A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

2000 • 901 citations

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1997 • 696 citations

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

1998 • 663 citations

Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection

1996 • 578 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

1999 • 384 citations

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1995 • 383 citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

1997 • 345 citations

Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus

1998 • 334 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

1999 • 312 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry

1998 • 285 citations

Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen

2000 • 259 citations

Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

1998 • 227 citations

Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus

1998 • 220 citations

Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression

1998 • 219 citations

Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya.

2000 • 199 citations

Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques

1995 • 188 citations

Immune responses in HIV-exposed seronegatives: have they repelled the virus?

1995 • 181 citations

Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.

1991 • 171 citations

Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection

2000 • 162 citations

Lack of infection in HIV-exposed individuals is associated with a strong CD8⁺cell noncytotoxic anti-HIV response

1999 • 153 citations

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

1998 • 140 citations

Immunization with a Single Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Recognition Epitope of Herpes Simplex Virus Type 2 Confers Protective Immunity

1998 • 120 citations

Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo.

1996 • 114 citations

Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime

1999 • 106 citations

Dose Dependence of CTL Precursor Frequency Induced by a DNA Vaccine and Correlation with Protective Immunity Against Influenza Virus Challenge

1999 • 87 citations

Antigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes

1998 • 83 citations

Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: the Ariel Project for the Prevention of Transmission of HIV from Mother to Infant

1999 • 78 citations

Characterization of HIV-1-specific T-helper cells in acute and chronic infection

1999 • 74 citations

Human Immunodeficiency Virus Type 1 (HIV‐1)‐Specific T Cell Responses Correlate with Control of Acute HIV‐1 Infection in Macaques

1997 • 45 citations

Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals

1996 • 32 citations

Prospect of a prophylactic vaccine for HIV

2001 • 12 citations