Host Recovery from Viral Encephalitis

1999 • 56 citations

PKR Protection Against Intranasal Vesicular Stomatitis Virus Infection Is Mouse Strain Dependent

2002 • 52 citations

Interferon-γ-responsive neuronal sites in the normal rat brain: receptor protein distribution and cell activation revealed by Fos induction

2000 • 51 citations

Nitric oxide as a chemical link in the generation of pain from veins in humans

1996 • 50 citations

Expression of interferon-gamma receptors on murine oligodendrocytes and its regulation by cytokines and mitogens.

1995 • 50 citations

Establishment of Latent Herpes Simplex Virus Type 1 Infection in Resistant, Sensitive, and Immunodeficient Mouse Strains

2000 • 49 citations

Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ

2000 • 48 citations

Glial Cells of the Spinal Cord and Subcortical White Matter Up-regulate Neuronal Nitric Oxide Synthase in Sporadic Amyotrophic Lateral Sclerosis

2001 • 46 citations

Cytokine-mediated survival from lethal herpes simplex virus infection: role of programmed neuronal death.

1995 • 46 citations

Prefrontal cortex dysfunction in borna disease virus (BDV)-infected rats

1996 • 45 citations

CD4+ T cells are essential in overcoming experimental murine measles encephalitis.

1994 • 45 citations

Mx proteins: antiviral proteins by chance or by necessity?

1990 • 45 citations

Nitric Oxide Inhibits the HIV-1 Reverse Transcriptase Activity

1999 • 41 citations

Regulated Expression of the Interferon-Induced Protein Kinase p68 (PKR) by Vaccinia Virus Recombinants Inhibits the Replication of Vesicular Stomatitis Virus but Not That of Poliovirus

1996 • 40 citations

Role of interferon-γ in the pathogenesis of LCMV-induced meningitis: unimpaired leucocyte recruitment, but deficient macrophage activation in interferon-γ knock-out mice

1998 • 39 citations

Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry

1972 • 38 citations

Pathogenic aspects of measles virus infections

1999 • 38 citations

IFN-gamma is not required in the IL-12 response to vesicular stomatitis virus infection of the olfactory bulb.

1997 • 37 citations

Ectopic expression of gamma interferon in the eye protects transgenic mice from intraocular herpes simplex virus type 1 infections

1994 • 37 citations

Interleukin-12 Promotes Recovery from Viral Encephalitis

1997 • 37 citations

Gamma interferon-like immunoreactive material in rat neurons: Evidence against a close relationship to gamma interferon

1991 • 36 citations

Measles virus interactions with cellular receptors: Consequences for viral pathogenesis

2001 • 34 citations

Cytolytic T lymphocytes from the BALB/c-H-2dm2 mouse recognize the vesicular stomatitis virus glycoprotein and are restricted by class II MHC antigens.

1990 • 33 citations

Demonstration of the presence of a specific interferon-γ receptor on murine astrocyte cell surface

1991 • 31 citations

Human interferon omega--a review.

1995 • 31 citations

HIV-1-related central nervous system diseases

1999 • 30 citations

Viruses and autoimmunity: an affair but not a marriage contract

2002 • 29 citations

The house that JAK/STAT built

1997 • 28 citations

Gases as neurotransmitters

1998 • 28 citations

A role for interferons in early pregnancy

1991 • 26 citations

Detection of vesicular stomatitis virus RNA and its defective-interfering particles in individual mouse brains

1984 • 26 citations

Mechanisms of Cytokine-Mediated Inhibition of Viral Replication

1999 • 24 citations

Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases

2001 • 22 citations

Innate Immune Responses in Viral Encephalitis

2002 • 21 citations

Herpes Simplex Virus Type 1 Glycoprotein B Requires a Cysteine Residue at Position 633 for Folding, Processing, and Incorporation into Mature Infectious Virus Particles

1998 • 21 citations

Thymic aplasia with lymphopenia, plasma cells, and normal immunoglobulins. Relation to measles virus infection

1967 • 18 citations

Radiation inactivation analysis of fusion and hemolysis by vesicular stomatitis virus

1988 • 18 citations

Neuronal IFN-γ in tuberomammillary neurones

1994 • 17 citations

Mx gene control of interferon action: different kinetics of the antiviral state against influenza virus and vesicular stomatitis virus

1983 • 16 citations

Cortical cholinergic decline parallels the progression of Borna virus encephalitis

2001 • 16 citations

Replication-defective viruses modulate immune responses.

1991 • 12 citations

The Intracellular Reactions of Nitric Oxide in the Immune System and Its Enzymatic Synthesis

1996 • 12 citations

Interferon-induced proteins and their mechanisms of action.

1994 • 9 citations

Antiproliferative effects of NO synthase products

1991 • 8 citations

Protective and Pathological Immune Responses in the CNS

2002 • 8 citations

Therapeutic challenges of neonatal herpes simplex virus infection.

1985 • 6 citations

Lymphokine Expression Profile of Resting and Stimulated CD4+ CTL Clones Specific for the Glycoprotein of Vesicular Stomatitis Virus

1993 • 5 citations

Interferons and maternal recognition of pregnancy.

1989 • 4 citations

Pathophysiology of cerebral ischemia and trauma in relation to possible therapeutic approaches.

1990 • 3 citations

Deleted Work

1955 • 0 citations