Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

Antibody neutralization and escape by HIV-1

2003 • 2,384 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

HIV preferentially infects HIV-specific CD4+ T cells

2002 • 1,246 citations

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

2003 • 1,192 citations

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

2002 • 1,180 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Immune control of HIV-1 after early treatment of acute infection

2000 • 1,012 citations

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 • 999 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

2000 • 901 citations

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

2002 • 894 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 • 693 citations

Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load

2003 • 674 citations

Poxviruses and Immune Evasion

2003 • 639 citations

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

2003 • 563 citations

A role for carbohydrates in immune evasion in AIDS

1998 • 562 citations

Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody

1992 • 481 citations

An Effective AIDS Vaccine Based on Live Attenuated Vesicular Stomatitis Virus Recombinants

2001 • 441 citations

Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.

1998 • 431 citations

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy

2003 • 380 citations

Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus

1998 • 334 citations

Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

1999 • 312 citations

Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo

2002 • 289 citations

Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen

2000 • 259 citations

Kinetics of the immune response during HBV and HCV infection

2003 • 252 citations

Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

2001 • 240 citations

Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

1998 • 227 citations

CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects

2001 • 217 citations

Immune Responses During Measles Virus Infection

1995 • 165 citations

Vaccination of Seronegative Volunteers with a Human Immunodeficiency Virus Type 1env/revDNA Vaccine Induces Antigen‐Specific Proliferation and Lymphocyte Production of β‐Chemokines

2000 • 157 citations

Dynamics of T Cell Responses in HIV Infection

2002 • 145 citations

Effect of Humoral Immune Responses on Controlling Viremia during Primary Infection of Rhesus Monkeys with Simian Immunodeficiency Virus

2003 • 144 citations

Dissecting the host response to a γ–herpesvirus

2001 • 129 citations

Defining the Protective Antibody Response for HIV-1

2003 • 120 citations

Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Cytolytic T Lymphocyte Responses in Seronegative Adults by a Nonreplicating, Host-Range-Restricted Canarypox Vector (ALVAC) Carrying the HIV-1MN env Gene

1995 • 102 citations

A Novel Recombinant Adeno-Associated Virus Vaccine Induces a Long-Term Humoral Immune Response to Human Immunodeficiency Virus

2001 • 100 citations

Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines

2003 • 94 citations

AIDS Vaccine Trial Produces Disappointment and Confusion

2003 • 92 citations

IMMUNE RESPONSES TO VARICELLA-ZOSTER VIRUS

1996 • 89 citations

A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques

2002 • 79 citations

Immunogenicity of a Recombinant Human Immunodeficiency Virus (HIV)–Canarypox Vaccine in HIV‐Seronegative Ugandan Volunteers: Results of the HIV Network for Prevention Trials 007 Vaccine Study

2003 • 70 citations

The Evolution of Antigen-Specific CD8⁺T Cell Responses after Natural Primary Infection of Humans with Epstein-Barr Virus

2003 • 57 citations

Humoral immune response to human papillomavirus infection

1997 • 48 citations

Tissue xenografts as a model system for study of the pathogenesis of papillomaviruses

1997 • 44 citations

Vaccine-elicited immune responses prevent clinical AIDS in SHIV89.6P-infected rhesus monkeys

2001 • 35 citations