IL-12 and Viral Infections

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Cytokine receptor signalling

1995 • 1,242 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

1993 • 496 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Does Nitric Oxide Play a Critical Role in Viral Infections?

1998 • 273 citations

Interleukin-12 inhibits hepatitis B virus replication in transgenic mice

1997 • 237 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system

1993 • 218 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo.

1996 • 214 citations

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.

1992 • 209 citations

Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function.

1991 • 195 citations

Interleukin 12: A key modulator of immune function

1994 • 190 citations

Role of Interleukin-12 in Primary Influenza Virus Infection

1998 • 184 citations

TNF-α transgenic and knockout models of CNS inflammation and degeneration

1997 • 164 citations

Cloning and characterization of a mouse IL-12 receptor-beta component.

1995 • 155 citations

Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity

1995 • 150 citations

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin‐12) on cell‐mediated cytotoxicity against tumor‐derived and virus‐infected cells

1993 • 150 citations

Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer.

1997 • 150 citations

Mice Lacking IL-12 Develop Polarized Th1 Cells During Viral Infection

1998 • 149 citations

Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.

1997 • 147 citations

Interferon-γ induced type I nitric oxide synthase activity inhibits viral replication in neurons

1996 • 133 citations

Interleukin-12 gene expression after viral infection in the mouse

1995 • 119 citations

Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection.

1996 • 118 citations

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.

1997 • 112 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

Cytokines and the CNS

2005 • 109 citations

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

1994 • 106 citations

Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus

1997 • 105 citations

Regulation of interleukin‐12 receptor β1 chain expression and interleukin‐12 binding by human peripheral blood mononuclear cells

1997 • 102 citations

Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.

1997 • 92 citations

Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endothelium

1994 • 92 citations

Activation of Type III Nitric Oxide Synthase in Astrocytes Following a Neurotropic Viral Infection

1996 • 91 citations

Interleukin-18: Perspectives on the Newest Interleukin

1998 • 83 citations

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM

1991 • 83 citations

IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system.

1995 • 82 citations

Regulation of brain-derived T cells during acute central nervous system inflammation.

1997 • 74 citations

The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.

1997 • 69 citations

IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice.

1995 • 65 citations

Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection

1996 • 63 citations

Host Immune Response to Vesicular Stomatitis Virus Infection of the Central Nervous System in C57BL/6 Mice

1996 • 62 citations

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

1995 • 59 citations

Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12.

1996 • 57 citations

Astrocytes and Microglia Produce Interleukin-12 p40

1996 • 56 citations

Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections

1997 • 44 citations

Neuroprotection in CNS diseases

1997 • 39 citations

In Vivo Regulation of the IL-1β System (Ligand, Receptors I and II, Receptor Accessory Protein, and Receptor Antagonist) and TNF-α mRNAs in Specific Brain Regions

1996 • 38 citations

IFN-gamma is not required in the IL-12 response to vesicular stomatitis virus infection of the olfactory bulb.

1997 • 37 citations

Interleukin-12 Promotes Recovery from Viral Encephalitis

1997 • 37 citations

Herpesvirus saimiri immortalized gamma delta T cell line activated by IL-12.

1996 • 31 citations

Suicide by order: Some open questions about the cell-killing activities of the TNF ligand and receptor families

1996 • 30 citations

The house that JAK/STAT built

1997 • 28 citations

Structure of the Mouse IL‐12R01 Chain and Regulation of Its Expression in BCG/LPS‐Treated Mice

1996 • 12 citations