Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Drug excretion mediated by a new prototype of polyspecific transporter

1994 • 637 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1995 • 419 citations

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1995 • 385 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1996 • 275 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

1996 • 194 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver.

1996 • 152 citations

Multispecific amphipathic substrate transport by an organic anion transporter of human liver

1996 • 140 citations

[11] Isolated perfused rat liver technique

1981 • 128 citations

Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations

1990 • 95 citations

Transport of small organic cations in the rat liver

1996 • 91 citations

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

1994 • 82 citations

Continuous Intravenous Infusion of Rocuronium (ORG 9426) in Patients Receiving Balanced, Enflurane, or Isoflurane Anesthesia

1993 • 80 citations

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver

1992 • 70 citations

Effect of Cyclosporine on Colchicine Secretion by A Liver Canalicular Transporter Studied In Vivo

1992 • 65 citations

Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters

1997 • 64 citations

ATP‐dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P‐glycoprotein

1994 • 56 citations

Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers.

1993 • 55 citations

Effect of the nonimmunosuppressive cyclosporin analog SDZ PSC-833 on colchicine and doxorubicin biliary secretion by the rat in vivo

1994 • 47 citations

Hepatic extraction, metabolism and biliary excretion of doxorubicin in the isolated prefused rat liver

1987 • 47 citations

Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethylammonium

1992 • 44 citations

Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in rat liver

1993 • 44 citations

HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients

1991 • 43 citations

A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver

1992 • 41 citations

Assay of vecuronium in plasma using solid-phase extraction, high-performance liquid chromatography and post-column ion-pair extraction with fluorimetric detection

1987 • 40 citations

Hepatic uptake and biliary excretion of organic cations—I

1984 • 39 citations

Mechanisms for the uptake of cationic drugs by the liver: a study with tributylmethylammonium (TBuMA).

1991 • 35 citations

Hepatic uptake and biliary excretion of d-tubocurarine and trimethyltubocurarine in the rat in vivo and in isolated perfused rat livers.

1976 • 35 citations

The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein.

1994 • 34 citations

Sequestration of organic cations by acidified hepatic endocytic vesicles and implications for biliary excretion.

1992 • 32 citations

Inhibition of rhodamine 123 secretion by cyclosporin A as a model of P-glycoprotein mediated transport in liver.

1994 • 31 citations

Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepatocytes: contribution of type I system.

1994 • 31 citations

Transport of N1-methylnicotinamide by organic cation-proton exchange in rat liver membrane vesicles

1990 • 30 citations

Mechanisms for the hepatic uptake and biliary excretion of tributylmethylammonium: studies with rat liver plasma membrane vesicles.

1996 • 23 citations

Organic cation transport by rat liver lysosomes

1995 • 22 citations

Thiamine transport by basolateral rat liver plasma membrane vesicles

1992 • 21 citations

Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport

1994 • 19 citations

The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium

1971 • 19 citations

Measurement of plasma membrane potential in isolated rat hepatocytes using the lipophilic cation, tetraphenylphosphonium: Correction of probe intracellular binding and mitochondrial accumulation

1992 • 18 citations

Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.

1992 • 16 citations

Transport and accumulation of lipophilic dye cations at the mitochondria of HeLa cells in situ.

1993 • 13 citations

Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB 8-5 cells

1996 • 11 citations

Organic cation transport by rat hepatocyte basolateral membrane vesicles

1992 • 11 citations

Deleted Work

1955 • 0 citations