Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

1993 • 470 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells

1982 • 386 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 207 citations

REGULATION OF VACCINIA VIRUS TRANSCRIPTION

1990 • 194 citations

Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration.

1980 • 186 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Importance of interferons in recovery from mousepox

1993 • 146 citations

Nuclear Localization of a Double-Stranded RNA-Binding Protein Encoded by the Vaccinia Virus E3L Gene

1993 • 128 citations

Assembly of vaccinia virus: effects of rifampin on the intracellular distribution of viral protein p65

1994 • 124 citations

Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system

1984 • 113 citations

The Antiviral Effects of the Interferons and Their Inhibition

1992 • 69 citations

Targeting of a multicomponent transcription apparatus into assembling vaccinia virus particles requires RAP94, an RNA polymerase-associated protein

1994 • 61 citations

The Enzymology of Poxvirus DNA Replication

1990 • 52 citations

Interferon-γ Severely Inhibits DNA Synthesis of Vaccinia Virus in a Macrophage Cell Line

1994 • 46 citations

Lymphocyte–Macrophage Interactions and Macrophage Activation in the Expression of Antimicrobial Immunity in Vivo

1976 • 45 citations

Mechanism of interferon action: Human leukocyte and immune interferons regulate the expression of different genes and induce different antiviral states in human amnion U cells

1983 • 44 citations

Structure and expression of the vaccinia virus gene which prevents virus-induced breakdown of RNA

1990 • 38 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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